Effects of a Symbiotic on Gut Microbiota in Mexican Patients With End-Stage Renal Disease

Cruz-Mora, José; Martínez-Hernández, Norma Edith; Campo-López, Fabiola Martín del; Hörner, Daniela Viramontes; Vizmanos-Lamotte, Barbara; Muñoz‐Valle, José Francisco; García-García, Guillermo; Parra‐Rojas, Isela; Castro-Alarcón, Natividad

doi:10.1053/j.jrn.2014.05.006

Cited by 65 publications

(52 citation statements)

References 24 publications

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“…Previous studies indicated that the modulation of gut microbiota by probiotics facilitated the management of CKD. The probiotics could provide the nutrients for colonic epithelial cells and help to maintain the intestinal microbial balance . However, probiotics were found to be ineffective or less effective to reduce circulating uremic toxins .…”

mentioning

confidence: 99%

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

et al. 2019

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Background Chronic kidney disease (CKD) is a worldwide public health problem. Although accumulated data suggested that probiotic supplements played roles in CKD, the results remained controversial. Here, we performed a meta‐analysis to assess the effects of probiotic supplements on the CKD progression. Methods A systematic search was conducted through the PubMed, Embase and Cochrane databases until September 2018. Randomized controlled trials with control receiving placebo, evaluating the effects of probiotic supplements on CKD were included. Results A total of 10 randomized controlled trials in 8 countries were selected. In the meta‐analysis, urea level was significantly reduced in probiotics‐administrated non‐dialysis patients (mean differences (MD) = −30.01; 95% confidence interval (CI) = [−56.78, −3.25]; P = 0.03) while no significant change was found in the dialysis patients receiving probiotics (MD = 0.1; 95% CI = [−9.28, 9.48]; P = 0.98). Probiotic supplements also exhibited no effect on uric acid (MD = −0.43; 95% CI = [−1.19, 0.33]; P = 0.27), C‐reactive protein (MD = −0.48; 95% CI = [−1.29, 0.33]; P = 0.24), creatinine (MD = −0.18; 95% CI = [−0.82, 0.47]; P = 0.59), and estimated glomerular filtration rate (MD = 2.10; 95% CI = [−1.31, 5.52]; P = 0.23) of CKD patients. Conclusion Our results highlighted that probiotic supplements exerted a statistically significant effect on urea levels in non‐dialysis CKD population, while no evidence suggested that probiotics possessed meaningful impacts on the reduction of uric acid, C‐reactive protein, creatinine and estimated glomerular filtration rate preservation of CKD population.

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confidence: 99%

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

et al. 2019

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“…Despite the differences in the combination and doses of probiotic and prebiotics and the shortterm follow-up, studies with synbiotics seem to be better quality, in terms of methodological aspects compared to those with probiotics or prebiotics alone. Moreover, the overall result has been more consistent showing a reduction in PCS [141][142][143] or an increase in the relative abundance of fecal Bifidobacterium (Table 1) [141,144]. However, the benefits of probiotics and synbiotics in the reduction of PCS and IS appear to be associated with the sustained use of the therapy, since an increase in those toxins was observed when the supplementation was discontinued [134,141,145].…”

Section: Gut Ecosystem In Ckd and Immunitymentioning

confidence: 84%

The cross-talk between the kidney and the gut: implications for chronic kidney disease

Andrade

Ramos

Cuppari

2017

Nutrire

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In recent decades, special attention has been given to the potential association between the gut ecosystem and chronic diseases. Several features and complications of chronic kidney disease (CKD) may induce an unbalanced gut environment, leading to unfavorable consequences for a patient's health. The first section of this review is dedicated to a description of some aspects of gut microbiota and intestinal barrier physiology. The following section explores the impact of CKD on the gut ecosystem and intestinal barrier, particularly the association with uremic toxins, inflammation, and immunodeficiency. Finally, the review describes the state of the art of potential therapies with prebiotics, probiotics, and synbiotics employed to modulate the gut environment and to reduce the generation of colon-derived uremic toxins in CKD.

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“…lactis, 2,3g de inulina y 1,5g de omega-3 47 . Este mismo grupo de trabajo reportó cambios en la composición de la microbiota intestinal, con incrementos en la cuenta de bifidobacterias tras 2 meses de suplementación del mismo producto en 18 pacientes en terapia hemodiálisis 48 . Estos hallazgos han sido replicados por Rossi y Cols., quienes reportan una disminución en pCS, con incrementos en bifidobacterias tras suplementar por 6 semanas 15g de fibra en polvo (inulina, fructooligosacáridos y galactooligosacáridos) y una cápsula con 9 diferentes cepas de lactobacilos, bifidobacterias y estreptococos en 31 individuos con ERC grado 4-5 49 .…”

Section: Estrategias Terapéuticasunclassified

Alteraciones en el eje intestino-riñón durante la enfermedad renal crónica: causas, consecuencias y propuestas de tratamiento

Osuna-Padilla

Leal-Escobar

2017

Rev Esp Nutr Hum Diet

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La enfermedad renal crónica y el estado urémico se asocian con alteraciones en la permeabilidad intestinal y cambios en la microbiota intestinal, provocando una mayor producción y translocación de toxinas urémicas como sulfato de indoxilo (IS) y sulfato de p-cresilo (pCS), detonando una respuesta inflamatoria. El estado inflamatorio y el incremento en concentraciones séricas de IS y pCS se han asociado con una mayor mortalidad, mayor número de eventos cardiovasculares y mayores alteraciones en el metabolismo mineral y óseo. Se han estudiado diversas estrategias nutricionales y farmacológicas para modular la microbiota intestinal y mejorar las alteraciones en la permeabilidad intestinal, entre ellas la suplementación con probióticos, prebióticos y simbióticos, modificaciones en la composición de la dieta y uso de agentes adsorbentes. El objetivo del presente trabajo es realizar una revisión de las causas de las alteraciones intestinales y de la microbiota intestinal en el paciente con enfermedad renal crónica, analizando las consecuencias de dichos cambios y las intervenciones estudiadas hasta la actualidad. PALABRAS CLAVE R E S U M E NAlteraciones en el eje intestino-riñón durante la enfermedad renal crónica: causas, consecuencias y propuestas de tratamiento

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Effects of a Symbiotic on Gut Microbiota in Mexican Patients With End-Stage Renal Disease

Cited by 65 publications

References 24 publications

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

The cross-talk between the kidney and the gut: implications for chronic kidney disease

Alteraciones en el eje intestino-riñón durante la enfermedad renal crónica: causas, consecuencias y propuestas de tratamiento

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