Effects of atrial fibrillation on complications and prognosis of patients receiving emergency PCI after acute myocardial infarction

Abstract

The effects of atrial fibrillation on complications and prognosis of patients receiving emergency percutaneous coronary intervention after acute myocardial infarction (AMI) were investigated. Eighty AMI patients treated with interventional vascular recanalization in the Affiliated Hospital of Weifang Medical University (Weifang, China) from July 2015 to October 2016 were selected, including 40 patients complicated with atrial fibrillation before operation (control group) and 40 patients without atrial fibrillation before operation (observation group). The systolic blood pressure, diastolic blood pressure, heart rate, arrhythmia and common complications after MI were compared. Changes in the coronary artery thrombolysis in myocardial infarction (TIMI) flow grade and left ventricular ejection fraction (LVEF) of patients were also recorded. Moreover, changes in brain natriuretic peptide (BNP) levels were compared. The recovery time of myocardial enzyme and total troponin in both groups was recorded. The systolic and diastolic blood pressure in the observation group were significantly higher than those in the control group (p<0.05). During the intervention, the total proportion of patients with ventricular arrhythmia, atrial arrhythmia, atrioventricular block and sinus tachycardia in the observation group was significantly lower than that in the control group (p<0.05). The total proportion of common complications after MI in the observation group was obviously lower than that in the control group (p<0.05). Coronary artery TIMI flow grades and LVEFs in the observation group were obviously higher than those in the control group. BNP levels in the observation group were significantly lower than those in the control group. The recovery time of myocardial enzyme and total troponin in the observation group was significantly earlier than that in the control group. Atrial fibrillation has a certain negative effect on the circulatory function in patients with AMI after the interventional therapy, and the proportions of arrhythmia and complications in patients after MI are increased at the same time, so the postoperative recovery of patients is slow with many complications.

Effects of sodium tanshinone IIA sulfonate injection on inflammatory factors and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A systematic review and meta-analysis of randomized clinical trials

“…Four trials did not belong to RCTs ( Ye, 2019 ; Li, 2020 ; Wen and LYU, 2020 ; Zhao et al, 2022 ), three trials had duplicate data ( Luan, 2012 ; Pang, 2016 ; He and Wang, 2019 ), and another four trials did not include outcomes that met the criteria ( Lin, 2012 ; Mao et al, 2015a ; Mao et al, 2015b ; Zhou et al, 2016 ). Ultimately, 17 trials ( Du and Wang, 2011 ; Luan and Pan, 2012 ; Wu et al, 2015 ; He, 2016 ; Li, 2016 ; Chen et al, 2017 ; Lin et al, 2017 ; Du et al, 2018 ; Luo, 2018 ; Pang et al, 2019 ; Tao et al, 2019 ; Zhang and Jin, 2019 ; Lian, 2020 ; Lu et al, 2021 ; Mao et al, 2021 ; Zheng et al, 2021 ; Yu et al, 2022 ) were deemed qualified for the meta-analysis. The PRISMA flow chart of the trial selection process is shown in Figure 1 .…”

“…Most studies reported the results of inflammatory factors and vascular endothelial function in detail, among which the more commonly used indicators were analyzed. Ten trials (Du and Wang, 2011;He, 2016;Li, 2016;Du et al, 2018;Luo, 2018;Zhang and Jin, 2019;Lian, 2020;Lu et al, 2021;Mao et al, 2021; reported MACE information. In addition, ten trials reported adverse events, of which four (Chen et al, 2017;Lin et al, 2017;Luo, 2018;Tao et al, 2019) reported no adverse events and the remaining six (He, 2016;Li, 2016;Pang et al, 2019;Lian, 2020;Zheng et al, 2021; reported a total of 28 adverse events.…”

“…All of the trials mentioned randomization, 12 trials (Wu et al, 2015;He, 2016;Li, 2016;Chen et al, 2017;Lin et al, 2017; Frontiers in Pharmacology frontiersin.org Luo, 2018;Tao et al, 2019;Zhang and Jin, 2019;Lian, 2020;Lu et al, 2021;Mao et al, 2021; mentioned the use of random sequence methods such as random number tables, computer-generated random numbers, or central random systems, and four of them (He, 2016;Li, 2016;Lian, 2020;Mao et al, 2021) also mentioned methods of assigning concealment and were therefore considered "low risk." For "bias due to deviating from expected interventions," two trials (Lian, 2020;Mao et al, 2021) were rated "low risk" because they used blinding for subjects, operators, and outcome evaluators.…”

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization

“…Early percutaneous coronary intervention (PCI) can restore blood flow to ischemic myocardium, decrease infarct size, and reduce mortality and complications [1], but about 10-30% of patients exhibit no-reflow or slowreflow phenomena after PCI, which seriously affects prognosis [2]. The main cause of no-reflow or slow-reflow after PCI is coronary microembolism (CME) [3], resulting in myocardial cell necrosis and apoptosis, ventricular remodeling, malignant arrhythmia, and cardiac failure [4]. No drugs or mechanical devices are currently available to prevent CME, and remedial measures after the occurrence of CME have only a limited impact on the development of arrhythmias and prognosis [5].…”

Cardiorenal relationships in the focus of risks of atrial fibrillation in patients after acute ST-elevated myocardial infarction (observational program FAKEL)

“…По данным исследований риск развития ФП у пациентов с острым инфарктом миокарда (ИМ) с подъемом сегмента ST (ИМпST) превышает 15% [4]. Известно, что ФП, возникшая во время ИМ, а также в раннем периоде после чрескожного коронарного вмешательства (ЧКВ), статистически значимо ухудшает прогноз выживаемости пациентов [5]. Данное обстоятельство, в первую очередь, обусловлено прогрессивным ухудшением кровоснабжения синоатриального узла, усугублением степени ишемии миокарда, развитием гипоксии и нарастанием сердечной недостаточности [6][7][8].…”