Role of antioxidants in the treatment of burn lesions

Sahib, Ahmed Salih; Al-Jawad, Faruk H.; Al-Kaisy, A A

doi:10.1016/j.burns.2009.06.126

Cited by 23 publications

(39 citation statements)

References 29 publications

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“…A major source of oxidative stress in burn trauma is the xanthine oxidase enzyme, which produces superoxide anions and hydrogen peroxide. On the other hand, activated neutrophils also play an important role in producing superoxide anions [25]. Treatment with saffron decreased the neutrophil counts in the present study and resulted in reduced free radicals and reactive oxygen species in the burn environment.…”

Section: Discussionsupporting

confidence: 46%

Effectiveness of a Crocus sativus Extract on Burn Wounds in Rats

Alemzadeh

Oryan

2018

Planta Med

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is a spice with various pharmacological properties. Crocin, picrocrocin, and safranal are the main compositions of saffron that have recently been considered in the therapy of many diseases. High-performance liquid chromatography analysis revealed presence of these compounds in our saffron extract. This study was carried out to evaluate the effect of saffron on burn wound healing at an model. Saffron was topically applied on burn wounds in rats; the percentage of wound closure, wound contraction, and the levels of main cytokines and growth factors were measured. The saffron extract was also applied to evaluate the proliferation and migration of human dermal fibroblast (HDF) cells using scratch assay and resulted in active proliferation and migration of the HDF cells in a dose-dependent manner. A clear enhanced healing was observed in the saffron-treated wounds compared to the silver sulfadiazine and negative control groups. Decreased expression of interleukin-1 and transforming growth factor-1 (TGF-1) during the inflammatory phase demonstrated the role of saffron in promoting wound healing. In addition, enhanced TGF-1 expression during the proliferative phase and basic fibroblast growth factor during the remodeling phase represented regenerative and anti-scarring role of saffron, respectively. Our histological and biochemical findings also confirmed that saffron significantly stimulated burn wound healing by modulating healing phases. Therefore, saffron can be an optimal option in promoting skin repair and regeneration. Application of this herbal medicinal drug should be encouraged because of its availability and negligible side effects.

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Section: Discussionsupporting

confidence: 46%

Effectiveness of a Crocus sativus Extract on Burn Wounds in Rats

Alemzadeh

Oryan

2018

Planta Med

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“…[19] H 2 O 2 can be reduced to water by GPxs or PRX. [20] H 2 O 2 may react directly with specific thiols, yielding sulfenic acids. [21] Sulfenic acids can react with other thiols, yielding disulfides.…”

Section: Reversible Post-translational Redox Modifications Of Protmentioning

confidence: 99%

“…Angiogenesis, the formation of new blood vessels, is also induced by hypoxia and promoted in wound healing (602). Trx1 has been analyzed in burn injuries, demonstrating, among others, a potential function in wound healing (2), which is also seen for N-acetylcysteine (20).…”

Section: Urinary Tract and Reproductive Systemsmentioning

confidence: 99%

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Hanschmann

Godoy

Berndt

et al. 2013

Antioxidants & Redox Signaling

581

532

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Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been characterized as electron donors, guards of the intracellular redox state, and "antioxidants". Today, these redox catalysts are increasingly recognized for their specific role in redox signaling. The number of publications published on the functions of these proteins continues to increase exponentially. The field is experiencing an exciting transformation, from looking at a general redox homeostasis and the pathological oxidative stress model to realizing redox changes as a part of localized, rapid, specific, and reversible redox-regulated signaling events. This review summarizes the almost 50 years of research on these proteins, focusing primarily on data from vertebrates and mammals. The role of Trx fold proteins in redox signaling is discussed by looking at reaction mechanisms, reversible oxidative post-translational modifications of proteins, and characterized interaction partners. On the basis of this analysis, the specific regulatory functions are exemplified for the cellular processes of apoptosis, proliferation, and iron metabolism. The importance of Trxs, Grxs, and Prxs for human health is addressed in the second part of this review, that is, their potential impact and functions in different cell types, tissues, and various pathological conditions.

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“…According to published data, NBT test monitoring plays an important prognostic role: initial rise of NBT test followed by its gradual decrease was associated with better survival of experimental rats, while continuous growth of NBT test was associated with poor outcome. Moreover, hyperergia of neutrophils after TI promotes endothelial dysfunction and multiple organ failure due to the attack of ROS and lysosome-derived enzymes [13]. Serum level of IL-1β was elevated on day 7 (7.76±1.02 vs. 0.23±0.11 pg/ml in intact animals; p<0.01) and on day 14 (1.57±0.27 pg/ml; p<0.01), and returned to basal level by day 28 (0.31±0.08 pg/ml; p>0.05).…”

Section: Resultsmentioning

confidence: 99%

Effect of Local Application of Epidermal Growth Factor on Innate Immunity and Cell Composition of Destruction Focus in Experimental Thermal Injury

2014

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The effect of recombinant human epidermal growth factor (rhEGF) on innate immunity and cellular composition of the destruction focus in the third-degree (IIIA) burn (skin contact with an object heated to 100°C; 4% body surface) was studied in experiments on outbred albino rats. On days 7-28 after burn, blood count of phagocytes and their absorbing capacity and oxygen-dependent metabolism increased, which correlated with the increase in serum IL-1β level and neutrophil count in the destruction focus. Local application of rhEGF led to earlier (on day 14) normalization of the count and functional activity of blood phagocytes and decrease in serum IL-1β level and accelerated neutrophil and lymphocyte replacement with fibroblasts in the focus of injury.

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Role of antioxidants in the treatment of burn lesions

Cited by 23 publications

References 29 publications

Effectiveness of a Crocus sativus Extract on Burn Wounds in Rats

Effectiveness of a Crocus sativus Extract on Burn Wounds in Rats

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

Effect of Local Application of Epidermal Growth Factor on Innate Immunity and Cell Composition of Destruction Focus in Experimental Thermal Injury

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