Effects of Autologous Platelets Rich Plasma on Full-thickness Cutaneous Wounds  Healing in Goats

AL-Bayati, Ahmed H. F.; Al-Asadi, Rahi Nahi; Mahdi, A. K.; Al-Falahi, N. H.

doi:10.19026/ijava.5.5603

Cited by 15 publications

(20 citation statements)

References 18 publications

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“…In experimental studies in horses on PRP treatment of cutaneous wounds of the extremities, which are resistant to healing and resemble chronic ulcers in humans, Carter and colleagues found that PRP improved the quality of healing by producing organized collagen bundles as in the present study, and by accelerating epithelial differentiation, whereas Monteiro and colleagues reported that PRP slowed wound healing significantly (less exuberant granulation tissue) but no significant differences in histological variables were revealed between PRP-treated and untreated wounds (21,22). On the other hand, the use of autologous PRP for the closure of 3x3 cm full-thickness cutaneous wounds in goats accelerated the healing process in comparison to control wounds (41). In a similar experimental study in rabbits in acute wounds treated with PRP, a trend towards increased angiogenic response and epithelialization was reported, whereas in our study no significant differences in these variables were found between PRPtreated and control wounds (15).…”

Section: Controlsupporting

confidence: 46%

Effect of locally injected autologous platelet-rich plasma on second intention wound healing of acute full-thickness skin defects in dogs

Karayannopoulou¹,

Psalla²,

Kazakos³

et al. 2015

Vet Comp Orthop Traumatol

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Section: Controlsupporting

confidence: 46%

Effect of locally injected autologous platelet-rich plasma on second intention wound healing of acute full-thickness skin defects in dogs

Karayannopoulou¹,

Psalla²,

Kazakos³

et al. 2015

Vet Comp Orthop Traumatol

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“…Use of PRP in animals is steadily increasing, and its effects on tissue healing have been reported in many studies, particularly in bone regeneration and ligament or tendon reconstruction. Some studies have also described its healing effects in cutaneous wounds in dogs [ 2 18 27 ], goats [ 1 ], horses [ 7 23 ], and other species [ 10 19 ]. In both humans and animals, PRP is commonly processed for application to cutaneous wounds by mixing with calcium chloride and thrombin to form a platelet gel, which can be applied like an ointment [ 5 16 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…A gel formulation is easy to use but has certain disadvantages, particularly in animals, such as uneven distribution at movable body parts, possible loss, limited accessibility to the wound surface, and limited duration of effect. Therefore, injection of PRP has been used in orthopedic procedures, cosmetic surgery, and cutaneous wounds [ 1 3 10 26 ]. The present study was conducted to investigate the efficacy of intralesional injection of PRP in cutaneous wounds in dogs by evaluating tissue healing parameters.…”

Section: Introductionmentioning

confidence: 99%

Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs

et al. 2016

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This study was conducted to identify the effectiveness of platelet-rich plasma (PRP) and efficacy of intralesional injection as a method of application to acute cutaneous wounds in dogs. Healthy adult beagles (n = 3) were used in this study. Autologous PRP was separated from anticoagulant treated whole blood in three dogs. Cutaneous wounds were created and then treated by intralesional injection of PRP in the experimental group, while they were treated with saline in the control group on days 0, 2 and 4. The healing process was evaluated by gross examination throughout the experimental period and histologic examination on day 7, 14 and 21. In PRP treated wounds, the mean diameter was smaller and the wound closure rate was higher than in the control. Histological study revealed that PRP treated wounds showed more granulation formation and angiogenesis on day 7, and faster epithelialization, more granulation formation and collagen deposition were observed on day 14 than in control wounds. On day 21, collagen deposition and epithelialization were enhanced in PRP treated groups. Overall, PRP application showed beneficial effects in wound healing, and intralesional injection was useful for application of PRP and could be a good therapeutic option for wound management in dogs.

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“…Although the forest plot in Fig 3 showed two studies with not significant negative ES [ 51 , 53 ], two studies with null ES [ 30 , 46 ], seven studies with not significant positive ES [ 42 , 44 , 45 , 50 , 52 , 56 , 58 ] and four studies with significant positive ES [ 43 , 54 , 55 , 57 ]: the exclusion of each of the studies, in the sensitivity analysis, would have no relevant effect on the overall results of the meta-analysis supporting the efficacy of PRP for primary outcome. ( Fig 4 )…”

Section: Resultsmentioning

confidence: 99%

“…This finding is associated with a moderate degree of heterogeneity. The quality of evidence obtained in the meta-analysis for the primary outcome was demonstrated by sensitivity analysis, excluding alternately each of the studies, even showing negative ES [ 51 , 53 ], null ES [ 30 , 46 ], or statistically positive ES [ 43 , 54 , 55 , 57 ]: no relevant changes occurred in the results of the meta-analysis of primary outcome, persisting in statistical agreement with the hypothesis that supports the superiority of the PRP group. The sensitivity analysis finds its own indication in the identification of potential "outlier studies".…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis

et al. 2018

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The objective of the study was to review current literature to determine whether the topical application of platelet-rich plasma (PRP) promotes healing in experimentally-induced full-thickness skin wounds in animals. The hypothesis was that the adjunct of PRP has a positive effect on wound healing. An electronic search was carried out on the following databases: Web of Science, Cochrane Library, PubMed, Research Gate, Cochrane Wounds Group, Veterinary Information Network. No publication date nor language restrictions were applied. Randomised and not randomised controlled clinical trials comparing PRP with placebo or with other treatments were included. The reduction of open wound area in PRP-treated (test) wounds compared to control wounds was the primary outcome. Secondary outcomes were healing time and number of healed cases in test group compared to control. The following effect sizes were calculated: the Hedges’ g for continuous variables; the odds ratio for binary data. Eighteen controlled clinical trials were included in the qualitative and quantitative synthesis, with a total of 661 wounds. All studies were published in the period 2007–2016. Eight studies were carried out on rodent/lagomorph mammals and 10 on non-rodent/lagomorph mammals. In all included studies, control wounds underwent placebo or were left untreated. The PRP group showed a better healing performance than the control group in each outcome. The effect size was statistically significant considering the primary outcome and the overall aggregation of the three outcomes. The effect size, although in favour of the treatment with PRP, was not significant considering the healing time and the number of healings. The overall heterogeneity was mild or moderate. Five studies reported a high risk of selection bias. The publication bias was always mild or absent. The results support the hypothesis of the positive effects of the PRP when compared to control groups in the treatment of experimentally-induced full-thickness skin wounds in animals. PRP can therefore be considered an effective adjunctive therapy in stimulating second intention healing of acute wounds in healthy animals.

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Effects of Autologous Platelets Rich Plasma on Full-thickness Cutaneous Wounds Healing in Goats

Cited by 15 publications

References 18 publications

Effect of locally injected autologous platelet-rich plasma on second intention wound healing of acute full-thickness skin defects in dogs

Effect of locally injected autologous platelet-rich plasma on second intention wound healing of acute full-thickness skin defects in dogs

Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs

Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis

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