Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial

Ayşan, Erhan; İdiz, Ufuk Oğuz; Elmas, Leyla; Sağlam, Esra; Akgün, Züleyha; Yücel, Serap

doi:10.1080/08941939.2016.1232449

Cited by 29 publications

(24 citation statements)

References 39 publications

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“…Previous reports showed that radiation-induced skin reactions were observed in ~90% of breast cancer patients undergoing adjuvant postoperative radiotherapy. 21 , 22 In our data, the incidence is lower than the previous reports. It needs to be studied further if the skin color affects it.…”

Section: Discussioncontrasting

confidence: 75%

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The incidence of postoperative radiotherapy-induced acute dermatitis in breast cancer and its influencing factors for Chinese women

Ding

Guo

et al. 2018

OTT

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PurposeTo investigate the incidence of skin acute reaction and its influencing factors in postoperative breast cancer radiotherapy patients.MethodsOne hundred and seventy three cases of breast cancer patients treated with postoperative radiotherapy were consecutively enrolled from June 1, 2016 to July 31, 2017 in our breast cancer center. Irradiation technology includes conformal intensity-modulated radiotherapy and a conventional two-dimensional one with conventional fraction. Any acute radiation dermatitis was recorded and the influencing factors were analyzed at the end of the radiation treatment.ResultsRadiotherapy-induced acute dermatitis in patients with breast-conserving surgery was relatively mild. Among the 173 patients, 33 cases had no obvious changes in the skin (grade 0); 121 cases had grade 1 skin reactions, manifested as local dark erythema and dry peeling; 29 cases had grade 2 skin reactions, characterized by edema, hyperemia, or erosion part; no grade 3 cases of skin reactions were observed. The incidence of grade 0, grade 1, and grade 2 reactions in all patients was 19.1%, 69.9%, and 11.0%, respectively. The severity of skin acute reaction is independent of the tumor sites, molecular subtypes, patients’ age, and irradiation modalities, but it depends on the surgical types, fields treated, and planned total radiation. There is a trend favoring no chemotherapy over chemotherapy, though p-value is 0.074.ConclusionSkin acute reaction in postoperative radiotherapy breast cancer patients is generally common but mild, and there are quite a few patients who need interruption or cessation of the radiotherapy process. The patients need to be well informed and made aware that any skin reaction will likely be mild, especially for the breast-conserving patients.

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Section: Discussioncontrasting

confidence: 75%

“… 8 There is no clear evidence indicating that a specific product can prevent or treat radiation-induced dermatitis. 9 …”

Section: Introductionmentioning

confidence: 99%

The incidence of postoperative radiotherapy-induced acute dermatitis in breast cancer and its influencing factors for Chinese women

Ding

Guo

et al. 2018

OTT

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“…In in-vitro and in-vivo studies performed by our group, sodium pentaborate has been shown to exert antiinflammatory effects through cell proliferation, cell migration, and growth factor expression pathways and to accelerate wound healing in different wound models [12,13]. In a prospective randomized clinical trial, we also revealed that sodium pentaborate gel prevents radiation induced dermatitis in breast cancer patients [14]. Adhesions cover a maximum of 1/3 of the model area Spontaneously separating adhesion 2…”

Section: Discussionmentioning

confidence: 82%

“…As boron is very similar to the carbon atom, many carbon-based molecules are the same as the boron-based molecules [1]. e wound healing benefits of some types of boron compounds, especially sodium pentaborate, have been previously documented [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation

Ayşan

Şahın

Catal

et al. 2020

Obstetrics and Gynecology International

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Background. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically. Results. Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p<0.001). Conclusion. 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.

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“…Aysan ve ark.nın yaptığı çalışmada, meme kanseri hastalarında, borun radyasyona bağlı cilt reaksiyonlarını azalttığı gözlenmiş ve bu etkinin, borun antioksidan ve yara iyileştirici özelliğinden kaynaklanabileceği düşünülmüştür. 62…”

Section: Meme Kanseri̇unclassified

Boron and Health

Söğüt¹,

Acar²

2020

J Lit Pharm Sci

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Doğada borat ve borik asit formu ile su ve toprakta bulunan borun, yakın zamana kadar zehirleyici etkileri daha yaygın olarak bilinse de 1997 yılından beri beslenme ve klinikte önemli rolü gündeme gelmiştir. 1,2 Kuruyemiş (fındık, ceviz, yer fıstığı, badem), meyve (ananas, vişne, üzüm, avokado, kayısı, şeftali) ve sebzelerde (brokoli, havuç, taze fasulye) bulunur. [2][3][4] Bölgesel açıdan farklılıklar gösterse de genel olarak günlük bor alımı 1-7 mg olarak bildirilmiştir. 5Bor, insan vücuduna beslenme, solunum ve sabun, deterjan, kozmetik yolu ile deriden girer. Deriden geçiş, herhangi bir yara yoksa ihmal edilebilir düzeydedir. Borun %85-90'ı, vücuda alındıktan kısa süre sonra değişmeden idrarla atılır, ancak %10-15'lik kısmı boratlar hâlinde bağırsaklardan emilir ve beyin-omurilik sıvısı, kemik, beyin, karaciğer ve yağ dokularında birikir. 4,5 ÖZET Sağlıklı canlıların metabolizmalarında önemli rolü olan bor, bir mikrobesindir. Borun insan sağlığına olan etkilerini özetlersek; (1) Kemiklerin yapısının korunması, büyümesi ve bakımı için önemlidir; (2) Kalsiyum, magnezyum, fosfor ve D vitamini gibi bazı vücut minerallerinin düzenlenmesinde rol alır; (3) Vücudun östrojen ve testosteron kullanımını etkiler; (4) Anti-inflamatuar etki gösterir ve romatoid artrit ile ilişkilidir; (5) Süperoksid dismutaz, katalaz ve glutatyon peroksidaz gibi antioksidan enzimlerin düzeylerini artırır; (6) Elektriksel beyin aktivitesini, bilişsel performansı ve yaşlılarda kısa-dönem hafızayı geliştirir; (7) Yara iyileştirici ve antimikrobiyal etkileri vardır; (8) Prostat, akciğer, meme kanserleri, beyin tümörleri üzerinde koruyucu ve tedavi edici etkileri olduğu bildirilmiştir. Dünya Sağlık Örgütünce sağlıklı erişkin bir bireyin beslenme ile alabileceği bor miktarı 1-13 mg olarak belirlenmiştir. Çeşitli kuruyemişler, baklagiller, meyve ve sebzeler bor açısından zengindir. Osteoporoz, osteoartrit, meme, prostat, akciğer kanserli veya riski olan, yeterli meyve ve sebze tüketmeyen kişilere bor takviyeli beslenme uygulandığında, bu hastalıklarla ilgili olumlu sonuçlar alındığı bildirilmiştir. Aşırı dozda bor alınması durumunda, erişkinlerde baş ağrısı, kusma, ishal, psikolojik sorunlar; çocuklarda havale ve beyin zarı tahribi yapabileceği rapor edilmiştir. Ancak öldürücü dozu aşmak çok zordur. Bu derleme; borun insan sağlığı üzerindeki belirgin etkilerini ve borun yeni tedavilerde kullanımını kapsayan çalışmaları bir araya getirmeye odaklanmıştır. Anah tar Ke li me ler:Bor; sağlık; fayda; terapötik kullanım ABS TRACT Boron, which plays an important role in the metabolism of healthy living organisms, is a micronutrient. To summarize the effect of boron on human health; (1) Is essential for the protection, growth and maintenance of bone; (2) Plays a role in the regulation of some body minerals such as calcium, magnesium, phosphorus and vitamin D;(3) Impacts the body's use of estrogen, testosterone (4) Has anti-imflammatory effect and related with romatoid arthrit; (5) Raises levels of antioxidant enzymes, such as superoxide dismutase, catalas...

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Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial

Abstract: Using the RTOG scoring system, we revealed that the application of a boron-based gel diminished RISR. The mechanism of action is unclear but may be related to antioxidant, wound healing, and thermal degradation effects of boron.

Cited by 29 publications

References 39 publications

The incidence of postoperative radiotherapy-induced acute dermatitis in breast cancer and its influencing factors for Chinese women

The incidence of postoperative radiotherapy-induced acute dermatitis in breast cancer and its influencing factors for Chinese women

Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation

Boron and Health

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