1. The effects of some drugs acting at the central-type benzodiazepines receptors on blood glucose levels in mice were studied. 2. Clonazepam, injected intraperitoneally in doses of 0.625-5 mg, produced a dose-dependent increase in blood glucose 30 min after administration. 3. The hyperglycaemic effect of clonazepam (2.5 mg/kg, i.p.) was dose-dependently reduced by Ro 15-1788 (10-40 mg/kg, i.v.), a benzodiazepine antagonist. 4. Ro 5-3663, a GABA antagonist which may act at the picrotoxinin site, produced a significant increase in blood glucose (5 or 10 mg/kg, i.p.); however, when given together with clonazepam (2.5 mg/kg, i.p.) attenuation of the hyperglycaemic effect was observed. 5. Pk 8165, a partial agonist, lacked an effect on blood glucose over the dose range of 5-20 mg/kg, i.p. but caused a slight increase in blood glucose in a dose of 40 mg/kg, i.p.
OBJECTIVE: The current study was designed to determine the hepatoprotective effect of well-known drugs. Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4. The antioxidant effects of b-blockers, especially carvedilol, have been described by several investigators. However, for metoprolol, the effect is a bit query as there is only one in-vitro study showing a little hepatoprotective effect. Thus, it is worthy to re-study the hepatoprotective effect of metoprolol. AIM: To explore the possible hepatoprotective effect of Nitroglycerin, N-acetyl cysteine and Metoprolol TartrateMATERIAL AND METHODS: The normal serum values of ALP, AST, ALT, TSB and TSP were determined in 35 healthy rabbits allocated to 5 groups before CCL4 induction and at three occasions 24, 72, 120 hrs after induction by CCL4 and treatment with the tested drugs: Nitroglycerin, N-acetyl cysteine and Metoprolol for five successive days.RESULTS: Showed significant decrease in serum levels of ALP, AST, ALT and TSB with a significant increase in TSP level of all the tested drugs measured at 120 hrs compared with the control and their levels measured at 24, 72 hrs.CONCLUSION: All the tested drugs proved in having a hepatoprotective effect when they are given orally to animals. The histopathological sections of the liver tissue supported the real effect of these drugs in the management of ALI.
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