Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the saliva

Almeida, Patrícia Del Vigna de; Grégio, Ana Maria Trindade; Brancher, João Armando; Ignácio, Sérgio Aparecido; Machado, Maria Ângela Naval; Lima, Antônio Adilson Soares de; Azevedo, Luciana Reis

doi:10.1016/j.tripleo.2007.11.008

Cited by 56 publications

(46 citation statements)

References 28 publications

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“…Benzodiazepines decrease the salivary flow rate through the benzodiazepine receptors in the salivary glands and by indirect action on the salivary glands through the central benzodiazepine receptors (27). In this study, we observed an increased risk of dry mouth in HD patients taking benzodiazepines.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with xerostomia in haemodialysis patients

Lopez-Pintor¹,

López-Pintor²,

Casañas³

et al. 2017

Med Oral

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BackgroundTo determine the prevalence of xerostomia and hyposalivation in Haemodialysis (HD) patients, to clarify risk factors, assess patient´s quality of life, and to establish a possible correlation among interdialytic weight gain (IDWG) and xerostomia.Material and MethodsThis study was performed on a group of 50 HD patients. Data were collected using a questionnaire containing demographic and clinical variables, a visual analogue scale (VAS) for xerostomia, IDWG, and an oral health impact profile questionnaire (OHIP-14). Unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected.ResultsA total of 28 HD patients (56%) suffered xerostomia. Dry mouth was associated with hypertension (OR, 5.24; 95% CI, 1.11-24.89) and benzodiazepine consumption (OR, 5.96; 95% CI, 1.05-33.99). The mean xerostomia VAS and OHIP-14 scores were 31.74±14.88 and 24.38±11.98, respectively. No significant correlation was observed between IDWG% and VAS and OHIP total score. Nonetheless, a positive correlation between VAS level of thirst and IDWG% was found (r=0.48 p=0.0001). UWS and SWS means (determined in 30 patients) were 0.16±0.17 and 1.12±0.64, respectively. Decreased values of UWS and SWS were reported in 53.33% and 36.66% of HD patients.ConclusionsXerostomia in HD has a multifactorial aetiology due to accumulative risks as advanced age, systemic disorders, drugs, fluid intake restriction, and salivary parenchymal fibrosis and atrophy. Therefore, it is important to detect possible xerostomia risk factors to treat correctly dry mouth in HD patients and avoid systemic complications. Key words:Haemodialysis patients, xerostomia, salivary flow rate, hyposalivation, interdialytic weight gain, oral health-related quality of life.

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Section: Discussionmentioning

confidence: 99%

Risk factors associated with xerostomia in haemodialysis patients

Lopez-Pintor¹,

López-Pintor²,

Casañas³

et al. 2017

Med Oral

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“…Therefore, sympathetic stimulation predominates, which leads to more viscous saliva production. 35 Furthermore, because these medications act on the central nervous system, they can cause alterations in saliva by means of indirect actions on the salivary glands. Antipsychotics [36][37][38] , antihistamines, 39 drugs for overactive bladder, 40,41 and anticholinergic bronchodilators 42 also show anticholinergic activity, causing salivary hypofunction.…”

Section: Drugsmentioning

confidence: 99%

“…Xerostomia may occur as an indirect action of these drugs on the central nervous system, through mechanisms that are difficult to identify and, probably, by means of the serotonin action on the 5HT receptors present in the peripheral microcirculation. 35 Xerostomia has been related as a side effect of different classes of drugs for antihypertensive therapies, which cause salivary dysfunction in distinct ways. 48,49 Diuretics cause an overall decrease in intravascular and extracellular fluid volume.…”

Section: Drugsmentioning

confidence: 99%

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Salivary hypofunction: An update on aetiology, diagnosis and therapeutics

Saleh

Figueiredo

Cherubini

et al. 2015

Archives of Oral Biology

195

166

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“…Valproic acid has been linked to gingival overgrowth, apart from phenytoin (5), which increase plaque retentive areas thereby enhancing susceptibility for dental caries and periodontal disease (6). Benzodiazepines have been shown to cause hyposalivation and xerostomia (7) with reduction in stimulated salivary flow rate (8) thereby leading to increased incidence to dental caries.…”

Section: Discussionmentioning

confidence: 99%

A case report on dental management of a toddler with Pachygyria

et al. 2017

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Children with special health care needs receive less oral care than the normal population, inspite of the high level of dental diseases among them. They are at an increased risk for oral diseases throughout their lifetime. This paper reports a case of a toddler with congenital unusual thick convolutions of the cortex resulting in a condition called pachygyria. Intra oral examination showed multiple abscesses with poor oral hygiene. As the patient was lacking cooperative ability, treatment of full mouth rehabilitation as needed. The parents were advised for regular dental check-ups and informed about maintenance of good oral hygiene. This case report demonstrates the importance of oral hygiene maintenance of special children and also about their short and long term dental treatment protocol for maintaining good oral health. Key words:Pachygyria, general anaesthesia, special child, health care needs, preventive measures.

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Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the saliva

Cited by 56 publications

References 28 publications

Risk factors associated with xerostomia in haemodialysis patients

Risk factors associated with xerostomia in haemodialysis patients

Salivary hypofunction: An update on aetiology, diagnosis and therapeutics

A case report on dental management of a toddler with Pachygyria

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