Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation

Abstract

Background. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically. Results. Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p<0.001). Conclusion. 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.

Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

“…We produced new formulation compounded with 3% glycerol and 3% sodium pentaborate and patented it. We demonstrated that this new formulation reduces PPA more effectively than glycerol by itself 20 .…”

“…The wound healing effects of various boron compounds have previously been demonstrated 17 , 19 . During in-vitro and in-vivo studies performed by our team, sodium pentaborate was shown to exert anti-inflammatory effects through cell proliferation, cell migration, and growth factor expression pathways and to accelerate wound healing in different wound models 17 , 19 , 20 . In a prospective randomized clinical trial, we also showed that sodium pentaborate gel can prevent radiation-induced dermatitis in breast cancer patients 18 .…”

“…We concluded that our results are related to synergistic effect of sodium pentaborate and glycerol. Sodium pentaborate ensures anti-inflammatory and wound healing acceleration features, and glycerol ensures effective mechanical separation of the wound healing environment 20 .…”