Effects of arachidonic acid supplementation on training adaptations in resistance-trained males

Abstract

Background: To determine the impact of AA supplementation during resistance training on body composition, training adaptations, and markers of muscle hypertrophy in resistance-trained males.

Efficacy and Safety of Arachidonic Acid for Treatment of Schistosoma mansoni-Infected Children in Menoufiya, Egypt

“…Treatment with PZQ or ARA alone or combined with PZQ led to similar effects on platelets counts, prothrombin time and concentration, international normalized ratio, and partial thromboplastin time values, suggesting that therapy of schoolchildren with 300-600 mg/day ARA for 15 days induced no adverse changes in blood coagulation and thrombocytic tendencies, which is in accordance with findings obtained previously in healthy adults. 30 Therapy of S. mansoni-infected children with PZQ decreased the levels of circulating IL-10 and IFN-γ and the amounts of IFN-γ released in whole-blood cultures stimulated in vitro with rSG3PDH, giving support to the hypothesis that treatment of schistosomiasis mansoni with PZQ can significantly alter the immune response of patients. 49 Treatment with ARA alone or combined with PZQ was more effective than PZQ in altering the immune responses of children toward reducing production of IL-10 and IFN-γ as early as 3 days after the end of treatment, consistent with the observational studies showing that higher ARA consumption was associated with lower levels of inflammatory markers.…”

“…Of note, 10 mg/kg ARA daily intake for 15 days over 3 weeks had no statistically significant effects on schoolchildren's serum levels of cholesterol or high-and low-density lipoproteins, supporting data recorded in adults given 1.7 g ARA daily for 50 days. 30 Similar to PZQ, ARA alone or combined with PZQ led to amelioration of the serum triglycerides, total proteins, direct bilirubin, and creatinine levels. The schoolchildren infected with S. mansoni showed evidence of anemia, confirming data obtained regarding S. mansoni-infected schoolchildren in eastern Sudan and Uganda.…”

“…29 Supplementation of 1 g ARA daily for 50 days was found to be well-tolerated in male athletes. 30 In this study, we present, for the first time, data on the efficacy and safety of the nutrient ARA in treatment of Egyptian children infected with S. mansoni.…”

Towards the optimization of performance of Atlantic salmon reared at different water temperatures via the manipulation of dietary ARA/EPA ratio

“…In humans, it has been shown that ARA and its metabolites play a key role in skeletal muscle growth and tissue regeneration in combination with physical activities (Kalish et al, 2013). Therefore, attention has risen to elucidate the key role of ARA and its metabolites in myogenesis, or skeletal muscle formation (Korotkova and Lundberg, 2014;Roberts et al, 2007). It has been demonstrated that the metabolisation of dietary ARA, via the cyclooxygenase (COX-2) pathways triggered by exercise and/or stress, induces eicosanoid production in muscle, which in turn regulates the skeletal muscle growth (Horsley and Pavlath, 2003;Markworth and Cameron-Smith, 2013).…”

Molecular Attributes of Human Skeletal Muscle at Rest and After Unaccustomed Exercise: An Age Comparison

“…The protein was then dissolved in 1 mL of 1.0% sodium dodecyl sulfate, and stored at 280°C until later protein analysis. It should be noted that this isolation procedure is designed to completely dissociate all (17,25,26).…”