Effects of bilayer gelatin/β-tricalcium phosphate sponges loaded with mesenchymal stem cells, chondrocytes, bone morphogenetic protein-2, and platelet rich plasma on osteochondral defects of the talus in horses

Seo, Jong-pil; Tanabe, T; Tsuzuki, Nao; Haneda, Shingo; Yamada, Kazutaka; Furuoka, Hidefumi; Tabata, Yasuhiko; Sasaki, Naoki

doi:10.1016/j.rvsc.2013.08.016

Cited by 41 publications

(42 citation statements)

References 28 publications

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“…Seo et al [68] confirmed that the therapeutic effects of bilayer gelatin/β-TCP (GT) combined with stem cells, chondrocyte, BMP-2, and PRP (Ch/MSC/PRP/GT) on osteochondral defects of the talus in horse stimulated osteochondral regeneration [68].…”

Section: Mixed Injection Of Mscsmentioning

confidence: 96%

“…Platelet-rich plasma (PRP) is an autologous platelet gel that contains hundreds of chondrogenic growth factors including TGF-β and platelet-derived growth factor (PDGF) as well as platelet concentrate that is important to repair injury in osteochondral defect [18,68]. Seo et al [68] confirmed that the therapeutic effects of bilayer gelatin/β-TCP (GT) combined with stem cells, chondrocyte, BMP-2, and PRP (Ch/MSC/PRP/GT) on osteochondral defects of the talus in horse stimulated osteochondral regeneration [68].…”

Section: Mixed Injection Of Mscsmentioning

confidence: 99%

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Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Purwanthi¹,

Marta²,

Adiwardhana³

2017

Recent Advances in Biology and Medicine

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Osteoarthritis (OA) is the most common form of arthritis that affects cartilage joints and leads to disability. OA becomes the major public health problem, as it is the most leading cause of disability and morbidity worldwide. Treatment choices for OA can be classified into several categories such as non-pharmacologic, pharmacologic, surgical therapy, and cell-based therapy. There is no curative treatment for OA, while conventional treatments that are commonly used focus on alleviating the pain as the main symptom of the disease. Mesenchymal stem cells (MSCs) that can be found in several tissues of human body offer a new strategy for OA treatment owing to their ability to differentiate into chondrocytes. This article provides an overview about the basic concept of osteoarthritis as well as an insight about the MSCs therapy, including their basic characteristics, source, and transplantation strategies in the OA area.

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Section: Mixed Injection Of Mscsmentioning

confidence: 96%

Section: Mixed Injection Of Mscsmentioning

confidence: 99%

Osteoarthritis and Mesenchymal Stem Cell Therapy: An Overview

Purwanthi¹,

Marta²,

Adiwardhana³

2017

Recent Advances in Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…The types of scaffolds used in the eligible studies varied from malleable gel-like plugs [57][58][59][60][61][62][63][64] to solid scaffolds [65][66][67] or bone-or cartilage-mimicking inserts [68][69][70][71][72][73][74][75][76] (Tables 1 and 2). One study used a tissue-engineered cartilage construct as the implant, 77 66 The use of cell-seeded scaffolds with PRP provided favorable results because 80% of these studies (8 of 10) showed positive regenerative outcomes (structural and biochemical) when using this strategy for cartilage repair.…”

Section: Scaffoldsmentioning

confidence: 99%

“…One study used a tissue-engineered cartilage construct as the implant, 77 66 The use of cell-seeded scaffolds with PRP provided favorable results because 80% of these studies (8 of 10) showed positive regenerative outcomes (structural and biochemical) when using this strategy for cartilage repair.…”

Section: Scaffoldsmentioning

confidence: 99%

“…Some studies were able to see less prominent sites of integration between the implanted scaffold and native tissue, 58,60,62,65 whereas distinct margins were usually seen in control groups. Histologic analysis was performed in all studies except one 58 and commonly showed significantly improved repair cartilage in the presence of PRP (8 of 12 studies) 57,[59][60][61][65][66][67]70 ( Tables 1 and 4). Histologic samples of the repair cartilage were quantitatively analyzed using the modified O'Driscoll histologic score scale, 80 ICRS histologic scale, 54 or Niederauer histologic score.…”

Section: Animal Studiesmentioning

confidence: 99%

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