Effects of abamectin exposure on male fertility in rats: Potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation

Çelik-Özenci, Çiler; Taşatargil, Arda; Tekcan, Merih; Satı, Leyla; Gungör, Ece; Isbir, M.; Demir, Ramazan

doi:10.1016/j.yrtph.2011.09.001

Cited by 49 publications

(24 citation statements)

References 37 publications

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“…In our experiment, embryos treated with 1.25mg/L show poor limb formation, poor development of blood vessels, heart, feather germ layer and small size of embryo, with decreasing drug doses, effects were more prominent. Further Celik-Ozenci observed that AVM causes the inhibition of neuronal mitochondria activity, increase in activities of CASPASES-3 and 9 which indicates that AVM induces the apoptosis of the culture brain neurons through mitochondria injury [10]. In our study, embryos injected with increase in dose to 1.25mg/L showed ectopia viscera, with small eyes and heart developed, without limbs formation.…”

Section: Discussionsupporting

confidence: 60%

“…In mammals, abamectin administration to male rats causes decreased sperm count, motility and increased damage in seminiferous tubule. There is also an elevated level of 4-hydroxy-2-nonenal (4-HNE)modified proteins and poly (ADP-ribose) (PAR) expression, as markers for oxidative stress and poly (ADP-ribose) polymerase (PARP) activation, observed in rat testes exposed to abamectin [10]. In birds, the cytotoxic effects caused by low abamectin concentrations on the erythrocytes of female Japanese quails were investigated [11,12].…”

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confidence: 99%

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Effect of abamectin on development of chick embryo

Sardar¹

2020

PAB

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Abamectin is widely used as an insecticide and pesticide on crops. Despite of its beneficial uses it also induces some adverse effects like it causes infertility in farmers who frequently encounter abamectin. It is broadly used but little is known about its effects on avian. To check its teratogenic effects on developing chick embryo abamectin is injected into fertilized chick embryos. In chick embryo, gross anomalies and morphological changes are observed. The results of this experiment indicated that low dose of abamectin has adverse effects than that of high dose, as low dose of abamectin reduces the growth rate of developing chick embryo and delayed hatching. Moreover, hatched chicks are physically weak.

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Section: Discussionsupporting

confidence: 60%

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confidence: 99%

Effect of abamectin on development of chick embryo

Sardar¹

2020

PAB

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“…One of these pesticides, abamectin (ABM), is used extensively all over the world. Recently, we have shown that ABM administration was associated with decreased sperm count and motility and increased seminiferous tubule damage 78 . In addition, significant elevations in the 4-HNE (4-Hydroxynonenal, a marker of oxidative stress)-modified proteins were observed in testes of rats exposed to ABM.…”

Section: Overactivation Of Parp In Male Reproductionmentioning

confidence: 99%

Role of poly(ADP-ribose) polymerases in male reproduction

Çelik-Özenci

Taşatargil

2013

Spermatogenesis

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Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a wide variety of biological processes, including DNA repair and maintenance of genomic stability following genotoxic stress, and regulates the expression of various proteins at the transcriptional level as well as replication and differentiation. However, excessive activation of PARP has been shown to contribute to the pathogenesis of several diseases associated with oxidative stress (OS), which has been known to play a fundamental role in the etiology of male infertility. Based on the degree and type of the stress stimulus, PARP directs cells to specific fates (such as, DNA repair vs. cell death). A large volume of accumulated evidence indicates the presence of PARP and its homologs in testicular germ line cells and its activity may offer a key mechanism for keeping DNA integrity in spermatogenesis. On the other hand, a possible role of PARP overactivation in OS-induced male reproductive disorders and in human sperm is gaining significance in recent years. In this review, we focus on the findings about the importance of PARP-1 and PARP-2 in male reproduction and possible involvement of PARP overactivation in various clinical conditions associated with male infertility.

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“…Of particular priority for consideration should be the large variation found in sensitivity among different species and life stages (noted above) and whether a sufficient diversity of species has been tested to characterise the general toxicity of abamectin in the marine environment. In addition, environmentally relevant exposure times should be considered; for example, longer-term chronic exposure of adults to abamectin may be relevant if this substance accumulates in benthic sediments, potentially resulting in sub-lethal effects that modify reproductive stages (as observed in terrestrial studies Elbetieha & Da'as 2003, Celik-Ozenci et al 2011, Celik-Ozenci et al 2012. When combined with the understanding gained from future studies addressing these issues, our findings might then better inform decision-making regarding the use of abamectin in marine antifouling products, enabling the prevention of biofouling while also limiting unintended impacts in the marine environment.…”

Section: Discussionmentioning

confidence: 99%

Low sensitivity of reproductive life-stages in the Pacific oyster ( Crassostrea gigas ) to abamectin

et al. 2017

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Hard surfaces submerged in the marine environment often become colonised by macro-organisms unless the surfaces have some form of biofouling protection. While protective paints that contain tributyltin or copper work well to prevent biofouling, release of these materials into the environment has been shown to have wider negative impacts. Consequently, new low-release antifouling paints are being developed with alternative active ingredients, such as avermectins, yet little is known about their potential effects on non-target organisms in marine environments. Here we investigated the toxicity of a key avermectin, specifically abamectin, on several aspects of reproduction (sperm motility, fertilisation success, early larval development) in the Pacific oyster, Crassostrea gigas. Oyster reproduction was generally insensitive to the low concentrations of abamectin, although greater concentrations of abamectin did negatively affect all three endpoints - LOECs were 1000 μg l, 500 μg l, and 100 μg l abamectin for sperm motility, fertilisation success, and larval development, respectively. A similar pattern was found in the ECs of the three endpoints (mean ± SE) 934 ± 59 μg l, 1076.26 ± 725.61 μg l, and 140 ± 78 μg l abamectin (sperm motility, fertilisation success, and larval development, respectively). Together, these results clearly indicate that of the three endpoints considered, larval development was more sensitive to abamectin (lower LOEC, EC) than fertilisation success and sperm motility. Although more data are needed from a wider range of marine species and environments to fully assess potential toxicity effects on non-target organisms, our results highlight the potential utility of abamectin in low-release antifouling paints.

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Effects of abamectin exposure on male fertility in rats: Potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation

Cited by 49 publications

References 37 publications

Effect of abamectin on development of chick embryo

Effect of abamectin on development of chick embryo

Role of poly(ADP-ribose) polymerases in male reproduction

Low sensitivity of reproductive life-stages in the Pacific oyster ( Crassostrea gigas ) to abamectin

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