Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Petrosyan, Tigran; Gevorkyan, O. V.; Hovsepyan, A. S.

doi:10.1080/00222895.2013.865588

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…E-mail: ti petrosyan @hsc. wvu.edu activity of melanin was shown both on animals and plants (Popov 2003;Petrosyan et al 2014aPetrosyan et al , 2014b. The objective of the current research is to study the effect of initial training on motor recovery in rats after corticospinal tract lesion and application of BM solution.…”

Section: Introductionmentioning

confidence: 97%

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

Petrosyan

2014

Somatosensory & Motor Research

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Training induces plastic changes within the normal and injured brain. Experiments were performed on 48 albino rats. Part of the experimental animals were initially trained to a balancing instrumental conditioned reflex (ICR). Unilateral bulbar pyramidotomy performed in all rats caused contralateral hemiparesis. To make the study results more reliable, recovery of motor skills was evaluated also in conditions of stimulated regeneration. The obtained results indicate that preoperative training in rats contributes to the accelerated recovery of learned motor skills.

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Section: Introductionmentioning

confidence: 97%

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

Petrosyan

2014

Somatosensory & Motor Research

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The comparison of biological effects of bacterial and synthetic melanins in neuroblastoma cells

Handl

Majtnerová

Čapek

et al. 2022

Food and Chemical Toxicology

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Bacterial melanin promotes recovery after sciatic nerve injury in rats

Gevorkyan¹,

Meliksetyan²,

Petrosyan³

et al. 2015

Neural Regen Res

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Bacterial melanin, obtained from the mutant strain of Bacillus Thuringiensis, has been shown to promote recovery after central nervous system injury. It is hypothesized, in this study, that bacterial melanin can promote structural and functional recovery after peripheral nerve injury. Rats subjected to sciatic nerve transection were intramuscularly administered bacterial melanin. The sciatic nerve transected rats that did not receive intramuscular administration of bacterial melanin served as controls. Behavior tests showed that compared to control rats, the time taken for instrumental conditioned reflex recovery was significantly shorter and the ability to keep the balance on the rotating bar was significantly better in bacterial melanin-treated rats. Histomorphological tests showed that bacterial melanin promoted axon regeneration after sciatic nerve injury. These findings suggest that bacterial melanin exhibits neuroprotective effects on injured sciatic nerve, contributes to limb motor function recovery, and therefore can be used for rehabilitation treatment of peripheral nerve injury.

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Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Cited by 3 publications

References 28 publications

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

The comparison of biological effects of bacterial and synthetic melanins in neuroblastoma cells

Bacterial melanin promotes recovery after sciatic nerve injury in rats

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