Effects of allopurinol, ibuprofen and cyclosporin A on local microcirculatory disturbances due to burn injuries

A Review of the Local Pathophysiologic Bases of Burn Wound Progression

“…In their study, using a rat full-thickness comb burn model, pretreatment with cyclosporine A (believed to modulate neutrophil accumulation during acute inflammation) resulted in increased perfusion of the interspace panniculus carnosus muscle and a reduction in the interspace water content, an indicator of edema. 41 This study demonstrated that neutrophils are an important cause of ischemia in the zone of stasis that is associated with progression to tissue necrosis.…”

“…33,38,39,41,[43][44][45] Recent evidence from a clinical study points to the complement product C3d and C-reactive protein as having roles in skin leukocyte sequestration after burn injury. 46 A number of studies explore the utility of various inhibitors of postburn inflammatory cell infiltration ( Table 2).…”

Role of antioxidants in the treatment of burn lesions

“…19 In burn patients alterations in the antioxidant micronutrient status and in the endogenous antioxidant defence against the deleterious effects of free radicals seem crucial, as pointed out by recent studies. 20 Data reported by Cetinkale et al 21 demonstrated that in addition to loss of plasma antioxidants like vitamin E and sulphydryl groups in patients with burns, vitamin C diminished early post-burn. Recently, Traber et al 22 suggested that a-tocopherol should be administered to burn patients to prevent vitamin E depletion and to protect against oxidative stress from burn injury.…”

Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing.

“…30) Oxygen radicals involve in the progression of tissue injury. 31,32) XO and oxygen free radicals were responsible for increased permeability in the pathogenesis of burn edema. 34,35) Anti-oxidant scavenging capacity was also significantly reduced in the local burn wound.…”