Effects of Antihypertensive Therapy on Glucose and Insulin Metabolism and on Left Ventricular Mass

Kuperstein, Rafael; Sasson, Zion

doi:10.1161/01.cir.102.15.1802

Cited by 30 publications

(16 citation statements)

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“…The results of several experimental and clinical studies indicate that angiotensin-converting-enzyme inhibitor effectively reduces left ventricular hypertrophy [Black et al 1996, Kobayashi et al 1990]. In comparison with other antihypertensive drugs, perindopril signifi cantly prevents the development of left ventricular hypertrophy in hypertensive patients and laboratory rats [Black et al 1996, Kuperstein andSasson 2000, C -control group, PR -group with perindopril, MT -group with metoprolol, ID -group with indapamide, AM -group with amlodipine, WBC -white blood cells, RBC -red blood cells, HGB -hemoglobin, HCT -hematocrit, Lym -lymphocytes, n -number of rats in the group. *Signifi cantly differences vs C group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Suliburska

Bogdański

Krejpcio

2014

Acta Sci Pol Technol Aliment

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Introduction. One side effect of antihypertensive drugs is their impact on nutritional status and metabolism. The purpose of this study was to assess the nutritional and biochemical parameters in spontaneously hypertensive rats following treatment with antihypertensive drugs. Material and methods. The experiment was performed on 50 male spontaneously hypertensive rats (SHR), which were assigned to fi ve groups: control (C), with perindopril (PR), with metoprolol (MT), with indapamide (ID), and with amlodipine (AM). All rats were provided ad libitum standard diet (with or without drugs) and distilled water. After 45 days, the animals were weighed and killed. Liver, kidney, heart, spleen, pancreas, and blood samples were collected. Concentrations of glucose, cholesterol, triglycerides, and albumin were assayed in serum. Morphology parameters, such as white blood cell, red blood cell, hematocrit, and lymphocyte counts were measured in the blood. Blood pressure was measured using a tail-cuff plethysmograph. Results. The results obtained indicate that the hypotensive drugs under investigation had no effect on the selected nutritional parameters. Perindopril signifi cantly decreased the relative mass of the heart and amlodipine markedly decreased the relative mass of the pancreas. A markedly higher concentration of glucose in the group with indapamid, and a signifi cantly lower concentration of triglycerides in the group with metoprolol, were observed. Indapamide and amlodipine markedly increased the value of red blood cells and hematocrit in the blood of SHR. Conclusions. Long-term therapy with antihypertension drugs may infl uence tissue mass and biochemical and morphological status in the body.

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Section: Discussionmentioning

confidence: 99%

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Suliburska

Bogdański

Krejpcio

2014

Acta Sci Pol Technol Aliment

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“…28,29 CCBs are known to be metabolically neutral, 30,31 and long-acting dihydropyridines CCBs have been reported to improve glucose tolerance and lower insulin levels. 32,33 Our results showed that fasting BG and LDL-C were significantly increased in hypertensive patients who received combination therapy of nitrendipine and atenolol, whereas insulin sensitivity and postprandial BG were not significantly articles Metformin Prevents a β-Blocker-Induced Weight Gain changed, suggesting that the mechanism of combination therapy of nitrendipine and atenolol in deteriorating BG and BL may be related to the action of atenolol.…”

Section: Metformin Prevents a β-Blocker-induced Weight Gainmentioning

confidence: 99%

Effect of Metformin on Weight Gain During Antihypertensive Treatment With a -Blocker in Chinese Patients

Zhang¹,

Zheng²,

Zou³

et al. 2009

American Journal of Hypertension

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“…It should be noted that high doses, for example, perindopril Various studies have shown that ACE inhibitors significantly 8mg were required to improve carotid structure and function in reduce LV mass index (LVMI) in patients with hypertension; [48][49][50][51][52][53] hypertensive patients with type 2 diabetes mellitus. The beneficial an effect which takes place within a few months of initiating effect of perindopril on arterial stiffness observed in the 3-month treatment with an ACE inhibitor and is seen to a greater extent study [65] was unlikely to have been the result of vascular remodelwith ACE inhibitors than other CCA [50] or β-blockers.…”

Section: Cardiac Remodelingmentioning

confidence: 99%

“…The beneficial an effect which takes place within a few months of initiating effect of perindopril on arterial stiffness observed in the 3-month treatment with an ACE inhibitor and is seen to a greater extent study [65] was unlikely to have been the result of vascular remodelwith ACE inhibitors than other CCA [50] or β-blockers. [49,52,53] ing, because of rapid onset of action and loss of effect after Beneficial effects on endothelial function have been observed discontinuation of therapy, and it is possible that the effect was after long-term use of various ACE inhibitors, [54][55][56][57][58][59][60][61][62] including attributable to improved endothelial function. Indeed, ACE inhibiperindopril.…”

Section: Cardiac Remodelingmentioning

confidence: 99%

ACE Inhibition in Hypertension

Cockcroft

2007

American Journal of Cardiovascular Drugs

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Ongoing developments in our understanding of cardiovascular disease, together with the introduction of new drugs to treat these conditions, has led to much debate over the optimal management of hypertension. The ALLHAT study showed no major differences in cardiovascular outcome among three major classes of antihypertensive drugs. Indeed, large meta-analyses have substantiated this view, and most experts would agree that BP reduction matters more than the choice of antihypertensive agent. However, recently published data from the ASCOT-BPLA trial for hypertensive patients at moderate risk of cardiac events have caused some experts to re-evaluate this view. The recent Blood Pressure Lowering Treatment Trialists' Collaboration publication confirmed this change. In the ASCOT-BPLA trial, antihypertensive therapy based on amlodipine+perindopril significantly reduced total and cardiovascular mortality as well as other clinically relevant outcomes in comparison with a traditional strategy based on atenolol and a thiazide diuretic, despite both regimens producing nonsignificantly different reductions in brachial BP. These findings suggest that amlodipine/perindopril may exert a beneficial effect by acting on other parameters such as central BP or BP variability. ACE inhibitors have been shown to have antiatherosclerotic and antithrombogenic effects, to improve endothelial dysfunction, and to prevent cardiac remodeling in patients with coronary heart disease. In this regard, perindopril, which has relatively high affinity for ACE and true 24-hour duration of action, is one of the most extensively studied ACE inhibitors. More recent data suggest that ACE inhibitors reduce arterial stiffness, an independent risk factor for cardiovascular events, and have a beneficial effect on central aortic BP, thus providing a possible explanation for the findings of ASCOT-BPLA and confirming that ACE inhibitors are an appropriate first choice for patients with hypertension.

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Effects of Antihypertensive Therapy on Glucose and Insulin Metabolism and on Left Ventricular Mass

Abstract: In obese, hypertensive individuals, adequate and similar blood pressure control was achieved with perindopril and atenolol. However, perindopril but not atenolol was associated with a more favorable GIM profile and led to a significant regression of LVM.

Cited by 30 publications

References 50 publications

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Effect of Metformin on Weight Gain During Antihypertensive Treatment With a -Blocker in Chinese Patients

ACE Inhibition in Hypertension

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