Right atrial function in hypertensive patients: effects of antihypertensive therapy

Abstract

Objectives: The effects (16 weeks) of oral antihypertensive drugs on right atrial (RA) function were evaluated by two-dimensional and Doppler echocardiography in 64 patients with mild-to-moderate essential hypertension. Thirty-two age-and sex-matched normal subjects served as controls. Background: Hypertension alters the diastolic properties of the left ventricle and disturbs the left atrial contractile activities. RA performance may also alter in essential hypertension. Methods: From the tricuspid flow velocity curves the E/A ratio, the velocity-time integrals (Ei and Ai, respectively) as well as the sum, TTi ‫؍‬ Ei ؉ Ai, were measured. RA active contribution (RAAC) was expressed as the ratio RAAC ‫؍‬ Ai/TTi. Results: RA-A/E ratio, RA-Ai and RAAC were increased while RA-TTi were decreased in hypertensives compared to controls, P Ͻ 0.0001 for all comparisions. After

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