Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi

Abath, Frederico G. C.; Gomes, Yara M.; Coutinho, Eridan M.; Montenegro, Sílvia Maria Lucena; Mélo, Maria Eliane Bezerra de; Carvalho, Alexandre B. de

doi:10.1590/s0037-86821986000300006

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…In general, CL in this region may be considered an occupational disease, since most of the infected individuals are members of the agricultural workforce, which means that healthy individuals are put in close contact with the wild cycle of the parasite, creating a high risk of exposure to infected phlebotomine bites. The village has experienced a sharp increase in the number of CL cases since 1983 [ 29 , 30 ], leading to an outbreak in 1986 [ 31 ]. The last epidemiological study revealed an annual incidence of 8.1 cases per 1000 inhabitants and a prevalence of 14.9% [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

et al. 2017

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BackgroundNeglected tropical diseases (NTDs) prevail in conditions of poverty and contribute to the maintenance of social inequality. Out of the NTDs prioritized by the Brazilian Ministry of Health, four parasitic infections require mandatory notification: acute Chagas disease, leishmaniasis, malaria, and schistosomiasis. Data on the behaviour of these NTDs in the young population are currently limited. This study seeks to analyse the epidemiological aspects of these parasitic infections in children and adolescents in Brazil.MethodsA retrospective exploratory ecological study was conducted. A spatial analysis of the cases reported between 2009 and 2013 in individuals aged between 0 and 19 years that were notified through the Health Notification Aggravation Information System (SINAN) was performed.ResultsIn total, 64,567 cases of cutaneous and visceral leishmaniasis, malaria, schistosomiasis, and acute Chagas disease were recorded in the SINAN database, representing a rate of 20.15 cases per 100,000 inhabitants. The average age of the cases was 12.2 years and 62.32% were male. Four hundred and three deaths related to these obligatorily reported parasites were recorded, indicating a case fatality rate of 0.62%. Visceral leishmaniasis and acute Chagas disease had the highest rates of lethality. A heterogeneous spatial distribution of the studied parasites was observed.ConclusionsThe number of cases and the lethality rate described in this study show that these diseases still represent a serious problem for public health in Brazil. This points to the need to encourage new research and the reformulation of social, economic, and public health policies aimed at ensuring better health and living conditions for all individuals, especially those among the populations considered vulnerable, as is the case of the young.Electronic supplementary materialThe online version of this article (10.1186/s40249-017-0369-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

et al. 2017

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Longitudinal study of the indirect immunofluorescence and complement fixation tests for diagnosis of chagas' disease in immunosuppressed patients submitted to renal transplantation

Figueiredo¹,

Fiorillo²,

Ferraz³

1993

Rev. Soc. Bras. Med. Trop.

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Clinical and serological follow-up of 7 patients submitted to renal transplantation and presenting positive serological reactions to Chagas' disease before immunosuppression did not show significant changes in indirect immunofluorescence and complement fixation titres for Chagas' disease, or signs and symptoms indicating exacerbation of the disease during follow-up. In addition, 18 of 66 recipients of renal transplants considered to be non-chagasic before immunosuppression showed at least one positive result to the indirect immunofluorescence test for Chagas' disease during the study period. The results suggest that the immunosuppression state induced in chagasic patients submitted to renal transplant did not promoted exacerbation of the chronic infection in these patients and not interfere with the serological response of chronic chagasics, thus permitting the use of these serologic reactions for diagnostic purposes in these cases. However, the positive results of the indirect immunofluorescence test in non-chagasic patients indicate the need for judicious interpretation of the indirect immunofluorescence test for the diagnosis of Chagas' disease in renal transplanted patients.

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Influência de corticóide, na doença de Chagas crônica, administrado em virtude de afecções associadas

Rassi

Neto

Siqueira

et al. 1997

Rev. Soc. Bras. Med. Trop.

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O comportamento da infecção humana pelo Trypanosoma cruzi quando vigente imunodeficiência ainda requer melhores esclarecimentos. Essa necessidade está ficando cada vez mais imperiosa porque a concomitância de doença de Chagas e afecções nas quais o distúrbio imunitário existe é atualmente mais comum e, também, em virtude do maior u s o a t u a l d e f á r m a c o s q u e o r i g i n a m a imunodepressão 2 9 10 . Além disso, a crescente realização de transplantes de órgãos, sendo preciso coibir rejeições, envolve hoje, em várias oportunidades, pacientes acometidos pela enfermidade referida, figurando eles como doadores ou receptores 6 8 11 . O número de relatos de investigações experimentais, sobre a atuação de corticóide, desenvolvidas nos modelos baseados em diferentes tipos de animais, representados sobretudo por camundongos, é razoável. A despeito de não haver unanimidade, as deduções indicam comumente aumentos da parasitemia, do parasitismo tecidual e da mortalidade, revelando também mudança do tropismo em relação aos órgãos que o T. cruzi infecta e atenuação do contingente inflamatório.Tais estudos focalizaram as fases aguda, pós-aguda imediata e crônica, tendo apontado, além do que já citamos, comportamentos diversos de cepas 1 3 5 12 13. Nessas pesquisas, diferentes modalidades de corticóide foram utilizadas, isoladamente ou em associação com compostos tripanossomicidas.No que concerne a pacientes com doença de Chagas, reativações vêm sendo comprovadas quando recebem coração por meio de transplante, corticóide fazendo parte da tática imunossupressora, ou em virtude da administração de certos fár macos para tratamento de leucemias, acrescentando-se a isso, hoje em dia, a participação da síndrome da imunodeficiência adquirida (AIDS)

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Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi

Cited by 6 publications

References 5 publications

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013

Longitudinal study of the indirect immunofluorescence and complement fixation tests for diagnosis of chagas' disease in immunosuppressed patients submitted to renal transplantation

Influência de corticóide, na doença de Chagas crônica, administrado em virtude de afecções associadas

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