Effects of Age and Diet on the Development of the Pancreas and the Synthesis and Secretion of Pancreatic Enzymes in the Young Pig

Owsley, W. F.; Orr, Deborah; Tribble, L. F.

doi:10.2527/jas1986.632497x

Cited by 91 publications

(52 citation statements)

References 10 publications

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“…In that context, it is interesting to note that equine pancreatic tissue lipase was more dominant (1090 6 285.3 U/mg of DNA) than pancreatic amylase (59.5 6 9.8 U/mg of DNA) (Lorenzo-Figueras et al, 2007). The influence of diet on relative and absolute amounts of pancreatic enzymes is well established in other species, particularly in rats and swine (Wicker et al, 1984;Owsley et al, 1986). In rats, high dietary carbohydrate intake increased amylase synthesis in pancreatic lobules and also increased mRNA-directed synthesis of amylase in the translation system in vitro (Wicker et al, 1984).…”

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Effects of feeding state on glycaemic and insulinaemic responses to a starchy meal in horses: a methodological approach

Vervuert

Klein

Coenen

2009

Animal

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A standardised methodology is required for classification of starchy diets. One important question is what feeding status is optimal to describe glycaemic and insulinaemic responses to the respective starchy diet. Four horses were fed, in a randomised order, four different feeding protocols relative to offering hay before or after cracked corn (CC): (i) ad libitum hay for 12 h before feeding CC and ad libitum hay after CC intake for 9 h (1CC1), (ii) ad libitum hay for 12 h before feeding CC and no hay after CC intake for 9 h (1CC2), (iii) feed restriction for 12 h before feeding CC and ad libitum hay after CC intake for 9 h (2CC1) and (iv) 1.2 kg hay/100 kg body weight (BW) per day, divided into two equal portions and offered at 0900 h and 1900 h, feed restriction for 12 h before feeding CC and no hay after CC intake for 9 h (2CC2). CC intake was adjusted to a starch intake of 2 g/kg BW. The different hay offerings did not affect basal plasma glucose and insulin levels. A significant rise in plasma glucose and insulin was found after CC intake for all diets. The highest peak glucose levels were analysed for 2CC1, and the lowest glucose peaks were found for 1CC2 (diet P , 0.05). The highest insulin peaks were monitored for 2CC1 (31.27 6 18.19 mU/ml) and lower peaks for 1CC2 (13.36 6 2.93 mU/ml) (diet P , 0.05). Insulin for 2CC2 and 1CC2 returned to resting values about 300 min after CC feeding. For 1CC1 and 2CC1, insulin levels were still above resting levels 510 min after CC intake (diet P , 0.05). The present data suggest that feed restriction for 12 h before feeding the starchy diet and no further roughage intake during blood sampling period provide the best-defined conditions. Keywords: feed restriction, starch intake, glucose, insulin, horses Implications A standardised methodology is required for classification of starchy diets (e.g. grain processing techniques) on glycaemic and insulinaemic responses in horses. Differences in results obtained for horses might be due to differences in experimental protocols. The present data suggest that feed restriction for 12 h before feeding the starchy diet and no further ingestion of roughage during the blood sampling period provides the best-defined conditions. Hay is a very heterogeneous feedstuff (e.g. large differences in nutrient composition or total amount of hay consumed during ad libitum access); therefore, a precise description of the side effects of hay composition on metabolic responses is hard to define. IntroductionIn horses, several studies have been conducted to describe glycaemic and insulinaemic responses to a starchy meal with a focus on grain origin (Stull and Rodiek, 1988; JoseCunilleras et al., 2004;Rodiek and Stull, 2007), different grain processing techniques (Vervuert et al., 2003(Vervuert et al., , 2004(Vervuert et al., , 2007(Vervuert et al., and 2008a or the interaction between starch and other nutrients like fiber (Stull and Rodiek, 1988;Radicke et al., 1994;Pagan and Harris, 1999;Harris et al., 2005;Vervuert et al., 2008b and2008c) or fat (...

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confidence: 99%

Effects of feeding state on glycaemic and insulinaemic responses to a starchy meal in horses: a methodological approach

Vervuert

Klein

Coenen

2009

Animal

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“…Tem-se constatado que a proteína oriunda do soro do leite é qualitativamente superior à de outros produtos, como o farelo de soja e a farinha de peixe, uma vez que a disponibilidade de seus aminoácidos é alta (Bertol et al, 1996). Quando alimentados com soro de leite, observa-se melhor atividade de amilase, quimotripsina e tripsina no intestino dos leitões (Owsley et al, 1986). Com isso, pode-se ter melhor hidrólise da fração proteica e de carboidratos da dieta no intestino quando do fornecimento de soro de leite para leitões, resultando em melhor aproveitamento dos nutrientes com consequente melhora na conversão alimentar.…”

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Leitões recém-desmamados alimentados com dietas contendo proteína láctea e zinco suplementar

et al. 2010

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RESUMO -Avaliaram-se os efeitos da utilização de proteína láctea ou zinco suplementar na dieta sobre o desempenho, os pesos relativos do intestino delgado e fígado, a morfologia intestinal e as concentrações séricas de IGF-I (fator de crescimento semelhante à insulina), hormônio do crescimento e zinco em leitões. O experimento teve duração de 14 dias e foi realizado com 60 leitões desmamados aos 21 dias de idade (5,43 + 0,46 kg), em delineamento de blocos casualizados, em fatorial 2 × 2, composto de dois níveis de proteína láctea (com e sem, 4%) e dois de zinco (com e sem, 2.250 ppm) na dieta. No período de 1 a 7 dias de experimento, o zinco proporcionou melhor conversão alimentar e, no período de 1 a 14 dias, promoveu maior pesos aos 14 dias e maior ganho de peso. O fornecimento de proteína láctea na dieta piorou a conversão alimentar nas duas fases (de 1 a 7 dias e de 1 a 14 dias de experimento) e resultou em menor profundidade de cripta no jejuno aos 7 dias e maior altura de vilosidade aos 14 dias de experimento. Aos 7 dias de experimento, Houve interação proteína láctea e zinco para a relação altura de vilosidades:profundidade de criptas do jejuno, a qual foi também maior nos animais recebendo proteína láctea. A adição de zinco na dieta reduziu a concentração de IGF-I e o peso relativo do fígado aos 14 dias de experimento, enquanto o uso de proteína láctea aumentou a concentração de IGF-I. A inclusão de proteína láctea melhorou a conversão alimentar, influenciou a morfologia intestinal e aumentou a concentração de IGF-I, mas a suplementação de zinco não foi eficiente para alterar os níveis de hormônio do crescimento no organismo.Palavras-chave: IGF-I, morfologia intestinal, órgãos, produto lácteo, vilosidades Weaned piglets fed diets with milk protein and supplemental zinc ABSTRACT -It was evaluated the effects of using milk protein or supplemental zinc in the diet on performance, relative weights of small intestine and liver, intestine morphology and IGF-I (insulin-like growth factor) serum concentrations, growth hormone and zinc in piglets. The experiment lasted 14 days and it was carried out using 60 piglets weaned at 21 days of age (5.43 + 0.46 kg) in a complete random design, in a 2 × 2 factorial composed of two levels of milk protein (with and without, 4%) and two levels of zinc (with or without, 2,250 ppm) in the diet. In the 1-7 day experiment period, zinc provided better feed conversion and the in the 1-14 day experiment period, it promoted higher body weight at 14 days and higher weight gain. Supply of milk protein in the diet worsened feed conversion in the two phases (from 1 to 7 days and from 1 to 14 days of the experiment) and it resulted in a lower crypts depth in the jejunum and a higher villous height on day 14 of the experiment.On the 7 th day of the experiment, there was an interaction among milk protein and supplemental zinc for villous height:crypts depth relationship, which was also higher for animals fed milk protein. The addition of zinc in the diet reduced insuline-like growth factor...

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“…O peso absoluto do pâncreas aumentou (P<0,05) com a idade após o desmame (Tabela 6), indicando maior desenvolvimento e maturação da capacidade digestiva dos animais com as novas dietas (Owsley et al, 1986). Vente-Spreeuwenberg et al (2003) também verificaram aumento do peso absoluto do pâncreas entre 3 e 7 dias pós-desmame.…”

Section: Figure 3 -Scan Eletronmicrografies Of Jejuni (J) From Weaninunclassified

Efeitos de fontes protéicas na dieta sobre a morfologia intestinal e o desenvolvimento pancreático de leitões recém-desmamados

et al. 2005

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RESUMO -Objetivou-se neste trabalho analisar os efeitos do uso de hidrolisado protéico do conteúdo celular de levedura (HPCCL), da proteína isolada de soja (PIS), do hidrolisado protéico de mucosa intestinal de suínos (HPMIS) e do leite em pó integral em substituição parcial ao farelo de soja sobre a morfologia do intestino delgado e o desenvolvimento pancreático de leitões aos 7 e 14 dias pós-desmame. Foram utilizados 44 leitões desmamados aos 21 dias de idade, com peso de 5,5 ± 0,6 kg, alimentados desde o desmame com as seguintes dietas isonutritivas: FS -ração à base de milho e farelo de soja; LPI -ração FS + leite em pó integral; LPI+HPMIS -ração LPI mais HPMIS; LPI+PIS -ração LPI mais PIS; LPI+HPCCL -ração LPI mais HPCCL. Os tratamentos não influenciaram a morfologia intestinal dos leitões, evidenciando que nenhuma das fontes protéicas utilizadas foi capaz de minimizar os efeitos deletérios da mudança da alimentação sobre a vilosidade intestinal. Os animais alimentados com LPI+PIS e LPI+HPMIS apresentaram, aos sete dias pós-desmame, o maior desenvolvimento pancreático. Concluiu-se, portanto, que todas as fontes protéicas estudadas foram igualmente adequadas para a formulação de dietas de desmame.Palavras-chave: epitélio intestinal, leite em pó, leitões, proteína hidrolisada Effects of Feeding Protein Sources on Morphology and Pancreas Development for Weaned PigletsABSTRACT -This trial was carried out to evaluate the effects of replacing soybean meal with hydrolyzed protein of the cellular content of yeast (HPCCY), isolated protein of soy (IPS), hydrolyzed protein of intestinal mucosa membrane of swine (HPIMS) and dried whole milk on intestinal mucosa membrane morphology and pancreas development of weaned pigs at 7 and 14 days post weaning. Fourty-four piglets (averaging 5.5 ± 0.6 kg) were fed the following isonutritive diets: SM -yellow corn-soybean meal based diet; DWM -SM plus dried whole milk; DWM+HPIMS -DWM plus HPIMS; DWM+IPS -DWM plus IPS; DWM+HPCCY -DWM plus HPCCY. The treatments did not influence the pig intestinal structure, showing that none of the protein sources minimized the harmful effects of feeding change on the intestinal epithelium. DWM+HPIMS and DWM+IPS provided the greatest pancreatic weight at 7 days post weaning. It was concluded that all studied protein sources were adequate to formulate diets for weaned piglets.

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Effects of Age and Diet on the Development of the Pancreas and the Synthesis and Secretion of Pancreatic Enzymes in the Young Pig

Cited by 91 publications

References 10 publications

Effects of feeding state on glycaemic and insulinaemic responses to a starchy meal in horses: a methodological approach

Effects of feeding state on glycaemic and insulinaemic responses to a starchy meal in horses: a methodological approach

Leitões recém-desmamados alimentados com dietas contendo proteína láctea e zinco suplementar

Efeitos de fontes protéicas na dieta sobre a morfologia intestinal e o desenvolvimento pancreático de leitões recém-desmamados

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