Effects of all-trans retinoic acid on melanogenesis in pigmented skin equivalents and monolayer culture of melanocytes

Yoshimura, K.; Tsukamoto, Katsuhiko; Okazaki, Mutsumi; Virador, Victoria; Lei, Tiechi; Suzuki, Yasutoshi; Uchida, Gentaro; Kitano, Yukie; Harii, Kiyonori

doi:10.1016/s0923-1811(01)00116-5

Cited by 76 publications

(61 citation statements)

References 36 publications

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“…31) Yoshimura et al 32) also reported that ATRA enhanced melanin production in both murine melanocyte cell lines (melan-a) and human melanocytes at the same concentration. However, the present study indicates that ATRA significantly decreased melanogenesis in a concentration range of 1-20 mM.…”

Section: Discussionmentioning

confidence: 97%

Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells

Sato

Morita

Ichikawa

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 97%

Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells

Sato

Morita

Ichikawa

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…They found that tretinoin does not exert any suppressing effect on melanogenesis in pigmented skin equivalents. There were no direct inhibitory effects on interactions between melanocytes, keratinocytes and fibroblasts or on paracrine actions related to melanin production (10). The effect of tretinoin on melanogenesis and its mechanism of action on the treatment of hyperpigmented lesions are not yet entirely elucidated.…”

Section: Discussionmentioning

confidence: 98%

“…Yoshimura et al (10) conducted a study to investigate about this issue. They found that tretinoin does not exert any suppressing effect on melanogenesis in pigmented skin equivalents.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Therapeutic Effects of Topical Mometasone Furoate 0.1% Plus Tretinoin 0.05% and Topical Mometasone Furoate 0.1% Plus Eucerin in the Treatment of Vitiligo

Behrangi

Rasi

Jannati³

et al. 2015

J Skin Stem Cell

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Background: Long-term treatments with topical corticosteroids, for diseases like vitiligo, are associated with the risk of skin atrophy. Objectives: Recent studies suggest that administration of topical tretinoin, with a corticosteroid, diminishes skin atrophy without impacting the steroid's anti-inflammatory effects. Patients and Methods: A placebo-controlled, paired-comparison, left-right study was conducted for a period of 6 months on topical tretinoin 0.05% and mometasone furoate 0.1 % with topical mometasone furoate 0.1% and eucerin in 16 patients, diagnosed with generalized vitiligo. Clinical responses and side effects were assessed after 3 and 6 months. Results: After 6 months treatment with topical mometasone furoate 0.1 % and tretinoin 0.05%, an excellent response was found in two (12.50%) patients, a moderate response in 13 (81.25%) and mild response in one (6.25%) patient. Two patients (12.5%) showed side effects. After 6 months treatment with topical mometasone furoate 0.1% and eucerin, an excellent response was observed in one (6.25%) patient, a moderate response in eight (50%), mild response in six (37.5 %), and no response in one (6.25%) of the patients. Eight (50%) patients had side effects. After 6 months treatment, the topical tretinoin 0.05% and mometasone furoate 0.1% had more efficacy than mometasone furoate 0.1% and eucerin (P = 0.02). Conclusions: Combination therapy with tretinoin plus topical corticosteroids is safe and effective and provides an alternative in the treatment of patients with vitiligo.

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“…One such agent is all-trans retinoic acid (atRA), a vitamin A derivative that lightens skins by accelerating epidermal turnover and melanin granule discharge [30]. While atRA is efficacious in treating hyperpigmentation, its poor stability in heat, air and light has limited its use.…”

Section: Color Correctionmentioning

confidence: 99%

Nanotechnology, Inflammation and the Skin Barrier: Innovative Approaches for Skin Health and Cosmesis

2015

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Dermatologic physiology and aesthetics are profoundly connected. Inflammatory stimuli abound in the environment, and have the potential to impact both the physiology and aesthetics of the integument. Inflammation results in a compromised epidermal barrier, impaired moisture retention, erythema, scale and pigment alteration. The advent of nanotechnology has introduced a variety of new approaches to preserving skin cosmesis in the face of inflammation. In this article, we review the architecture and physiology of the epidermal barrier, describe the pathological and aesthetic effects of inflammation, and report recent advances in the development of nanomaterials to offset the aesthetic impact of inflammation.

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Effects of all-trans retinoic acid on melanogenesis in pigmented skin equivalents and monolayer culture of melanocytes

Cited by 76 publications

References 36 publications

Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells

Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells

Comparative Study of the Therapeutic Effects of Topical Mometasone Furoate 0.1% Plus Tretinoin 0.05% and Topical Mometasone Furoate 0.1% Plus Eucerin in the Treatment of Vitiligo

Nanotechnology, Inflammation and the Skin Barrier: Innovative Approaches for Skin Health and Cosmesis

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