2014
DOI: 10.4269/ajtmh.14-0328
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Abstract: Abstract. Arachidonic acid (ARA), an omega-6 fatty acid, kills juvenile and adult schistosomes in vitro and displays highly significant and safe therapeutic effects in mice and hamsters infected with Schistosoma mansoni or S. haematobium. This study aims to examine the efficacy and safety of ARA in treatment of school-age children infected with S. mansoni. In total, 66 S. mansoni-infected schoolchildren (20-23 children/study arm) received a single dose of 40 mg/kg praziquantel (PZQ), ARA (10 mg/kg per day for … Show more

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Cited by 21 publications
(36 citation statements)
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“…During the natural Schistosomiasis mansoni, hepatic steatosis and high AA stores seem much more related to host protection. This might be explained by the fact that AA is also an schistosomicide with significant therapeutic and safe effects in both experimental [58] and human schistosomiasis mansoni [59]. The killing effect of AA on S .…”
Section: Discussionmentioning
confidence: 99%
“…During the natural Schistosomiasis mansoni, hepatic steatosis and high AA stores seem much more related to host protection. This might be explained by the fact that AA is also an schistosomicide with significant therapeutic and safe effects in both experimental [58] and human schistosomiasis mansoni [59]. The killing effect of AA on S .…”
Section: Discussionmentioning
confidence: 99%
“…FA in serum PL and TAG were measured in fasted blood at four time points: baseline, after 2 and 4 weeks of supplementation and 4 weeks after the end of supplementation. Supplementation with ARA increased ARA content of serum PL from 9•6 to 13•7 (after 2 weeks) and 13•9 % (after 4 weeks) of total FA, which was significantly different from baseline, and then ARA content decreased to a level close to that Barakat et al (20) De Souza et al (21) Emken et al (22) Hirota et al (23) Ishikura et al (24) Kakutani et al (25) Kusumoto et al (26) Mitchell et al (27) ; Markworth et al (28) Nelson et al (13,14) ; Kelley et al (15,16) ; Ferreƫ et al (17) Pantaleo et al (29) Roberts et al (30) Schubert et al (31) Selim et al (32) Smit et al (33) Thies et al (34)(35)(36) Reference Fig. 4.…”
Section: Fatty Acid Composition In Different Compartments a Numbermentioning
confidence: 74%
“…Roberts et al (29) conducted a study in resistance-trained male subjects and found that serum cholesterol concentrations were not changed after ARA supplementation (1 g/d for 50 d). Likewise, there were no changes in serum concentrations of total, LDL-and HDL-cholesterol, TAG, apo AI, apo B or lipoprotein (a) after ARA supplementation in different study designs (see Table 2) in adults (14,25,27) and schoolchildren (19,31) .…”
Section: Effect Of Arachidonic Acid On Blood Lipid Concentrationsmentioning
confidence: 95%
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“…Arachidonic acid (ARA), which is a normal constituent of cell plasma membranes was studied in schoolchildren with light, moderate or heavy S. mansoni infection given a good performance in a proof-of-concept study in children with light infections [108]. ARA (10 mg/kg per day for 15 days) revealed moderate CRs (50% and 60%, respectively) against light infection and low CRs (21% and 20%, respectively) against heavy infection.…”
Section: Research and Development Of Antischistosomal Drugsmentioning
confidence: 99%