Virtual Visual Effect of Hospital Waiting Room on Pain Modulation in Healthy Subjects and Patients with Chronic Migraine

Tommaso, Marina de; Ricci, Katia; Laneve, Luigi; Savino, Nicola; Antonaci, Vincenzo; Livrea, Paolo

doi:10.1155/2013/515730

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…A similar dearth of distractive elements may also explain the differing results seen in a comparable study investigating the effect of visual distraction through VR on EPs and pain scores 43 . In that study, participating healthy volunteers and chronic migraine patients viewed a presentation of virtual images representing either a hospital waiting room or an imaginary waiting room with coastal views.…”

Section: Discussionmentioning

confidence: 96%

The effect of Virtual Reality on evoked potentials following painful electrical stimuli and subjective pain

Lier¹,

Oosterman

Aßmann³

et al. 2020

Sci Rep

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Background: Virtual reality (VR) has been shown to reduce pain, however outcome parameters of previous studies have primarily been of a subjective nature and susceptible to bias. This study investigated the effect of VR on cortical processing of evoked potentials (EPs) and subjectively reported pain. Additionally, we explored whether subjects' demographic and personal characteristics modulated the effect of VR analgesia. Methods: Three VR conditions were compared in a randomized cross-over study of 30 healthy volunteers: Passive VR (i.e. no interaction possible with the virtual world), active VR (interactive virtual environment) and no VR (black screen). Subjects received noxious electrical stimuli at random intervals during all conditions. EPs, recorded at Cz, were extracted time locked to stimuli. Pain scores were reported after each condition. Results: Active VR significantly decreased pain scores and amplitudes of N1 and P3. Passive VR had no analgesic effect. Age was significantly correlated to pain scores, with older subjects demonstrating larger effects of VR. Gender, game experience, and susceptibility for immersion, did not influence VR analgesia. Conclusion: Active VR decreases preperceptual and perceptual brain activity following painful electrical stimuli, corresponding with reduced pain experience. VR has potential to serve as a non-pharmacologic treatment for pain, particularly in elderly patients.

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Section: Discussionmentioning

confidence: 96%

The effect of Virtual Reality on evoked potentials following painful electrical stimuli and subjective pain

Lier¹,

Oosterman

Aßmann³

et al. 2020

Sci Rep

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“…Thus, gamma oscillations provide a powerful tool for understanding the brain mechanisms underlying human emotional processing ( Kotecha et al, 2009 ; Erk et al, 2010 ). Previous researches also provided that different effective pictures or contexts may interfere with the pain perception ( de Tommaso et al, 2009 , 2013 ). In the present study, contour maps showed that gamma activity for the M100 component of the response was primarily distributed around bilateral occipital cortices, and we surmise that it reflects visual processing of negative emotional stimuli.…”

Section: Discussionmentioning

confidence: 99%

Interictal Abnormalities of Neuromagnetic Gamma Oscillations in Migraine Following Negative Emotional Stimulation

Fan

Chen

et al. 2018

Front. Behav. Neurosci.

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Here, we aimed to investigate brain activity in migraineurs in response to emotional stimulation. Magnetoencephalography (MEG) was used to examine 20 patients with episodic migraine (EM group), 15 patients with chronic migraine (CM group), and 35 healthy participants (control group). Neuromagnetic brain activity was elicited by emotional stimulation using photographs of facial expressions. We analyzed the latency and amplitude of M100 and M170 components and used Morlet wavelet and beamformers to analyze the spectral and spatial signatures of MEG signals in gamma band (30–100 Hz). We found that the timing and frequency of MEG activity differed across the three groups in response negative emotional stimuli. First, peak M170 amplitude was significantly lower in the CM group than in the control group. Second, compared with the control group, the average spectral power was significantly lower in the EM group and CM group at M100 and M170. Third, the average spectral powers of the M100 and M170 in the CM group were negatively correlated with either HAM-D scores or migraine attack frequency. No significant differences across groups was found for positive or neutral emotional stimuli. Furthermore, after negative emotional stimuli, the MEG source analysis demonstrated that the CM group showed a significantly higher percentage of amygdala activation than the control group for M100 and M170. Thus, during headache free phases, migraineurs have abnormal brain activity in the gamma band in response to negative emotional stimuli.Trial Registration: ChiCTR-RNC-17012599. Registered 7 September, 2017.

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“…Recently, in a group of patients with episodic migraines, we found reductions in the functional connectivity between the visuo-spatial system and the so-called default mode network between attacks [ 47 ], while during attacks, the connectivity was reduced between the executive and dorso-ventral visual attention networks [ 48 ], stressing that occipital areas could be involved in the attentional processes to pain and in some aspects of pain representation [ 49 ]. Notably, the visual presentation of affective pictures modulates occipital functional activation and, at the same time, pain perception differently in patients with CM than it does in HCs [ 50 ], perhaps through direct occipital-to-brainstem trigeminal nuclei connections [ 51 ]. Therefore, our results in patients with CM tend to show the morphological correlates of aberrant attentional processes to head pain and of anomalous representations of pain.…”

Section: Discussionmentioning

confidence: 99%

Cerebral gray matter volume in patients with chronic migraine: correlations with clinical features

et al. 2017

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BackgroundTo date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morphometry (VBM) analyses to investigate the gray matter (GM) volume of the whole brain in patients affected by CM. Our aim was to investigate whether fluctuations in the GM volumes were related to the clinical features of CM.MethodsTwenty untreated patients with CM without a past medical history of medication overuse underwent 3-Tesla MRI scans and were compared to a group of 20 healthy controls (HCs). We used SPM12 and the CAT12 toolbox to process the MRI data and to perform VBM analyses of the structural T1-weighted MRI scans. The GM volume of patients was compared to that of HCs with various corrected and uncorrected thresholds. To check for possible correlations, patients’ clinical features and GM maps were regressed.ResultsInitially, we did not find significant differences in the GM volume between patients with CM and HCs (p < 0.05 corrected for multiple comparisons). However, using more-liberal uncorrected statistical thresholds, we noted that compared to HCs, patients with CM exhibited clusters of regions with lower GM volumes including the cerebellum, left middle temporal gyrus, left temporal pole/amygdala/hippocampus/pallidum/orbitofrontal cortex, and left occipital areas (Brodmann areas 17/18). The GM volume of the cerebellar hemispheres was negatively correlated with the disease duration and positively correlated with the number of tablets taken per month.ConclusionNo gross morphometric changes were observed in patients with CM when compared with HCs. However, using more-liberal uncorrected statistical thresholds, we observed that CM is associated with subtle GM volume changes in several brain areas known to be involved in nociception/antinociception, multisensory integration, and analgesic dependence. We speculate that these slight morphometric impairments could lead, at least in a subgroup of patients, to the development and continuation of maladaptive acute medication usage.Electronic supplementary materialThe online version of this article (10.1186/s10194-017-0825-z) contains supplementary material, which is available to authorized users.

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Virtual Visual Effect of Hospital Waiting Room on Pain Modulation in Healthy Subjects and Patients with Chronic Migraine

Cited by 21 publications

References 37 publications

The effect of Virtual Reality on evoked potentials following painful electrical stimuli and subjective pain

The effect of Virtual Reality on evoked potentials following painful electrical stimuli and subjective pain

Interictal Abnormalities of Neuromagnetic Gamma Oscillations in Migraine Following Negative Emotional Stimulation

Cerebral gray matter volume in patients with chronic migraine: correlations with clinical features

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