Noninvasive positive pressure ventilation is safe for selected patients with acute lung injury. However, a larger randomized trial with need for intubation and mortality as the outcomes of interest is required.

A novel palladium-catalyzed oxidative carbonylation reaction was developed via the carbon monoxide insertions between the amine group and the carbonyl group to realize the intramolecular cyclization, which provides efficient access to 1,3,4-oxadiazol-2(3H)-ones with a wide range of substrates under mild conditions, resulting in good to excellent yields.

Background: Coronary microembolization (CME) has a poor prognosis, with ventricular arrhythmia being the most serious consequence. Understanding the underlying mechanisms could improve its management. We investigated the effects of granulocyte colony-stimulating factor (G-CSF) on connexin-43 (Cx43) expression and ventricular arrhythmia susceptibility after CME. Methods: Forty male rabbits were randomized into four groups (n = 10 each): Sham, CME, G-CSF, and AG490 (a JAK2 selective inhibitor). Rabbits in the CME, G-CSF, and AG490 groups underwent left anterior descending (LAD) artery catheterization and CME. Animals in the G-CSF and AG490 groups received intraperitoneal injection of G-CSF and G-CSF + AG490, respectively. The ventricular structure was assessed by echocardiography. Ventricular electrical properties were analyzed using cardiac electrophysiology. The myocardial interstitial collagen content and morphologic characteristics were evaluated using Masson and hematoxylin-eosin staining, respectively. Results: Western blot and immunohistochemistry were employed to analyze the expressions of Cx43, G-CSF receptor (G-CSFR), JAK2, and STAT3. The ventricular effective refractory period (VERP), VERP dispersion, and inducibility and lethality of ventricular tachycardia/fibrillation were lower in the G-CSF than in the CME group (P < 0.01), indicating less severe myocardial damage and arrhythmias. The G-CSF group showed higher phosphorylated-Cx43 expression (P < 0.01 vs. CME). Those G-CSF-induced changes were reversed by A490, indicating the involvement of JAK2. G-CSFR, phosphorylated-JAK2, and phosphorylated-STAT3 protein levels were higher in the G-CSF group than in the AG490 (P < 0.01) and Sham (P < 0.05) groups. Conclusion: G-CSF might attenuate myocardial remodeling via JAK2-STAT3 signaling and thereby reduce ventricular arrhythmia susceptibility after CME.

A copper-catalyzed formation of C-N/N-N bonds using Nphenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environmentally benign with a large substrate scope available and represents an economical path for numerous C-N/N-N bond formations.

A novel and simple t‐BuOLi/I2‐mediated synthesis of 1,2,4‐trisubstituted imidazoles was developed without transition‐metal added. The transition‐metal‐free strategy tolerated a range of substrates and provided products in moderate to good yields with 100% regioselectivity.

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A novel and air-stable organo(hydro)diborane featuring a five-membered aryl ring supported bridging B–C–B three-centre–two-electron (3c–2e) bond has been reported. Pyrido[1,2-a]isoindole was found to undergo a stepwise BH3 addition reaction, during...

The efficiency of on-site consumption of new energy and the economy of dispatching strategy for that in modern microgrids are increasingly concerning, which are closely related to the microgrid control model with source-load uncertainty. To this end, this paper proposes the multiagent hierarchical IQ (λ)-HDQC regulation strategy to realize the source-load-storage-charging collaborative control of the microgrid model with high-permeable new energy. The first layer adopts the IQ (λ) strategy, which avoids the overestimation and underestimation problems of traditional reinforcement learning by the coupled estimation method. The second layer adopts the HDQC allocation strategy, which solves the problem of low utilization of new energy in the proportional allocation method and improves the adaptability of the regulation strategy in the complex stochastic environment. The interaction of the two-layer strategies realizes the source-network-load-storage-charge global dynamic interactive regulation of microgrids. Indicators of energy efficiency are constructed in this paper to measure the simulation results. And the superiority of the proposed strategy is verified through the simulation results of the microgrid system.