Salivary hypofunction: An update on aetiology, diagnosis and therapeutics

Saleh, Jamil; Figueiredo, Maria Antonia Zancanaro de; Cherubini, Karen; Salum, Fernanda Gonçalves

doi:10.1016/j.archoralbio.2014.10.004

Cited by 193 publications

(252 citation statements)

References 185 publications

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“…3 Many factors have been associated with xerostomia. The most common causes are: 4,5,6,7,8,9 a. Medications (more than 400 drugs are associated with xerostomia as a side effect); b.…”

Section: Introductionmentioning

confidence: 99%

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

Niklander¹,

et al. 2017

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“…3 Many factors have been associated with xerostomia. The most common causes are: 4,5,6,7,8,9 a. Medications (more than 400 drugs are associated with xerostomia as a side effect); b.…”

Section: Introductionmentioning

confidence: 99%

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

Niklander¹,

et al. 2017

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“…Normally, the 3 major and numerous minor salivary glands work to produce continuous saliva secretion essential for the biological and functional health of the oral mucosa (reviewed in Grundmann et al 2009). However, in patients treated for head and neck cancer or those developing Sjögren's syndrome, decreased saliva secretion results in a permanent condition known as xerostomia, which is associated with numerous adverse consequences (Saleh et al 2015). Although the causes leading to xerostomia are diverse, the decrease in saliva production is due to a dramatic loss of functional secretory acinar cells (reviewed in Grundmann et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Salivary Glands

2015

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Understanding the intrinsic potential for renewal and regeneration within a tissue is critical for the rational design of reparative strategies. Maintenance of the salivary glands is widely thought to depend on the differentiation of stem cells. However, there is also new evidence that homeostasis of the salivary glands, like that of the liver and pancreas, relies on self-renewal of differentiated cells rather than a stem cell pool. Here, we review the evidence for both modes of turnover and consider the implications for the process of regeneration. We propose that the view of salivary glands as postmitotic and dependent on stem cells for renewal be revised to reflect the proliferative activity of acinar cells and their role in salivary gland homeostasis.

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“…The importance of salivary flow in maintaining oral health is related to its protective properties: lubrication, digestion, antimicrobial action, bacterial agglutination, salivary pellicle formation, taste, water balance, cleaning, buffering and remineralizing action [1,2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chewing Gum Containing CPP-ACP on Salivary Flow and Buffer Capacity: An in vivo Study

Pereira

Maciel

Monteiro

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate salivary flow and buffer capacity by means of mechanical and chemical-mechanical stimuli, through the use of chewing gums. Material and Methods: The study was a cross-sectional study with 12 volunteers, divided into three groups, in three phases: Group A: paraffin gum; Group B: Chewing gum without sucrose, flavored (Trident ® ); Group C: Flavored chewing gum, without sucrose and amorphous calcium casein-phosphate phosphopeptide (Trident Total ® ). The stimulated total saliva was collected after 5 minutes of mastication of one of the products and the volume was expressed in mL / min. The same sample was submitted to pH measurement with the use of a digital potentiometer, where the results were classified in normal buffer capacity (final pH between 5.0 and 7.0) or low (final pH <4.0). The results were evaluated regarding the normality of the sample distribution (Shapiro-Wilk test), Analysis of Variance (ANOVA) and Tukey's test. Results: Chewing gums increased the salivary flow of the volunteers, when compared to the control group (paraffin) (1.53 mL / min), differing statistically from the group, although there was no difference between Trident ® (2.09 mL / Min) and Trident Total ® (2.06mL / min). Regarding the buffer capacity, the values obtained were 6.94 (paraffin), 6.99 (Trident ® ) and 6.93 (Trident Total ® ), with no difference between groups (p = 0.713). Conclusion: It was concluded that chewing gums, with and without CPP-ACP, increased the salivary flow in relation to the control group. In relation to buffer capacity the values obtained for chewing gums with and without CPP-ACP, are shown to be within the normal range.

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Salivary hypofunction: An update on aetiology, diagnosis and therapeutics

Cited by 193 publications

References 185 publications

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

Salivary Glands

Effect of Chewing Gum Containing CPP-ACP on Salivary Flow and Buffer Capacity: An in vivo Study

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