1993
DOI: 10.1213/00000539-199305000-00023
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Effects of Alfentanil on the Hemodynamic and Catecholamine Response to Tracheal Intubation

Abstract: A randomized, placebo-controlled study was conducted in 60 ASA Class I, II, and III patients to determine the dose response of alfentanil in moderating the cardiovascular and catecholamine response to tracheal intubation (INT). Patients were randomly allocated into one of four groups to receive either 15 micrograms/kg alfentanil (A15), 30 micrograms/kg alfentanil (A30), 45 micrograms/kg alfentanil (A45), or normal saline (control), given intravenously (i.v.) before induction of anesthesia. One minute after adm… Show more

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Cited by 98 publications
(43 citation statements)
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“…The combination of alfentanil 30 mg/kg with thiopentone 4 mg/kg and succinylcholine 1.5 mg/kg provided complete attenuation of the haemodynamic response to intubation 118,119 [II]. Increasing the dose of Alfentanil to 45 or 60 mg/kg resulted in transient but significant decreases in the heart rate and the mean arterial pressure.…”
Section: Alfentanilmentioning
confidence: 99%
“…The combination of alfentanil 30 mg/kg with thiopentone 4 mg/kg and succinylcholine 1.5 mg/kg provided complete attenuation of the haemodynamic response to intubation 118,119 [II]. Increasing the dose of Alfentanil to 45 or 60 mg/kg resulted in transient but significant decreases in the heart rate and the mean arterial pressure.…”
Section: Alfentanilmentioning
confidence: 99%
“…These included epinhalational anaesthesia, deep intravenous general anaesthesia, topical anaesthesia with lignocaine, drugs like anti hypertensives, beta adrenoreceptor antagonists (propranolol, metoprolol, esmolol, 2 labetolol), Gabapentine, 3 peripheral vasodilators, intravenous lignocainelignocaine aerosol 4,5 Angiotension converting enzyme blockers,Magnesiumsulphate, 6 alpha2 agonist ( Dexmedetomidine, 7 Clonidine 8 ), Droperial, intravenous Ketorolac, Nitroglycerine ointment, Calcium channel blocker, Buprenorphine, Fentanyl [9][10][11][12][13] and Alfentanil. [14][15][16] During laryngoscopy and intubation, fentanyl, µ receptor agonist is a natural choice to attenuate pressor response. 17 Low dose fentanyl decreases the circulatory response to tracheal intubation, reduces the dose of thiopentone, has rapid onset of action, extremely lipid soluble, provides cardiovascular stability throughout the operative period, blocks sympathetic stress response to surgical stimulation, rapid and potent analgesic, anxiolytic and sedative and decreases the concentration of inhaled agent requirement.…”
Section: Introductionmentioning
confidence: 99%
“…However, no data exist regarding the effects of additional propofol doses given before intubation on hemodynamic changes and BIS in the postintubation period. Recently, noninvasive cardiac index (CI) monitors have become available for continuous measurement of beat-to-beat stroke volume (SV) with impedance cardiography [12,13].…”
Section: Introductionmentioning
confidence: 99%