Effects of Probiotics, Prebiotics, and Synbiotics on Calcium Homeostasis and Bone Health With Aging: A Systematic Review

Liu, Yang; Zhao, Yajie; Yang, Yajun; Wang, Zhiwen

doi:10.1111/wvn.12405

Cited by 8 publications

(6 citation statements)

References 23 publications

(48 reference statements)

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“…In contrast, in a meta-analysis combining 5 trials using prebiotics, 2 trials using probiotics, and one trial using a synbiotic (prebiotic and probiotic combined), no significant benefit to bone was found. 217…”

Section: Dietary Bioactivesmentioning

confidence: 99%

Sorting Dietary Advice for Bone Health

Weaver,

Wallace,

Cao

2024

Nutr Today

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Healthcare professionals are consistently bombarded with conflicting messages about the role of diet in bone health. Yet, few resources are available that compile the broad scope of dietary factors that influence bone health. This article evaluates the evidence on the association of diet and exercise with bone health, with the aim to provide a resource for healthcare professionals and researchers in the field. This review also highlights gaps in knowledge, provides dialogue around why some studies exhibit conflicting outcomes, and showcases why many remaining questions likely cannot be answered with the current evidence to date. The best evidence to date supports obtaining recommended dairy and calcium intakes for building bone in early life and mitigating bone loss with age. However, nutrients do not solely work in isolation, and there is growing evidence that many other nutrients and dietary bioactives play a synergistic role in supporting bone health. Large randomized controlled trials, particularly in traditionally underserved subpopulations (eg, people of color, transgender individuals, older adults, etc), are needed to fully elucidate the effects of diet and exercise on bone health across the lifespan.

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Section: Dietary Bioactivesmentioning

confidence: 99%

Sorting Dietary Advice for Bone Health

Weaver,

Wallace,

Cao

2024

Nutr Today

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“…Nevertheless, human studies have yielded divergent results (Table 1). For example, a meta-analysis compiling data from RCTs involving 564 subjects states that even though the consumption of probiotics increases serum calcium levels, it does not improve markers of bone health [187]. In contrast, Jansson et al [188] conducted a randomised, double-blind, multicentre placebo study in Sweden involving 249 postmenopausal women for 12 months, where they found three Lactobacillus species prevented bone loss in the lumbar spine.…”

Section: Therapeutic Approach Against Ageing: Influencing the Gut Mic...mentioning

confidence: 99%

Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator

Salazar

Durán

Díaz

et al. 2023

IJERPH

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The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy.

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“…In humans, earlier research concluded that symbiotic bacteria restore the skin barrier; protect against photoaging; and improve hair quality [ 290 ], cognitive function, and aging-mediated memory impairment during aging [ 291 - 293 ]. Liu et al also argued that ingesting symbiotics significantly upregulated serum calcium concentrations in older individuals, although its benefits to bone health remained ambiguous [ 294 ].…”

Section: Emerging Approaches: Interventions In the Gut Microbiota In ...mentioning

confidence: 99%

Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

Shen¹,

He²,

Hou³

et al. 2022

Aging and disease

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Recently, there has been an increase in the incidence of malignant tumors among the older population. Moreover, there is an association between aging and cancer. During the process of senescence, the human body suffers from a series of imbalances, which have been shown to further accelerate aging, trigger tumorigenesis, and facilitate cancer progression. Therefore, exploring the junctions of aging and cancer and searching for novel methods to restore the junctions is of great importance to intervene against aging-related cancers. In this review, we have identified the underlying pathogenetic mechanisms of aging-related cancers by comparing alterations in the human body caused by aging and the factors that trigger cancers. We found that the common mechanisms of aging and cancer include cellular senescence, alterations in proteostasis, microbiota disorders (decreased probiotics and increased pernicious bacteria), persistent chronic inflammation, extensive immunosenescence, inordinate energy metabolism, altered material metabolism, endocrine disorders, altered genetic expression, and epigenetic modification. Furthermore, we have proposed that aging and cancer have common means of intervention, including novel uses of common medicine (metformin, resveratrol, and rapamycin), dietary restriction, and artificial microbiota intervention or selectively replenishing scarce metabolites. In addition, we have summarized the research progress of each intervention and revealed their bidirectional effects on cancer progression to compare their reliability and feasibility. Therefore, the study findings provide vital information for advanced research studies on age-related cancers. However, there is a need for further optimization of the described methods and more suitable methods for complicated clinical practices. In conclusion, targeting aging may have potential therapeutic effects on aging-related cancers.

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Effects of Probiotics, Prebiotics, and Synbiotics on Calcium Homeostasis and Bone Health With Aging: A Systematic Review

Cited by 8 publications

References 23 publications

Sorting Dietary Advice for Bone Health

Sorting Dietary Advice for Bone Health

Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator

Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

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