Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study

Miyazaki, M; Kikuchi, Yuji; Sudo, Takashi; Sawano, Yukari; Shimada, Hitoshi

doi:10.1016/j.jclinane.2007.11.006

Cited by 11 publications

(5 citation statements)

References 17 publications

(26 reference statements)

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“…Suspension laryngoscopy under general anaesthesia can cause marked increases in heart rate and blood pressure. The ability of adjuvant drugs to limit these changes has been assessed, including selective β1‐adrenergic antagonists‐blockers [1], calcium channel blockers [2], local anaesthetics and glucocorticoids [3]. These adjuvant drugs therefore reduce the utility of haemodynamic variables to indicate whether patients are adequately anaesthetised [4, 5].…”

mentioning

confidence: 99%

A randomised controlled trial of dexmedetomidine for suspension laryngoscopy

Liu¹,

Zhang²,

She³

et al. 2012

Anaesthesia

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mentioning

confidence: 99%

A randomised controlled trial of dexmedetomidine for suspension laryngoscopy

Liu¹,

Zhang²,

She³

et al. 2012

Anaesthesia

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“…A total of 12 trials 15,20-30 were retrieved for in-depth consideration for inclusion in the review. However, five of these trials were subsequently excluded: three because of a missing placebo group 22,27,28 , one because of a duplicate publication 29 and one because of missing minimum values for variables after administration of landiolol 26 (for this study, we contacted the corresponding author by email to try to clarify the data). This left seven eligible trials with a total of 325 patients.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-two trials were excluded because of duplicate references and 51 were excluded because they were non-clinical trials, on-going studies or abstracts that were subsequently published as full articles. A total of 12 trials 15,[20][21][22][23][24][25][26][27][28][29][30] were retrieved for in-depth consideration for inclusion in the review. However, five of these trials were subsequently excluded: three because of a missing placebo group 22,27,28 , one because of a duplicate publication 29 and one because of missing minimum values for variables after administration of landiolol 26 (for this study, we contacted the corresponding author by email to try to clarify the data).…”

Section: Resultsmentioning

confidence: 99%

The Efficacy of Landiolol for Suppressing the Hyperdynamic Response following Laryngoscopy and Tracheal Intubation: A Systematic Review

Inoue

Tanaka

Kawaguchi

et al. 2009

Anaesth Intensive Care

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Landiolol is a recently developed, selective short-acting ß1-antagonist. The aim of the study was to evaluate the efficacy of landiolol for suppressing haemodynamic changes induced by laryngoscopy and tracheal intubation (LTI) in Japanese patients. A comprehensive search was undertaken to identify all randomised comparisons of landiolol with placebo that examined effects on haemodynamic responses following LTI. MEDLINE, Cochrane CENTRAL, EMBASE and the Japanese Central Review of Medicine were searched from their date of inception to February 2009. Trials were included in the review if heart rate, systolic blood pressure or mean blood pressure was recorded at three different stages: pre-induction, just before intubation and in the post-intubation period. Weighted mean differences and 95% confidence intervals (CI) were calculated for changes in haemodynamic variables between treatment and placebo groups. Seven randomised controlled trials involving 325 patients were included in the study. Of these, five trials that used the same continuous infusion regimen for landiolol (0.125 mg/kg/minute for one minute followed by 0.04 mg/kg/minute) showed efficacy in attenuation of heart rate and blood pressure following LTI (heart rate weighted mean difference:-21.18 bpm, 95% CI-18.59 to-14.20; systolic blood pressure weighted mean difference:-23.03 mmHg, 95% CI-43.59 to-2.47; mean blood pressure weighted mean difference:-16.26 mmHg, 95% CI-23.96 to-8.55). The other two studies used bolus administration of landiolol (0.1 to 0.3 mg/kg), but it was difficult to evaluate the efficacy because of the limited amount of data. Landiolol administration at 0.125 mg/kg/minute for one minute followed by 0.04 mg/kg/minute effectively suppresses the increases in heart rate and blood pressure following LTI. For a bolus regimen of landiolol, further studies are required to determine the efficacy and the optimal dose and timing for suppression of haemodynamic responses following LTI.

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“…Therefore, various studies have been published regarding to the prevention of abrupt haemodynamic changes following endotracheal intubation [2][3][4]11,[13][14][15] . To abate such condition, anaesthesiologists could apply several medications, such as beta-blockers, calcium channel blockers, lidocaine, propofol and opioids 4,11,[13][14][15][16][17] . Aside from diverse medications, different intubating skills and methods can reduce haemodynamic changes such as fiberoptic intubation 12,18 , optimal fentanyl dosage 4,9,19 and routes of drugs given 19 .…”

Section: Discussionmentioning

confidence: 99%

The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial

Teong

Huang

Sun

2020

Sci Rep

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Endotracheal intubation elicits huge spectrum of stress responses which are hazardous in high-risk patients. Numerous drugs and techniques have been applied to attenuate the stress responses. In this double-blind study, one hundred and forty-five patients over 20 years old, ASA physical status I and II, undergoing elective surgeries requiring general anaesthesia with endotracheal intubation were included. Patients were randomly divided into three groups which fentanyl 2 mcg/kg was given at either 1, 2, 3 minutes before intubation. All groups received midazolam 0.05 mg/kg, lidocaine 0.5 mg/ kg, propofol 2 mg/kg and rocuronium 1 mg/kg before intubation. Haemodynamic parameters were recorded for 10 minutes after induction. Two-level longitudinal hierarchical linear models were used for data interpretation and P < 0.05 was considered statistically significant. The study demonstrated significantly lower haemodynamic responses in the group who received fentanyl 2 minutes before intubation (p < 0.05). Confounding factors such as smoking, hypertension, diabetes mellitus and preoperative intravenous fluid supplement were analysed. In conclusion, fentanyl injection 2 minutes before intubation is recommended in order to obtain the most stable haemodynamic status.

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Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study

Cited by 11 publications

References 17 publications

A randomised controlled trial of dexmedetomidine for suspension laryngoscopy

A randomised controlled trial of dexmedetomidine for suspension laryngoscopy

The Efficacy of Landiolol for Suppressing the Hyperdynamic Response following Laryngoscopy and Tracheal Intubation: A Systematic Review

The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial

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