Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

Brili, Stella; Tousoulis, Dimitris; Antonopoulos, Alexios S.; Antoniades, Charalambos; Hatzis, George; Bakogiannis, Constantinos; Papageorgiou, Nikolaos S.; Stefanadis, Christodoulos

doi:10.1136/heartjnl-2011-300287

Cited by 33 publications

(11 citation statements)

References 27 publications

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“…Two recent prospective drug trials in patients after coarctation repair have provided evidence that impairment of endothelial function may, in fact, be reversible. Four weeks of treatment with an ACE inhibitor26 or a HMG-CoA reductase inhibitor27 resulted in markedly increased FMD, while levels of proinflammatory cytokines and soluble adhesion molecules decreased.…”

Section: Discussionmentioning

confidence: 96%

Endothelial function in contemporary patients with repaired coarctation of aorta

Duck

et al. 2014

Heart

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Section: Discussionmentioning

confidence: 96%

Endothelial function in contemporary patients with repaired coarctation of aorta

Duck

et al. 2014

Heart

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“…investigated the effects of atorvastatin on endothelial function and low-grade systemic inflammation in subjects with successful surgery for aortic coarctation repair (SCR). According to their results, the treatment with atorvastatin was proven significantly beneficial for the subjects, since it was shown to improve endothelial function and decrease circulating levels of proatherogenic inflammatory cytokines, IL-1b, adhesion molecules, and sVCAM-1, meliorating thus the suppressed systemic inflammatory status [25]. …”

Section: Clinical Evidence Of Statins’ Anti-inflammatory Effectmentioning

confidence: 99%

The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature

Diamantis

Kyriakos

Quiles-Sánchez

et al. 2017

CCR

166

108

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Background:Statins have long been used for the protection against coronary artery disease (CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic properties. Emerging evidence from laboratory studies and clinical trials as well have pointed out the pivotal role of inflammation on the initiation and exacerbation of atherosclerosis; a major cause of CAD. Inflam-mation markers such as high sensitivity C-reactive protein and adhesion molecules are shown to in-crease in CAD patients and are used as prognostic tools. It is well known that statins can actually re-duce the circulating levels of these agents slowing therefore the inflammatory process; interestingly not all types have the same outcome.Conclusion:The anti-inflammatory effect of statins on the formation of atherosclerotic plaque and the function of endothelial cells is thus of particular importance as these agents can actually ameliorate CAD prognosis

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“…[9][10][11] Pleiotropic effects may include antifibrotic and antihypertrophic effects, upregulation of endothelial NO production, vasodilation and decreased platelet aggregation, 12 inhibition of inflammatory cytokines and neurohormonal activation, and reversal of myocardial remodeling. [13][14][15][16] However, effects in HF with reduced ejection fraction (HFREF) are more controversial, [17][18][19] and the randomized Controlled Rosuvatatin Multinational Trial in Heart Failure (CORONA) and Gruppo Italiano per lon Studio della Sopravvivenza Nell Insufficienza Cardia (GISSI) did not demonstrate benefits of statins. 20,21 …”

mentioning

confidence: 99%

Association Between Use of Statins and Outcomes in Heart Failure With Reduced Ejection Fraction

Alehagen

Benson

Edner

et al. 2015

Circ: Heart Failure

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Background-In heart failure (HF) with reduced ejection fraction, randomized trials of statins did not demonstrate improved outcomes. However, randomized trials may not always be generalizable. The aim was to determine whether statins are associated with improved outcomes in an unselected nationwide population of patients with HF with reduced ejection fraction overall and in relation to ischemic heart disease (IHD). Methods and Results-In the Swedish Heart Failure Registry, 21 864 patients with HF with reduced ejection fraction (age ± SD, 72±12 years; 29% women), of whom 10 345 (47%) were treated with statins, were studied. Propensity scores for statin use were derived from 42 baseline variables. The associations between statin use and outcomes were assessed with Cox regressions in a population matched 1:1 based on propensity score and age and in the overall population with adjustment for propensity score and age. The primary outcome was all-cause mortality; secondary outcomes were cardiovascular mortality; HF hospitalization; and combined all-cause mortality or cardiovascular hospitalization. Survival at 1 year in the matched population was 83% for statin-treated versus 79% for untreated patients (hazard ratio, 0.81; 95% confidence interval, 0.76-0.86; P<0.001). In the unmatched population, 1-year survival was 85% for statin-treated versus 79% for untreated patients, hazard ratio after adjustment for propensity score and age was 0.

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Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

Abstract: Atorvastatin treatment for 4 weeks in subjects with SCR significantly improved endothelial function and suppressed systemic inflammatory status by decreasing circulating levels of IL-1b and sVCAM-1.

Cited by 33 publications

References 27 publications

Endothelial function in contemporary patients with repaired coarctation of aorta

Endothelial function in contemporary patients with repaired coarctation of aorta

The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature

Association Between Use of Statins and Outcomes in Heart Failure With Reduced Ejection Fraction

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