Comparison of developmental toxicology of aspirin (Acetylsalicylic Acid) in rats using selected dosing paradigms

Abstract

High concordance in major developmental anomalies between Wistar and SD rats were noted with the exception of VSD in the SD rats and hydrocephalus in the Wistar rats. Variations and malformations were similar when ASA was administered as a single dose or during the period of organogenesis (GDs 6 to 17). It was also evident that, by titrating the dose to achieve a maximum tolerated dose, malformations that normally occur at low incidence, as reported from previous single dose studies, could also be induced with ASA given at multiple doses.

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

“…We also performed an intrauterine exposure study with acetylsalicylic acid, which resulted in shorter AGD in all male fetuses compared with controls. However, as expected from previous experiments (Gupta et al, 2003), acetylsalicylic acid also resulted in intrauterine fetal growth retardation to such a degree that the difference in AGD was undetectable after adjusting for body weight (Supplementary data, Table SIV). Examination of testosterone production by the testes exposed in utero to acetylsalicylic acid showed a significant (P , 0.05) and not significant (P ¼ 0.065 and 0.077) reduction, compared with unexposed control testes (Supplementary data, Table SV).…”

“…Compounds were administered by gavage from GD13 to 21 and Caesarean section at GD21 using Wistar rats. Paracetamol was administrated in subtoxic doses of 150, 250 and 350 mg/kg/ day (Ghanem et al, 2009), whereas acetylsalicylic acid was administered in doses of 150, 200 and 250 mg/kg/day with a lower top dose due to its known adverse effect on pregnancies (Gupta et al, 2003). For doseresponse analysis, AGD data were analysed by the calculated AGD index (AGDi), defined as AGD divided by the cube root of the body weight (Gallavan et al, 1999).…”

Prenatal Developmental Toxicity Study of HEA-enriched Cordyceps Cicadae Mycelia in Sprague-Dawley Rats

“…All treatment groups exposed to HEA-enriched C. cicadae mycelia did not differ from the negative control group in terms of body weight gain and level of food and water consumption (data not shown). In contrast, treatment with aspirin (positive control) profoundly showed weight loss in the pregnant rats, accounting for the differences in body weight when compared to the negative control group on the 20 th day (p<0.05), which were in accordance with findings from a previous study [22].…”

“…Using a random number generator (Excel; Microsoft, Redmond, WA), the experimental animals were divided randomly into 5 groups (a minimum of 20 animals per group) as follows: three dosages test groups, one negative control group and one positive group. The negative control group received vehicle treatment (10 ml/kg distilled water daily), the positive control group received 10 ml/kg aspirin (SigmaAldrich) at a dosage of 250 mg/kg body weight (bw) [22] while the three dosages test groups received 10 ml/kg HEA-enriched C. cicadae mycelia at a dose of 500 (low dose), 1,000 (mid dose) and 1,500 (high dose) mg/kg bw, respectively. These dose levels were selected according to the previous chronic toxicity study [20] and were administered orally in the gestation of 6 to 15 days, which is defined as the critical period for early fetal structural development.…”

Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy

“…In the contemporary study, the medicine was administered systemically to evaluate the effect on the dental tissues of the neonates. Review of the literature indicated the potential association of NSAIDs with developmental toxicity of diaphragmatic hernia, midline defect and ventricular septal defects in rats and rabbits Gupta et al, 2003;Cook et al, 2003). The rate of perinatal mortality was reported providing the information of high-risk pregnancies, where aspirin treatment seemed to have a small but significant effect on reducing the rate of preterm deliveries, but did not reduce the rate of perinatal death (Kozer et al, 2003).…”