Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine

Tommaso, Marina de; Brighina, Filippo; Fierro, Brigida; Francesco, Vito Devito; Santostasi, R.; Sciruicchio, Vittorio; Vecchio, Eleonora; Serpino, Claudia; Lamberti, Paolo; Livrea, Paolo

doi:10.1007/s10194-010-0247-7

Cited by 30 publications

(21 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies examining the effect of rTMS on experimental pain in migraineurs are sparse. One study found a reduced laser-evoked potentials amplitude over vertex in migraineurs compared to controls after 5 Hz rTMS of M1, but the rTMS-effect did not differ from sham stimulation and the pain rating was unaffected (de Tommaso et al , 2010). Based on these studies and our results, rTMS seems to increase pain thresholds and decrease pain ratings in healthy subjects, but only affect pain ratings in migraineurs.…”

Section: Discussionsupporting

confidence: 73%

Non-invasive cortical modulation of experimental pain in migraine

Uglem

Omland

Engstrøm

et al. 2016

Clinical Neurophysiology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 73%

Non-invasive cortical modulation of experimental pain in migraine

Uglem

Omland

Engstrøm

et al. 2016

Clinical Neurophysiology

View full text Add to dashboard Cite

“…Numerous studies [60] confirmed the analgesic effect induced by non-invasive stimulation of the motor cortex in patients with pain and specifically FM [61][62], though the level of evidence of their efficacy remains low [63]. In a previous study conducted in healthy controls and migraine patients, we observed that a single session of high frequency rTMS of the motor cortex reduced the LEP vertex complex in both groups, with a clear sham effect in migraine patients [64]. The motor cortex activation induced by finger tapping could not be able to reduce the pain-related cortical responses.…”

Section: Effects Of Movement On Laser Evoked Responsessupporting

confidence: 53%

Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background Experimental and clinical studies suggested an analgesic effect on chronic pain by motor cortex activation. The present study explored the complex mechanisms of interaction between motor and pain during performing the slow and fast finger tapping task alone and in concomitant with nociceptive laser stimulation. Method The participants were 38 patients with fibromyalgia (FM) and 21 healthy subjects. We used a simultaneous multimodal method of laser-evoked potentials and functional near-infrared spectroscopy to investigate metabolic and electrical changes during the finger tapping task and concomitant noxious laser stimulation. Functional near-infrared spectroscopy is a portable and optical method to detect cortical metabolic changes. Laser-evoked potentials are a suitable tool to study the nociceptive pathways function. Results We found a reduced tone of cortical motor areas in patients with FM compared to controls, especially during the fast finger tapping task. FM patients presented a slow motor performance in all the experimental conditions, requesting rapid movements. The amplitude of laser evoked potentials was different between patients and controls, in each experimental condition, as patients showed smaller evoked responses compared to controls. Concurrent phasic pain stimulation had a low effect on motor cortex metabolism in both groups nor motor activity changed laser evoked responses in a relevant way. There were no correlations between Functional Near-Infrared Spectroscopy (FNIRS) and clinical features in FM patients.

show abstract

“…Non-invasive vagus nerve stimulation did not modify subjective pain ratings of laser stimuli, consistent with other studies exploring the effects of single sessions of cortical or transcutaneous stimulation on trigeminal pain-related cortical responses ( de Tommaso et al, 2010 ; Vecchio et al, 2016 , 2017 ). This finding was expected as it is in agreement with the largely accepted hypothesis that LEPs are not the neurophysiological signature of subjective pain ratings, while they rather express the functional status of pain pathways ( Mouraux and Iannetti, 2009 ).…”

Section: Discussionsupporting

confidence: 90%

Effect of Non-invasive Vagus Nerve Stimulation on Resting-State Electroencephalography and Laser-Evoked Potentials in Migraine Patients: Mechanistic Insights

Vecchio

Bassez

Ricci

et al. 2018

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

A recent multicenter trial provided Class I evidence that for patients with an episodic migraine, non-invasive vagus nerve stimulation (nVNS) significantly increases the probability of having mild pain or being pain-free 2 h post-stimulation. Here we aimed to investigate the potential effect of nVNS in the modulation of spontaneous and pain related bioelectrical activity in a subgroup of migraine patients enrolled in the PRESTO trial by using resting-state electroencephalography and trigeminal laser-evoked potentials (LEPs). LEPs were recorded for 27 migraine patients who received active or sham nVNS over the cervical vagus nerve. We measured power values for frequencies between 1–100 Hz in a resting-state condition and the latency and amplitude of N1, N2, and P2 components of LEPs in a basal condition during and after active or sham vagus nerve stimulation (T0, T1, T2). The P2 evoked by the right and the left trigeminal branch was smaller during active nVNS. The sham device also attenuated the P2 amplitude evoked by the left trigeminal branch at T1 and T2, but this attenuation did not reach significance. No changes were observed for N1 amplitude, N1, N2, P2 latency, or pain rating. nVNS induced an increase of EEG power in both slow and fast rhythms, but this effect was not significant as compared to the sham device. These findings suggest that nVNS acts on the cortical areas that are responsible for trigeminal pain control and pave the ground for future studies aimed at confirming the possible correlations with clinical outcomes, including the effect on symptoms that are directly correlated with trigeminal pain processing and modulation.

show abstract

Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine

Cited by 30 publications

References 41 publications

Non-invasive cortical modulation of experimental pain in migraine

Non-invasive cortical modulation of experimental pain in migraine

Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study

Effect of Non-invasive Vagus Nerve Stimulation on Resting-State Electroencephalography and Laser-Evoked Potentials in Migraine Patients: Mechanistic Insights

Contact Info

Product

Resources

About