Effects of B cell–activating factor on tumor immunity

Yarchoan, Mark; Ho, Won Jin; Mohan, Aditya; Shah, Yajas; Vithayathil, Teena; Leatherman, James M.; Dennison, Lauren; Zaidi, Neeha; Ganguly, Sudipto; Woolman, Skylar; Cruz, Kayla; Armstrong, Todd D.; Jaffee, Elizabeth M.

doi:10.1172/jci.insight.136417

Cited by 30 publications

(30 citation statements)

References 54 publications

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“…We then identified five genes related to prognosis after screening genes with different methylation and transcriptional expression levels in the C3 subtype. The expression levels of four of these five genes (GBP4, CTSS, TNFSF13B, RARRES3, and TAPBP) were closely related to immunotherapy, according to validation in the GEO database and the results of previous studies (35)(36)(37)(38)(39). These results suggest that increasing the expression of immune checkpoint genes via epigenetic therapy can reverse the immunosuppressive microenvironment of OC and enhance the efficacy of immunotherapy (40,41).…”

Section: Discussionmentioning

confidence: 65%

Comprehensive Landscape of Ovarian Cancer Immune Microenvironment Based on Integrated Multi-Omics Analysis

et al. 2021

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Epithelial ovarian cancer has a low response rate to immunotherapy and a complex immune microenvironment that regulates its treatment outcomes. Understanding the immune microenvironment and its molecular basis is of great clinical significance in the effort to improve immunotherapy response and outcomes. To determine the characteristics of the immune microenvironment in ovarian cancer, we stratified ovarian cancer patients into three immune subtypes (C1, C2, and C3) using immune-related genes based on gene expression data from The Cancer Genome Atlas and found that these three subtypes had significant differences in immune characteristics and prognosis. Methylation and copy number variant analysis showed that the immune checkpoint genes that influenced immune response were significantly hypermethylated and highly deleted in the immunosuppressive C3 subtype, suggesting that epigenetic therapy may be able to reverse the efficacy of immunotherapy. In addition, the mutation frequencies of BRCA2 and CDK12 were significantly higher in the C2 subtype than in the other two subtypes, suggesting that mutation of DNA repair-related genes significantly affects the prognosis of ovarian cancer patients. Our study further elucidated the molecular characteristics of the immune microenvironment of ovarian cancer, which providing an effective hierarchical method for the immunotherapy of ovarian cancer patients, and has clinical relevance to the design of new immunotherapies and a reasonable combination strategies.

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Section: Discussionmentioning

confidence: 65%

Comprehensive Landscape of Ovarian Cancer Immune Microenvironment Based on Integrated Multi-Omics Analysis

et al. 2021

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“…In HNSCC patients, TILs have stronger anti-cancer activity than peripheral blood Treg cells 27,28 . Recent studies have shown that B cells and plasma B cells located in tumors or the tumordraining lymph nodes play an important role in the formation of anti-tumor immune responses 29 . Moreover, T cells and B cells interact and coordinate their selection, specialization, and clonal expansion in tumor-associated tertiary lymphoid structures 30,31 ; the resulting plasma B cells are crucial to the antitumor immune response.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Role of DFNA5 in Head and Neck Squamous Cell Carcinoma Revealed by Systematic Expression Analysis

Liu¹,

Liu²,

Dong³

et al. 2020

Preprint

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The gasdermin E gene (GSDME, also known as DFNA5) is mutated in familial aging-related hearing loss. Recent studies have also revealed that the expression of DFNA5 is suppressed in many cancer types; however, little is known about the function of DFNA5 in head and neck squamous cell carcinoma (HNSCC). Accordingly, the aim of the present study was to evaluate the expression of DFNA5 and explore its prognostic value in HNSCC. We used a set of bioinformatics tools, including Oncomine, TIMER, TISIDB, cBioPortal, and GEPIA, to analyze the expression of DFNA5 in patients with HNSCC from public databases. Kaplan-Meier plotter was used to evaluate the potential prognostic significance of DFNA5. DFNA5 mRNA levels were significantly higher in HNSCC tissues than in normal tissues, and high DFNA5 expression was correlated with worse survival. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses showed that DFNA5 expression has a strong positive correlation with cell adhesion and the integrin signaling pathway, whereas its expression was negatively correlated with the levels of infiltrating B cells (cor = –0.223, P = 8.57e-07) and CD8 T cells (cor = –0.223, P = 2.99e-07). Overall, this study demonstrates that DFNA5 expression has prognostic value for HNSCC patients. Moreover, these results suggest that regulation of lymphocyte infiltration is the mechanism underlying the function of DFNA5 in HNSCC.

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“…Mast cells may also have the ability to express B cell-activating factor (BAFF) and TNF-related apoptosis inducing ligand (TRAIL) [ 67 , 68 ]. Exogenous BAFF slows B16-F10 melanoma growth in vivo and drives T H 1 responses potentially further enhancing anti-tumor immune responses [ 69 ]. However, in the setting of breast cancer, BAFF and the related mediator, APRIL, may promote metastasis [ 70 ].…”

Section: Mast Cell Key Mediators That Influence Cutaneous and Mammary Tumorsmentioning

confidence: 99%

Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role

Hanes

Giacomantonio

Marshall

2021

Cells

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Mast cells are important sentinel cells in host defense against infection and major effector cells in allergic disease. The role of these cells in cancer settings has been widely debated. The diverse range of mast cell functions in both immunity and tissue remodeling events, such as angiogenesis, provides multiple opportunities for mast cells to modify the tumor microenvironment. In this review, we consider both skin and breast cancer settings to address the controversy surrounding the importance of mast cells in the host response to tumors. We specifically address the key mediators produced by mast cells which impact tumor development. The role of environmental challenges in modifying mast cell responses and opportunities to modify mast cell responses to enhance anti-tumor immunity are also considered. While the mast cell’s role in many cancer contexts is complicated and poorly understood, the activities of these tissue resident and radioresistant cells can provide important opportunities to enhance anti-cancer responses and limit cancer development.

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Effects of B cell–activating factor on tumor immunity

Cited by 30 publications

References 54 publications

Comprehensive Landscape of Ovarian Cancer Immune Microenvironment Based on Integrated Multi-Omics Analysis

Comprehensive Landscape of Ovarian Cancer Immune Microenvironment Based on Integrated Multi-Omics Analysis

Prognostic Role of DFNA5 in Head and Neck Squamous Cell Carcinoma Revealed by Systematic Expression Analysis

Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role

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