Effects of Alcohol Ingestion on Vestibular Function in Postural Control

Tianwu, H.; Watanabe, Yoshinori; Asai, Manabu; Shimizu, Katsutoshi; Takada, Shozo; Mizukoshi, K.

doi:10.3109/00016489509121886

Cited by 42 publications

(30 citation statements)

References 8 publications

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“…The presence of ethyl alcohol in the central nervous system (CNS) can interfere with the transmission of nerve impulses at the synapse (Mullikin-Kilpatrick and Treistman, 1994;Treistman et al, 1991). Alcohol intoxication impairs vestibular senses (Kubo et al, 1990;Tianwu et al, 1995), reduces the amplitude of mono-and poly-synaptic reflexes (Ashby et al, 1977), and prolongs the latency and reduces the amplitude of long latency muscle responses (Woollacott, 1983). Therefore, alcohol intoxication leads to deleterious effects on both the sensory and motor systems (Fuster et al, 1985) and is likely to have profound effects on body movement control while standing.…”

Section: Introductionmentioning

confidence: 99%

Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Modig

Fransson

Magnusson

et al. 2012

Alcohol

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Link to publication Citation for published version (APA): Modig, F., Fransson, P-A., Magnusson, M., & Patel, M. (2012). Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control. Alcohol, 46, 75-88. DOI: 10.1016/j.alcohol.2011 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractAlcohol-related falls are recognized as a major contributor to the occurrence of traumatic brain injury. The control of upright standing balance is complex and comprises contributions from several partly independent mechanisms like appropriate information from multiple sensory systems and correct feedback and feedforward movement control. Analysis of multisegmented body movement offers a rarely used option for detecting the fine motor problems associated with alcohol intoxication.The study aims were: 1) to investigate whether alcohol intoxication at 0.06% and 0.10% blood alcohol concentration (BAC) affected linear body movement under unperturbed and perturbed standing; and 2) to investigate whether alcohol affected the ability for sensorimotor adaptation.Body movements were recorded in 25 participants (13 women and 12 men, mean age 25.1 years) at five locations (ankle, knee, hip, shoulder and head) during quiet standing and during balance perturbations from pseudorandom pulses of calf muscle vibration over 200s with eyes closed or open. Tests were performed at 0.00%, 0.06% and 0.10% BAC.The study revealed several significant findings: 1). An alcohol dose-specific effect; 2). A direction-specific stability decrease from alcohol intoxication; 3). A movement pattern change related to the level of alcohol intoxication during unperturbed standing and perturbed standing; 4). A sensorimotor adaptation deterioration with increased alcohol intoxication; and 5). That vision provided a weaker contribution to postural control during alcohol intoxication.Hence, alcohol intoxication at 0.06% and 0.10% BAC causes a complex multifaceted deterioration of human postural control.

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Section: Introductionmentioning

confidence: 99%

Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Modig

Fransson

Magnusson

et al. 2012

Alcohol

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“…Consequences of smoking include, among others, respiratory and cardiovascular diseases, cancer, injuries, disabilities, and over 1.2 million deaths in the WHO European Region, annually 1,6,21,27,29) . Consequences of alcohol abuse include, among others, cirrhosis, cardiovascular diseases, cancer, gastrointestinal problems, neurocognitive deficits, bone loss, emotional challenges, depression, deteriorated postural control, injuries, job loss, sickness absence, and 1.8 million deaths worldwide 1,6,22,28,[30][31][32] . Note that manual workers have a higher prevalence of smoking than higher socio-economic classes [33][34][35] .…”

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confidence: 99%

Association of Physical Job Demands, Smoking and Alcohol Abuse with Subsequent Premature Mortality: A 9‐year Follow‐up Population‐based Study

Bourgkard

Wild

Massin

et al. 2008

Journal of Occupational Health

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, smoking, and alcohol abuse, with premature mortality before age 70 (PM-70) among the working or inactive population. The sample included 4,268 subjects aged 15 or more randomly selected in northeastern France. They completed a mailed questionnaire (birth date, sex, weight, height, job, PJD, smoking habit, alcohol abuse (Deta questionnaire)) in 1996 and were followed for mortality until 2004 (9 yr). PJD score was defined by the cumulative number of the following high job demands at work: hammer, vibrating platform, pneumatic tools, other vibrating hand tools, screwdriver, handling objects, awkward posture, tasks at heights, machine tools, pace, working on a production line, standing about and walking. The data were analyzed using the Poisson regression model. Those with PM-70 were 126 (3.81 per 1,000 personyears). The leading causes of death were cancers (46.4% in men, 57.1% in women), cardiovascular diseases (20.2% and 11.9%), suicide (9.5% and 7.1%), respiratory diseases (6.0% and 4.8%), and digestive diseases (2.4% and 4.8%). PJD≥3, smoker, and alcohol abuse had adjusted risk ratios of 1.71 (95% CI 1.02-2.88), 1.76 (1.08-2.88), and 2.07 (1. 31-3.26) respectively for all-cause mortality. Manual workers had a risk ratio of 1.84 (1.00-3.37) compared to the higher socio-economic classes. The men had a twofold higher mortality rate than the women; this difference became non-significant when controlling for job, PJD, smoker and alcohol abuse. For cancer mortality the factors PJD≥3, smoker, and alcohol abuse had adjusted risk ratios of 2

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“…Alcohol has been shown to significantly diminish the nystagmus evoked by both caloric irrigation and horizontal angular rotation (Berthoz et al, 1977;Bochenek and Ormerod, 1962;Chiang and Young, 2007;Post et al, 1994;Tianwu et al, 1995). Similarly, alcohol decreases dynamic visual acuity during vertical translations, though the gain of the translational VOR does not appear to be affected (Schmäl et al, 2000(Schmäl et al, , 2003.…”

Section: Introductionmentioning

confidence: 99%

“…The greatest deficits typically occur on tasks thought to rely on vestibular input, i.e. in which visual and proprioceptive cues are absent or misleading, such as standing with eyes closed on an unstable surface (Goebel et al, 1995;Ledin and Ödqvist, 1991;Tianwu et al, 1995;Woollacott, 1983). The clearest evidence of a direct effect of alcohol on the peripheral vestibular organs is the occurrence of positional alcohol nystagmus (PAN), in which alcohol is thought to change the specific gravity of the cupula, causing the semicircular canals to become sensitive to gravity and evoking nystagmus when the head is tilted laterally (Aschan and Bergstedt, 1975;Fetter et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…The gain and slow phase velocity of optokinetic nystagmus also tends to be decreased with alcohol (Baloh et al, 1979;Tianwu et al, 1995) and the ability to suppress the VOR during head motion is diminished (Barnes, 1984;Harder and Reker, 1995). One of the best-documented oculomotor effects of alcohol consumption is gaze-evoked nystagmus (GEN), resulting from a deficit in gaze-holding and the neural integrator (e.g.…”

Section: Introductionmentioning

confidence: 99%

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The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

Rosengren

Weber

Hegemann

et al. 2014

Clinical Neurophysiology

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OBJECTIVE: We investigated the effect of alcohol on the cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs). As alcohol produces gaze-evoked nystagmus (GEN), we also tested the effect of nystagmus independent of alcohol by recording oVEMPs during optokinetic stimulation (OKS). METHODS: The effect of alcohol was tested in 14 subjects over multiple rounds of alcohol consumption up to a maximum breath alcohol concentration (BrAC) of 1.5‰ (mean 0.97‰).The effect of OKS was tested in 11 subjects at 5, 10 and 15deg/sec. RESULTS: oVEMP amplitude decreased from baseline to the highest BrAC level by 27% (range 5-50%, P<0.001), but there was no significant effect on oVEMP latency or cVEMP amplitude or latency. There was a significant negative effect of OKS on oVEMP amplitude (16%, P=0.006). CONCLUSIONS: We found a selective effect of alcohol on oVEMP amplitude, but no effect on the cVEMP. Vertical nystagmus elicited by OKS reduced oVEMP amplitude. SIGNIFICANCE: Alcohol selectively affects oVEMP amplitude. Despite the effects of alcohol and nystagmus, both reflexes were reliably recorded in all subjects and conditions. An absent response in a patient affected by alcohol or nystagmus indicates a vestibular deficit.

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Effects of Alcohol Ingestion on Vestibular Function in Postural Control

Cited by 42 publications

References 8 publications

Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Association of Physical Job Demands, Smoking and Alcohol Abuse with Subsequent Premature Mortality: A 9‐year Follow‐up Population‐based Study

The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

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