Effects of Acetylsalicylic Acid in Preterm Preeclampsia Prevention

Changes in lipid metabolism from pregnancies with preeclampsia (PE) are a challenge for the obstetrician, because they contribute to the pathological chain and to some specific severe complications (severe hypertriglyceridemia of pregnancy, acute pancreatitis etc). Patients at risk for PE have higher levels of triglycerides, total and LDL cholesterol, compared to normotensive pregnant women. We searched the link between lipidic changes in pregnancies with PE and the way secondary prophylactic treatments with acetylsalicilic acid or low molecular weight heparin (LMWH) can influence the evolution of pregnancy, avoiding the severe complications of this disease. We identified patients at risk of developing PE and then applied a secondary prophylaxis with either a platelet antiaggregant (acetylsalycilic acid - a group of 36 patients) or an anticoagulant prophylaxis with LMWH � enoxaparin (a second group of 37 patients), aiming a decrease of severe complications of PIH/PE. The control group consisted of 33 pregnant women with risk factors for PE, without any secondary prophylaxis, according to actual guidelines. We periodically determined (at 14, 16-20 and 34 weeks of pregnancy) several biochemical parameters: triglycerides, uric acid, free fatty acids, total cholesterol and albuminemia. In the present paper we present the evolution of triglyceridemia in the studied groups, considering hypertriglyceridemia as an important prognostic factor for maternal complications in pregnancy. The most important result of our study is the statistically significant extremely low rate of complications in the treatment groups.

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confidence: 99%

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confidence: 99%

A Biochemical Marker of Preeclampsia - Hypertriglyceridemia - and the Impact of Secondary Prevention Therapy

Grigoriu¹,

Furtunescu²,

Găman³

et al. 2018

“…In case of pregnant women suffering from preeclampsia, the risk of death caused by cardiovascular factors is also high; in case of pregnant women who experience an early manifestation of the disease, the risk is extremely high [22,23]. Preeclampsia and cardiovascular diseases have surely in common physiopathological mechanisms and risk factors, such as obesity or diabetes mellitus; they may lead to preeclampsia, as well as to cardiovascular diseases during life [19,[23][24][25][26]. Even if the acute manifestation of the disease is more dangerous for the mother, preeclampsia may also affect the fetus, leading to an increased risk of spontaneous preterm birth, fetal growth retardation, oligohydramnios, as well as to an increased risk of perinatal death.…”

Section: Results and Discussion Clinical And Laboratory Markersmentioning

confidence: 99%

The Role of Several Angiogenesis Peptides Markers in the Management of Hypertensive Pregnant Women

Mihălceanu¹,

Dimitriu²,

Lazar³

et al. 2018

The objectives of the research herein are to detect if the modifications of sFlt-1 and PlGF can be correlated with the clinical and biochemical status of the hypertensive pregnant woman and if the sFlt-1/PlGF ratio is a good predictor for preeclampsia in case of the investigated patients. In the study herein, 100 pregnant women were evaluated; they were distributed in the following groups: The group of pregnant women diagnosed with HTN at the time of hospital admission � including 50 pregnant women, of which 16 pregnant women presented medium and severe forms of preeclampsia and 34 pregnant women with pregnancy-induced hypertension and 50 pregnant women with normal pregnancy evolution as control group. We have performed hematological and biochemical tests, using serum samples from all analyzed patients and measured the serum concentrations of sFlt-1 and PlGF angiogenic factors. We found a significant correlation between the value of the arterial blood pressure, the proteinuria, the serum creatinine and the AST, on one hand, and the sFlt-1/PlGF ratio, on the other hand. The ROC curve has emphasized the fact that the proteinuria (AUC = 0.849), the AST (AUC = 0.664), the value of the arterial blood pressure SBP/DBP (AUC = 0.683/0.631), the serum creatinine (AUC = 0.674) and the sFlt-1/PlGF ratio, at a cut off value = 200, are effective preeclampsia predictors. Similarly, statistically significant increase (p = 0.001) of the sFlt-1 serum concentration in case of the pregnant women from the PE group (14365�6464 pg/mL) and from the PIH group (9892�8443 pg/mL), compared to the control group (3278�1444 pg/mL) and, respectively, a significant decrease (p = 0.003) of the PlGF pro-angiogenic marker for the group of pregnant women suffering from preeclampsia (119.30�56.63 pg/mL) and from PIH (129.12�21.41 pg/mL), compared to the control group (327.57�59.62 pg/mL). The results obtained within this research show that sFlt-1/PlGF ratio represents an effective preeclampsia predictor, confirming the fact that the study of the angiogenic factors may help to analyze the stratification of the risk degree in HTN pregnant women.

“…Preeclampsia is one of the primary causes of maternal morbidity and mortality, affects both the mother and the fetus [2]. It is defined as gestational hypertension with a BP >140/90mmHg after 20 weeks of gestation accompanied by proteinuria > 300mg/24 h in a patient who has no history of hypertension or renal disease [3][4][5]. The main risk factors for preeclampsia are: obesity, diabetes, extreme maternal ages, nulliparity, personal history of preeclampsia, race [6].…”

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confidence: 99%

New Various Histopathological Findings of the Placenta in Preeclampsia

Luchian¹,

Nada²,

Dumitru³

et al. 2019

Preeclampsia represents a pregnancy-related disease which affects both the mother and the fetus. It�s an important cause of materno-fetal morbidity and mortality. The placenta seems to be the main cause because after placental removal preeclampsia is no longer present. Placental examination is crucial and can reveal important information about this disease. After careful examination, besides the classic findings, new and uncommon histopathological aspects of the placenta in preeclampsia were described. A short observational study was performed which included placentas from preeclampsia complicated pregnancies. The various histopathological findings of the placenta in preeclampsia were evaluated according to gestational age.