Effects of affective pictures on pain sensitivity and cortical responses induced by laser stimuli in healthy subjects and migraine patients

Tommaso, Marina de; Calabrese, Rita; Vecchio, Eleonora; Francesco, Vito De Vito; Lancioni, Giulio E.; Livrea, Paolo

doi:10.1016/j.ijpsycho.2009.08.004

Cited by 31 publications

(30 citation statements)

References 52 publications

(77 reference statements)

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“…Our data show augmentation of pain during viewing negative emotional pictures which has been also reported in previous studies (de Wied and Verbaten, 2001; Kenntner-Mabiala and Pauli, 2005; Godinho et al, 2006; Kenntner-Mabiala et al, 2008; de Tommaso et al, 2009; Roy et al, 2009; Ploner et al, 2011). In the peri-stimulus interval, none of the components showed stronger amplitudes during negative than positive or neutral emotional pictures, and in each independent component the positive emotional pictures showed the strongest activation in at least one time interval.…”

Section: Discussionsupporting

confidence: 91%

Emotional modulation of experimental pain: a source imaging study of laser evoked potentials

Stančák¹,

Fallon²

2013

Front. Hum. Neurosci.

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Negative emotions have been shown to augment experimental pain. As induced emotions alter brain activity, it is not clear whether pain augmentation during noxious stimulation would be related to neural activation existing prior to onset of a noxious stimulus or alternatively, whether emotional stimuli would only alter neural activity during the period of nociceptive processing. We analyzed the spatio-temporal patterns of laser evoked potentials (LEPs) occurring prior to and during the period of cortical processing of noxious laser stimuli during passive viewing of negative, positive, or neutral emotional pictures. Independent component analysis (ICA) was applied to series of source activation volumes, reconstructed using local autoregressive average model (LAURA). Pain was the strongest when laser stimuli were associated with negative emotional pictures. Prior to laser stimulus and during the first 100 ms after onset of laser stimulus, activations were seen in the left and right medial temporal cortex, cerebellum, posterior cingulate, and rostral cingulate/prefrontal cortex. In all these regions, positive or neutral pictures showed stronger activations than negative pictures. During laser stimulation, activations in the right and left anterior insula, temporal cortex and right anterior and posterior parietal cortex were stronger during negative than neutral or positive emotional pictures. Results suggest that negative emotional stimuli increase activation in the left and right anterior insula and temporal cortex, and right posterior and anterior parietal cortex only during the period of nociceptive processing. The role of background brain activation in emotional modulation of pain appears to be only permissive, and consisting in attenuation of activation in structures maintaining the resting state of the brain.

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Section: Discussionsupporting

confidence: 91%

Emotional modulation of experimental pain: a source imaging study of laser evoked potentials

Stančák¹,

Fallon²

2013

Front. Hum. Neurosci.

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“…On the other hand, one could speculate that the inefficacy of a sham rTMS at the trigeminal zone in controls may be caused by the somatotopy of placebo effect, such as that suggested by Benedetti et al [34]. The modulation of nociceptive processing has peculiar aspects in migraine patients, as it is less evident under distraction in cognitive tasks and is normally induced under distraction by affective images [27, 35]. The sham TMS procedure induced a placebo effect on nociceptive processing in migraine patients, without an evident effect on subjective pain rating.…”

Section: Discussionmentioning

confidence: 99%

Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine

et al. 2010

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The aim of this study was to examine the effects of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex (M1) on subjective pain and evoked responses induced by laser stimulation (LEPs) of the contralateral hand and supraorbital zone in a cohort of migraine patients without aura during the inter-critical phase, and to compare the effects with those of non-migraine healthy controls. Thirteen migraine patients and 12 sex- and age-matched controls were evaluated. Each rTMS session consisted of 1,800 stimuli at a frequency of 5 Hz and 90% motor threshold intensity. Sham (control) rTMS was performed at the same stimulation position. The vertex LEP amplitude was reduced at the trigeminal and hand levels in the sham-placebo condition and after rTMS to a greater extent in the migraine patients than in healthy controls, while the laser pain rating was unaffected. These results suggest that HF rTMS of motor cortex and the sham procedure can both modulate pain-related evoked responses in migraine patients.

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“…The N1 component, which refers to the earliest stage of perception processing [10, 34], was not involved by the changes occurring during the VR representation. Accordingly, N1 changes occurred neither during the contemporary vision of images with different affective content in migraine patients and controls, nor during the vision of beautiful pictures in healthy volunteers [12, 14]. The vertex complex was modulated in an increasing direction during the virtual hospital immersion in migraine, while a quite opposite trend was observed in healthy controls, in accord with the trend of pain rating.…”

Section: Discussionmentioning

confidence: 99%

“…Migraine is a disorder of neurovascular origin, which may become chronic and invalidating. Distraction induced by cognitive task was ineffective in modulating pain processing in chronic migraine [16], differently from the vision of affective images which was able to reduce LEPs amplitude in the same type of patients [14]. …”

Section: Introductionmentioning

confidence: 99%

Virtual Visual Effect of Hospital Waiting Room on Pain Modulation in Healthy Subjects and Patients with Chronic Migraine

Tommaso¹,

Ricci²,

Laneve³

et al. 2013

Pain Research and Treatment

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Environmental context has an important impact on health and well being. We aimed to test the effects of a visual distraction induced by classical hospital waiting room (RH) versus an ideal room with a sea view (IH), both represented in virtual reality (VR), on subjective sensation and cortical responses induced by painful laser stimuli (LEPs) in healthy volunteers and patients with chronic migraine (CM). Sixteen CM and 16 controls underwent 62 channels LEPs from the right hand, during a fully immersive VR experience, where two types of waiting rooms were simulated. The RH simulated a classical hospital waiting room while the IH represented a room with sea viewing. CM patients showed a reduction of laser pain rating and vertex LEPs during the IH vision. The sLORETA analysis confirmed that in CM patients the two VR simulations induced a different modulation of bilateral parietal cortical areas (precuneus and superior parietal lobe), and superior frontal and cingulate girus, in respect to controls. The architectural context may interfere with pain perception, depending upon the status of subject. Many variables may change patients' outcome and support the use of VR technology to test the best conditions for their management.

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Effects of affective pictures on pain sensitivity and cortical responses induced by laser stimuli in healthy subjects and migraine patients

Cited by 31 publications

References 52 publications

Emotional modulation of experimental pain: a source imaging study of laser evoked potentials

Emotional modulation of experimental pain: a source imaging study of laser evoked potentials

Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine

Virtual Visual Effect of Hospital Waiting Room on Pain Modulation in Healthy Subjects and Patients with Chronic Migraine

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