Effects of age and physiologic variables on right ventricular filling dynamics in normal subjects

Klein, Allan L.; Leung, Dominic Y.; Murray, R.Daniel; Urban, Lynn H.; Bailey, Kent R.; Tajik, A. Jamil

doi:10.1016/s0002-9149(99)00330-6

Cited by 59 publications

(46 citation statements)

References 26 publications

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“…Age differences might affect RV diastolic function, but have not been demonstrated to affect RV systolic function [34,35]. However, in order to exclude age-related factors as the underlying explanation of the differences found in the present study, a study with age-matched SScPAH and IPAH patients may elucidate the influence of age on RV contractility in PAH.…”

Section: Right Ventricular Contractility In Sscpah Mj Overbeek Et Almentioning

confidence: 65%

Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension

Overbeek¹,

Lankhaar²,

Westerhof³

et al. 2008

European Respiratory Journal

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Since systemic sclerosis (SSc) also involves the heart, the aim of the present study was to evaluate possible differences in right ventricular (RV) pump function between SScassociated pulmonary arterial hypertension (PAH; SScPAH) and idiopathic PAH (IPAH).In 13 limited cutaneous SScPAH and 17 IPAH patients, RV pump function was described using the pump function graph, which relates mean RV pressure (PRV) and stroke volume index (SVI). Differences in pump function result in shift or rotation of the pump function graph. PRV and SVI were measured using standard catheterisation. The hypothetical isovolumic PRV (PRV,iso) was estimated using a single-beat method. The pump function graph was approximated by a parabola:, where SVImax is the hypothetical maximal SVI at zero PRV, enabling calculation of SVImax. There were no differences in SVI and SVImax. Both PRV and PRV,iso were significantly lower in SScPAH than in IPAH (PRV 30.7¡8.5 versus 41.2¡9.4 mmHg; PRV,iso 43.1¡12.4 versus 53.5¡10.0 mmHg). Since higher pressures were found at similar SVI, the difference in the pump function graph results from lower contractility in SScPAH than in IPAH.Right ventricular contractility is lower in systemic sclerosis-associated pulmonary arterial hypertension than in idiopathic pulmonary arterial hypertension.

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Section: Right Ventricular Contractility In Sscpah Mj Overbeek Et Almentioning

confidence: 65%

Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension

Overbeek¹,

Lankhaar²,

Westerhof³

et al. 2008

European Respiratory Journal

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“…[4][5][6] In an effort to assess non-invasively RV and RA function we used indexes derived from two-dimensional and Doppler echocardiography similar to those used in the left side of the heart. 29,30 The estimation of right chambers dimensions by any method makes geometric assumptions that have not extensively validated. The area was chosen in this study because it has been used in patients with variable RA and RV size.…”

Section: Effects Of Antihypertensive Treatmentmentioning

confidence: 99%

“…However, the tricuspid flow velocity pattern is also affected by many other factors such as RA function, RV systolic function and RV minimum pressure. 29,30 Thus, RA function was only indirectly investigated.…”

Section: Effects Of Antihypertensive Treatmentmentioning

confidence: 99%

Right atrial function in hypertensive patients: effects of antihypertensive therapy

Dernellis¹

2001

J Hum Hypertens

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Objectives: The effects (16 weeks) of oral antihypertensive drugs on right atrial (RA) function were evaluated by two-dimensional and Doppler echocardiography in 64 patients with mild-to-moderate essential hypertension. Thirty-two age-and sex-matched normal subjects served as controls. Background: Hypertension alters the diastolic properties of the left ventricle and disturbs the left atrial contractile activities. RA performance may also alter in essential hypertension. Methods: From the tricuspid flow velocity curves the E/A ratio, the velocity-time integrals (Ei and Ai, respectively) as well as the sum, TTi ‫؍‬ Ei ؉ Ai, were measured. RA active contribution (RAAC) was expressed as the ratio RAAC ‫؍‬ Ai/TTi. Results: RA-A/E ratio, RA-Ai and RAAC were increased while RA-TTi were decreased in hypertensives compared to controls, P Ͻ 0.0001 for all comparisions. After

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“…All invasive and noninvasive techniques evaluating RV performance have important limitations due to the complex geometry of the right ventricle [3][4][5][6][7][8][9][10][11][12][13][14][15]. The introduction of Doppler measurement of myocardial wall velocities (tissue Doppler imaging; TDI) and the recently developed strain rate imaging (SRI) technique have made a more adequate assessment of global and regional systolic and diastolic RV function possible [16][17][18][19][20][21][22][23].…”

mentioning

confidence: 99%

Assessment of right ventricular function by strain rate imaging in chronic obstructive pulmonary disease

Vitarelli

Conde

Cimino

et al. 2006

European Respiratory Journal

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The purpose of the current study was to compare right ventricular (RV) myocardial wall velocities (tissue Doppler imaging) and strain rate imaging (SRI) parameters with conventional echocardiographic indices evaluating RV function in chronic obstructive pulmonary disease (COPD) patients.In total, 39 patients with COPD and 22 healthy subjects were included in the current study. Seventeen patients had pulmonary artery pressure ,35 mmHg (group I) and 22 patients had pulmonary artery pressure .35 mmHg (group II). Tissue Doppler imaging, strain and strain rate (SR) values were obtained from RV free wall (FW) and interventricular septum. Respiratory function tests were performed (forced expiratory volume in one second/vital capacity (FEV1/VC) and carbon monoxide diffusion lung capacity per unit of alveolar volume (DL,CO/VA)).Strain/SR values were reduced in all segments of group II patients compared with group I patients and controls with lowest values at basal FW site. A significant relationship was shown between peak systolic SR at basal FW site and radionuclide RV ejection fraction. A significant relationship was shown between peak systolic SR at basal FW site and DL,CO/VA and FEV1/VC.In conclusion, in chronic obstructive pulmonary disease patients, strain rate imaging parameters can determine right ventricular dysfunction that is complementary to conventional echocardiographic indices and is correlated with pulmonary hypertension and respiratory function tests.

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Effects of age and physiologic variables on right ventricular filling dynamics in normal subjects

Cited by 59 publications

References 26 publications

Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension

Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension

Right atrial function in hypertensive patients: effects of antihypertensive therapy

Assessment of right ventricular function by strain rate imaging in chronic obstructive pulmonary disease

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