Effects of a Multispecies Probiotic Supplement on Bone Health in Osteopenic Postmenopausal Women: A Randomized, Double-blind, Controlled Trial

Jafarnejad, Sadegh; Djafarian, Kurosh; Fazeli, Mohammad Reza; Yekaninejad, Mir Saeed; Rostamian, Abdolrahman; Keshavarz, Seyed Ali

doi:10.1080/07315724.2017.1318724

Cited by 109 publications

(121 citation statements)

References 57 publications

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“…Recently, a short-term prospective double-blind study has been conducted in postmenopausal women [98]. In this study 50 women were treated with placebo or the multispecies probiotic supplement GeriLact for 6 months.…”

Section: Manipulation Of Microbiota Changes Bone Remodelingmentioning

confidence: 99%

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From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone

Hsu

Pacifici

2017

Calcif Tissue Int

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Osteomicrobiology refers to the role of microbiota in bone health and the mechanisms by which the microbiota regulates post-natal skeletal development, bone aging, and pathologic bone loss. Here, we review recent reports linking gut microbiota to changes in bone phenotype. A pro-inflammatory cytokine milieu drives bone resorption in conditions such as sex steroid hormone deficiency. The response of the immune system to activation by the microbiome results in increased circulating osteoclastogenic cytokines in a T cell-dependent mechanism. Additionally, gut microbiota affect bone homeostasis through nutrient absorption, mediation of the IGF-1 pathway, and short chain fatty acid and metabolic products. Manipulation of microbiota through prebiotics or probiotics reduces inflammatory cytokine production, leading to changes in bone density. One mechanism of probiotic action is through upregulating tight junction proteins, increasing the strength of the gut epithelial layer, and leading to less antigen presentation and less activation of intestinal immune cells. Thus, prebiotics or probiotics may represent a future therapeutic avenue for ameliorating the risk of postmenopausal bone loss in humans.

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Section: Manipulation Of Microbiota Changes Bone Remodelingmentioning

confidence: 99%

“…No changes in bone density were detected probably because of the short duration of the study. However, patients treated with probiotics had a reduction in indices of bone turnover, and serum levels of TNF and PTH [98]. …”

Section: Manipulation Of Microbiota Changes Bone Remodelingmentioning

confidence: 99%

From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone

Hsu

Pacifici

2017

Calcif Tissue Int

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“…In a similar study, 50 postmenopausal women with osteopenia (50–72 years of age) were randomly assigned to take either GeriLact (7 probiotic bacteria species) or a placebo for 6 months. The multispecies probiotic GeriLact significantly decreased biomarkers of bone resorption in comparison with the placebo group, though no significant changes in bone mineral density were observed during this period of treatment [66]. Interestingly, the probiotic treatment did significantly decreased serum levels of parathyroid hormone and the pro-inflammatory marker TNF-α [66].…”

Section: ) Probiotics and Bone Healthmentioning

confidence: 99%

“…The multispecies probiotic GeriLact significantly decreased biomarkers of bone resorption in comparison with the placebo group, though no significant changes in bone mineral density were observed during this period of treatment [66]. Interestingly, the probiotic treatment did significantly decreased serum levels of parathyroid hormone and the pro-inflammatory marker TNF-α [66]. Another study, that saw an effect on bone density, involved the treatment of osteoporotic males (64–67 years of age) with Kefir fermented milk for 6 months.…”

Section: ) Probiotics and Bone Healthmentioning

confidence: 99%

Probiotics in Gut-Bone Signaling

Schepper

Irwin

Kang

et al. 2017

Advances in Experimental Medicine and Biology

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The intestinal environment is linked to an array of conditions and diseases, including osteoporosis. Human and animal studies indicate that probiotics can benefit intestinal health and may provide a useful therapeutic to prevent and/or treat bone loss. Probiotics are defined as live microorganisms that when administered in adequate amounts will confer a health benefit on the host. In this review, we will focus on 1) probiotics (definition, history, nomenclature, types), 2) the effects of probiotics on bone health and 3) mechanisms of probiotic prevention of bone pathologies.

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“…The numbers of participants were similar and were divided randomly into the intervention group and the control group, among which seven studies were designed as double‐blind trials, and three studies were used cross‐control experiments. The studies met the inclusion were performed in six countries, including America (Holloway et al, ), Japan (Takimoto et al, ), Sweden (Nilsson, Sundh, Backhed, & Lorentzon, ), Taiwan (Tu et al, ), India (Gohel et al, ), and Iran (Asemi et al, ; Farhangi et al, ; Jafarnejad et al, ).…”

Section: Resultsmentioning

confidence: 99%

Effects of Probiotics, Prebiotics, and Synbiotics on Calcium Homeostasis and Bone Health With Aging: A Systematic Review

Liu

Zhao

Yang

et al. 2019

Worldviews Ev Based Nurs

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Background: Calcium homeostasis and bone health are an increasing concern for middleaged and older adults. Many studies have explored the positive effects of probiotics, prebiotics, or synbiotics on serum calcium and bone mineral density (BMD) or other parameters related to bone health. However, the participants, the species, doses and duration of interventions, outcomes, and measurements varied among these studies.Aims: To systematically evaluate the effect of probiotics, prebiotics, or synbiotics on maintaining calcium homeostasis and improving bone health in middle-aged and older adults. . Randomized controlled trials (RCTs) involving probiotics, prebiotics, or synbiotics for middle-aged or older adults were employed for meta-analysis by using RevMan 5.3, and heterogeneity and risk of bias assessment were performed.Results: A total of eight studies, involving 564 participants, were included. Probiotics, prebiotics, or synbiotics supplementation was able to significantly elevate serum calcium levels (0.52 mg/dl, 95% CI [0.38, 0.66]), heterogeneity: p = .13, I 2 = 44%), while the results of metaanalysis failed to support the effects of this supplementation on the parameters related to bone health in middle-aged and older adults, including BMD, parathyroid hormone, osteocalcin, and alkaline phosphatase.Linking Evidence to Action: Probiotics, prebiotics, or synbiotics supplementation exerts a facilitating influence on the level of serum calcium, while the present study has not yet supported the beneficial effects of such interventions on bone health. Therefore, further studies with high-quality RCTs are required to determine the effects of probiotics, prebiotics, or synbiotics supplementation on middle-aged and older adults.

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Effects of a Multispecies Probiotic Supplement on Bone Health in Osteopenic Postmenopausal Women: A Randomized, Double-blind, Controlled Trial

Abstract: These results may suggest the favorable effects of the multispecies probiotic supplementation for 6 months on bone health in postmenopausal women due to slowing down the rate of bone turnover.

Cited by 109 publications

References 57 publications

From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone

From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone

Probiotics in Gut-Bone Signaling

Effects of Probiotics, Prebiotics, and Synbiotics on Calcium Homeostasis and Bone Health With Aging: A Systematic Review

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