Effects of Aspirin and Acetaminophen on Fetal and Placental Growth in Rats

Lubawy, William C.; Garrett, R.J. Burriss

doi:10.1002/jps.2600660129

Cited by 26 publications

(6 citation statements)

References 14 publications

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“…With few exceptions, the present findings are similar to those produced by other investigators using salicylates in multiple dose paradigms in rats (Baba et al, 1966; Schardein et al, 1969; Beall and Klein, 1976; Lubawy and Burriss Garrett, 1977; Nakatsuka and Fuji, 1979; Mankes et al, 1982; Hamed et al, 1994). Baba et al (1966) produced two MDs at a 330‐mg/kg dose administered from GD 9 to 14.…”

Section: Discussionsupporting

confidence: 91%

“…Baba et al (1966) produced two MDs at a 330‐mg/kg dose administered from GD 9 to 14. Lubawy and Burriss Garrett (1977) administered ASA at doses of 125 and 250 mg/kg from GD 8 to 19 to rats. Decreased maternal body weights, increased numbers of resorptions accompanied by decreases in the number of viable fetuses, and decreased fetal and placental weights were noted at 250‐mg/kg dose level.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of developmental toxicology of aspirin (Acetylsalicylic Acid) in rats using selected dosing paradigms

Gupta

Cook

Tassinari

et al. 2003

Birth Defects Research Pt B

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High concordance in major developmental anomalies between Wistar and SD rats were noted with the exception of VSD in the SD rats and hydrocephalus in the Wistar rats. Variations and malformations were similar when ASA was administered as a single dose or during the period of organogenesis (GDs 6 to 17). It was also evident that, by titrating the dose to achieve a maximum tolerated dose, malformations that normally occur at low incidence, as reported from previous single dose studies, could also be induced with ASA given at multiple doses.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of developmental toxicology of aspirin (Acetylsalicylic Acid) in rats using selected dosing paradigms

Gupta

Cook

Tassinari

et al. 2003

Birth Defects Research Pt B

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show abstract

“…40 Lubawy and Garrett treated rats once daily with paracetamol at doses 125 or 250 mg/kg/day between days 8 and 19 of rat pregnancy and did not observe any signs of developmental toxicity. 41 However, when paracetamol was administered three times a day it caused intrauterine growth retardation, reducing fetal weight and length at doses 50, 100 and 200 mg/kg, whereas the placental weight and tail length were increased in the highest drug-treatment group. 42 Data on maternal toxicity, pre-and postnatal losses and bone changes were similar to those in the present study.…”

Section: Discussionmentioning

confidence: 99%

Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol

Burdan

2004

Hum Exp Toxicol

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The aim of the study was to determine the influence of an over-the-counter (OTC) mixture of propyphenazone with caffeine or paracetamol on prenatal development. Propyphenazone:caffeine and propyphenazone:paracetamol mixtures were prepared with constant 3:1 and 3:5 ratios, respectively. Three dose levels of each of the mixtures were administered separately in Tween-80 water suspension once a day to pregnant Wistar rats on gestation days 8-14. The low dose was similar to the OTC preparations, 2.1 mg/kg of propyphenazone, 0.7 mg/kg of caffeine or 3.5 mg/kg of paracetamol. The middle dose was 21.0, 7.0 or 35.0 mg/kg, and the highest 210.0, 70.0 or 350.0 mg/kg for propyphenazone, caffeine or paracetamol, respectively. On day 21 of gestation the fetuses were delivered by hysterectomy. Dead or live fetuses, resorptions and the number of implantation sites were counted. Live fetuses were examined for external, visceral and skeletal malformation. Postimplantation mortality was calculated. Dose-dependent effects in the middle and high dose groups on fetal body weight/length and placental weight were found. No increase in external or internal congenital anomalies was found in any of the mixture-exposed groups. Prenatal coadministration of propyphenazone with caffeine or paracetamol caused intrauterine growth retardation but did not increase external or internal congenital anomalies. The risk of midline defects (umbilical hernia and gastroschisis) is discussed.

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“…Biologic plausibility stems from animal models, which have demonstrated that reduced fetal length in rat pups is associated with mid-gestation maternal exposure to 125 mg and 350 mg of acetaminophen, dosage comparable to maternal use. (12, 13) Various concentrations of acetaminophen have been associated with morphological changes in the fetal liver. It has been hypothesized that insults to the fetal liver may result in the reduction of blood stem cells to key organs, resulting in increased risk of adverse growth and development.…”

Section: Introductionmentioning

confidence: 99%

Comparison of fetal growth by maternal prenatal acetaminophen use

Smarr

Bible

Gerlanc³

et al. 2019

Pediatr Res

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Background: Equivocal findings exist regarding prenatal acetaminophen use and various adverse neonatal and childhood health outcomes, though with no data on fetal growth. We evaluated whether fetal growth differed by maternal acetaminophen use. Methods: Racially diverse, healthy women with low-risk antenatal profiles from 12 U.S. clinical centers were enrolled in a prospective cohort study and followed until delivery. Ultrasound measurements of fetal parameters and self-reported prenatal acetaminophen use were collected at enrollment and up to 5 follow-up visits. Prenatal acetaminophen use was dichotomized as none or any. Results: Among2,291 women, 932 (41%) reported the use of acetaminophen medications during the current pregnancy. Estimated growth curves of fetal parameters did not differ between women reporting use of any medication containing acetaminophen and women with no reported use of the same. Conclusion: Among healthy mothers with low-risk pregnancies, maternal acetaminophen use was not associated with alterations in fetal growth.

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Effects of Aspirin and Acetaminophen on Fetal and Placental Growth in Rats

Cited by 26 publications

References 14 publications

Comparison of developmental toxicology of aspirin (Acetylsalicylic Acid) in rats using selected dosing paradigms

Comparison of developmental toxicology of aspirin (Acetylsalicylic Acid) in rats using selected dosing paradigms

Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol

Comparison of fetal growth by maternal prenatal acetaminophen use

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