Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders

Zhang, Xin; Zou, Qianhui; Zhao, Beita; Zhang, Jingwen; Zhao, Wenting; Li, Yitong; Liu, Ruihai; Liu, Xuebo; Liu, Zhigang

doi:10.1016/j.redox.2020.101535

Cited by 90 publications

(68 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Implicit in the present findings is that the microbiome shaped by IF and IF Ctrl changed dynamically during the fasting-refeeding cycles and responded very quickly to the dietary changes. Recently, several studies reported the mediating effect of the gut microbiota in the health-promoting effects of IF, such as enrichment of anti-inflammatory related microorganisms, upregulation of short-chain fatty acid production, enhancement of antioxidant microbial metabolic pathways, and increase in ketogenesis in the liver during fasting [ 23 , 41 , 42 ]. However, the above studies did not report the changes in the microbiota during fasting and refeeding periods and did not specify when the samples were collected.…”

Section: Discussionmentioning

confidence: 99%

The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice

et al. 2021

View full text Add to dashboard Cite

Background Calorie restriction (CR) and intermittent fasting (IF) can promote metabolic health through a process that is partially mediated by gut microbiota modulation. To compare the effects of CR and IF with different dietary structures on metabolic health and the gut microbiota, we performed an experiment in which mice were subjected to a CR or IF regimen and an additional IF control (IFCtrl) group whose total energy intake was not different from that of the CR group was included. Each regimen was included for normal chow and high-fat diet. Results We showed that in normal-chow mice, the IFCtrl regimen had similar positive effects on glucose and lipid metabolism as the CR regimen, but the IF regimen showed almost no influence compared to the outcomes observed in the ad libitum group. IF also resulted in improvements, but the effects were less marked than those associate with CR and IFCtrl when the mice were fed a high-fat diet. Moreover, CR created a stable and unique gut microbial community, while the gut microbiota shaped by IF exhibited dynamic changes in fasting-refeeding cycles. At the end of each cycle, the gut microbiota of the IFCtrl mice was similar to that of the CR mice, and the gut microbiota of the IF mice was similar to that of the ad libitum group. When the abundance of Lactobacillus murinus OTU2 was high, the corresponding metabolic phenotype was improved regardless of eating pattern and dietary structure, which might be one of the key bacterial groups in the gut microbiota that is positively correlated with metabolic amelioration. Conclusion There are interactions among the amount of food intake, the diet structure, and the fasting time on metabolic health. The structure and composition of gut microbiota modified by dietary regimens might contribute to the beneficial effects on the host metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Psychiatric disorders are closely associated with the activation of immune/inflammatory response, which is manifested by the activation of macrophages (such as microglia) in CNS, inducing the release of multiple inflammatory cytokines and creating a “waterfall” effect ( 32 ). The above cascade of responses has been widely reported in DSS-induced UC mice ( 33 , 34 ). In this study, the activation of microglial cells and over-expression of multiple inflammatory cytokines were found in the DSS group, while the SJE treatment alleviated these changes ( Figure 2 ).…”

Section: Discussionmentioning

confidence: 80%

Saccharina japonica Ethanol Extract Ameliorates Depression/Anxiety-Like Behavior by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Dextran Sodium Sulfate Induced Ulcerative Colitis Mice

Dong

Lin

et al. 2021

Front. Nutr.

View full text Add to dashboard Cite

Saccharina japonica is a common marine vegetable in East Asian markets and has a variety of health benefits. This study was focused on the anti-depressant/anxiety effects of Saccharina japonica ethanol extract (SJE) on dextran sodium sulfate (DSS)-induced mice and its potential mechanism in their brain. Male C57BL/6 mice were treated with mesalazine and various doses of SJE (1, 2, and 4 g/kg body weight) for 2 weeks, followed by DSS treatment at the second week. The DSS-induced mice showed depression/anxiety-like behavior, which included shorter path length in the open field test and longer immobility time in the tail suspension test. L-SJE alleviated the depression-like behaviors. In the DSS-induced mice, reduced synaptic plasticity activated microglia, increased proinflammatory cytokines, decreased anti-inflammatory cytokine, and increased expression levels of Toll-like receptors-4, nuclear factor kappa-B, NOD-like receptors 3, apoptosis-associated speck-like protein, and Caspase-1 were observed, most of which were alleviated by SJE treatment. Furthermore, all the SJE groups could significantly enhance superoxide dismutase activity, while the L-SJE treatment decreased the contents of malondialdehyde, and the H-SJE treatment inhibited apoptosis. All these results showed that the SJE might serve as a nutritional agent for protecting the brain in ulcerative colitis mice.

show abstract

“…According to the literature, during chronic intestinal inflammation, serum IL-6 levels were up-regulated (Zonis et al, 2015 ). Recently, new research has shown that IBA-1 expressions were significantly increased in the cortex and hippocampus of the DSS-treated mice for 36 days (Zhang et al, 2020 ), reflects the neuroinflammation status. Additionally, pro-inflammatory cytokines, as well as levels of GFAP in the brain were up-regulated after DSS treatment.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

Han

Ding

Cheng

et al. 2020

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The importance of hypoxia in the pathophysiology of inflammatory bowel disease (IBD) is increasingly being realized; also, hypoxia seems to be an important accelerator of brain inflammation, as has been reported by our group and others. IBD is a chronic intestinal disorder that leads to the development of inflammation, which is related to brain dysfunction. However, no studies have reported whether hypoxia is associated with IBD-induced neuroinflammation. Therefore, the objective of the present study was to determine whether hypoxia augments cerebral inflammation in a DSS-induced colitis mouse model. The mouse model was developed using 3% DSS for five days combined with exposure to hypoxic conditions (6,000 m) for two days. Mice were randomly divided into four groups: control group, DSS group, hypoxia group, and DSS plus hypoxia group. The results demonstrated that DSS combined with hypoxia resulted in up-regulation of colonic and plasmatic proinflammatory cytokines. Meanwhile, DSS plus hypoxia increased expression of Iba1, which is a marker of activated microglia, accompanied by increased expression of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in the brain. Moreover, the expression of tight junction proteins, such as zonula occludens-1 (ZO-1), occludin, and claudin-5, was markedly downregulated. The current study provides new insight into how hypoxia exposure induces excessive inflammatory responses andpathophysiological consequences in the brain in a DSS-induced colitis model.

show abstract

Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders

Cited by 90 publications

References 63 publications

The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice

The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice

Saccharina japonica Ethanol Extract Ameliorates Depression/Anxiety-Like Behavior by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Dextran Sodium Sulfate Induced Ulcerative Colitis Mice

Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

Contact Info

Product

Resources

About