Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

Petrosyan, Tigran

doi:10.3109/08990220.2014.940078

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…One such promising therapy is specific behavioral experience (such as motor skill training after experimental brain injury), which provides functional benefits [ 5 , 6 ]. There is emerging evidence of the importance of task-specific training (TST) as a neuromotor intervention in neurological restoration [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery

Choi

Lee

Kim

et al. 2018

IJMS

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To develop new rehabilitation therapies for chronic stroke, this study examined the effectiveness of task-specific training (TST) and TST combined with DNA methyltransferase inhibitor in chronic stroke recovery. Eight weeks after photothrombotic stroke, 5-Aza-2′-deoxycytidine (5-Aza-dC) infusion was done on the contralesional cortex for four weeks, with and without TST. Functional recovery was assessed using the staircase test, the cylinder test, and the modified neurological severity score (mNSS). Axonal plasticity and expression of brain-derived neurotrophic factor (BDNF) were determined in the contralateral motor cortex. TST and TST combined with 5-Aza-dC significantly improved the skilled reaching ability in the staircase test and ameliorated mNSS scores and cylinder test performance. TST and TST with 5-Aza-dC significantly increased the crossing fibers from the contralesional red nucleus, reticular formation in medullar oblongata, and dorsolateral spinal cord. Mature BDNF was significantly upregulated by TST and TST combined with 5-Azd-dC. Functional recovery after chronic stroke may involve axonal plasticity and increased mature BDNF by modulating DNA methylation in the contralesional cortex. Our results suggest that combined therapy to enhance axonal plasticity based on TST and 5-Aza-dC constitutes a promising approach for promoting the recovery of function in the chronic stage of stroke.

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Section: Introductionmentioning

confidence: 99%

Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery

Choi

Lee

Kim

et al. 2018

IJMS

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Rehabilitative Training in Animal Models of Spinal Cord Injury

Torres-Espín

Beaudry

Fenrich³

et al. 2018

Journal of Neurotrauma

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Rehabilitative motor training is currently one of the most widely used approaches to promote moderate recovery following injuries of the central nervous system. Such training is generally applied in the clinical setting, whereas it is not standard in preclinical research. This is a concern as it is becoming increasingly apparent that neuroplasticity enhancing treatments require training or some form of activity as a co-therapy to promote functional recovery. Despite the importance of training and the many open questions regarding its mechanistic consequences, its use in preclinical animal models is rather limited. Here we review approaches, findings and challenges when training is applied in animal models of spinal cord injury, and we suggest recommendations to facilitate the integration of training using an appropriate study design, into pre-clinical studies.

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Transcortical photothrombotic pyramidotomy model with persistent motor deficits

et al. 2018

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Traditional pyramidotomy models have a high mortality rate from breathing difficulties and show early recovery from the induced motor deficits. This study establishes a novel pyramidotomy technique in Sprague Dawley rats that generates persistent motor deficits and has a reduced mortality rate. We used viral neural tracing to identify the course and relative distribution of forelimb and hindlimb motor fibers (n = 9). On basis of the neural tracing data, the medullary pyramid was targeted dorsally from the cerebellar cortex for photothrombotic infarct lesioning (n = 18). The photothrombotic technique selectively destroyed the corticospinal fibers in the medullary pyramid with relative preservation of neighboring grey-matter tissue. MicroPET imaging using 2-deoxy-2-[18F]-fluoro-D-glucose (FDG-microPET) showed a decrease in regional cerebral glucose metabolism (rCGM) in the bilateral pyramid and ipsilateral sensory cortex (p < 0.001, FDR q < 0.05). In addition, the trapezoid bodies and superior olivary nuclei showed a decrease in rCGM, compatible with damage caused during the introduction of the optical fiber. Connected structures such as the inferior colliculi and auditory cortices also showed decreases in rCGM in both hemispheres (p < 0.001, FDR q < 0.05). There was a significant and persistent decrease in motor and sensory function in the contralateral limb following pyramidotomy, as demonstrated by performance in the single pellet reaching task and the foot-fault test. There was no operative mortality or loss of respiratory function in this study. These results indicate that photothrombotic pyramidotomy with a dorsal transcortical approach is a safe and reliable technique for generating a pyramidotomy model with persistent motor deficits.

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Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

Cited by 4 publications

References 13 publications

Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery

Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery

Rehabilitative Training in Animal Models of Spinal Cord Injury

Transcortical photothrombotic pyramidotomy model with persistent motor deficits

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