Effects of a nutraceutical combination of monacolin, γ-oryzanol and γ-aminobutyric acid on lipid profile and C-reactive protein in mice

Abstract

The aim of this study was to evaluate the efficacy of two nutraceutical agents aimed to improve lipid profile in a sample of mice. Material and methods: Fifty mice were randomly divided into four groups. Control mice were fed a standard diet (SD), while the other three groups were fed with a high-fat diet (HFD) for 4 weeks. At the end of the run-in period, mice fed with the SD continued to follow the SD, while mice fed with the HFD were divided into three groups: one continued with the HFD, one continued to follow the HFD + a blend of natural components derived from rice and fermented rice (monacolin K 3%, g-oryzanol, and g-aminobutyric acid) (S1), and the other one followed the HFD + one nutraceutical containing monacolin K 3% alone for 24 weeks. Results: The results showed that mice treated with HFD + S1 and HFD + S2 had lower levels of TC compared to mice fed with the HFD alone (p < 0.01, and p < 0.05, respectively). Moreover, mice treated with HFD + S1 had lower TC and LDL-C levels compared to mice fed with HFD + S2 (p < 0.05). Mice treated with HFD + S1 or S2 had lower Tg levels compared to mice fed with the HFD (p < 0.05). Conclusions: We can conclude that a combination of monacolin K 3%, g-oryzanol, and g-aminobutyric acid is more effective than monacolin K 3% alone in reducing the negative effects of a HFD in a sample of specific pathogen-free mice.

Combination of Anoectochilus roxburghii Polysaccharide and Exercise Ameliorates Diet-Induced Metabolic Disorders in Obese Mice

“…Inflammation has emerged as a critical factor in the main cause of T2DM complications as it may trigger the onset and progression of diabetes (31). As expected, the HFD-fed mice showed a 170.8% increasing serum CRP concentration, a liversecreted cytokine in modulating inflammatory responses (32,33). The HFD+ARP and HFD+ARP+EX groups could effectively attenuate CRP levels and exhibit a 16.7 and 23.8% decrease, but HFD+EX had no obvious effect on CRP (Figure 3A).…”

Hsa_circ_0054633 regulates PDGF-BB-induced proliferation, migration and oxidative stress of vascular smooth muscle cells through miR-107/TXNIP axis

“…In this study, western blot analysis indicated hsa_circ_0054633 downregulation also decreased PDGF-BB-mediated up-regulation of PCNA, cyclin D1 and MMP9 expression, further revealing the involvement of hsa_circ_0054633 in PDGF-BB-induced HA-VSMC dysfunction. ROS always is generated during the inflammatory response, which oxidizes low-density lipoproteins and results in structural damage and dysfunction of endothelial cells, ultimately leads to vascular remodeling [27][28][29]. Also, the antioxidant system, such as SOD2 enzyme, a mitochondrial enzyme that catalyzes the conversion of O2 •to hydrogen peroxide (H2O2), and the amount of ROS are kept in a certain state of homeostasis [30][31][32].…”