Effects of a long-term treatment with raloxifene on insulin sensitivity in postmenopausal women

Lasco, Antonino; Gaudio, Agostino; Morabito, Nunziata; Previti, M.; Mileto, A; Frisina, N; Cucinotta, Domenico

doi:10.1007/s00125-004-1328-4

Cited by 19 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to short-term treatment, long-term raloxifene treatment (12 months) did not modify fasting glucose or glucose tolerance [53]. However, in contrast to short-term treatment, long-term raloxifene treatment decreased insulin sensitivity [53]. This may need further investigation since the number of study subjects in this report was small (only 24 patients).…”

Section: The Effects Of Raloxifene On Metabolismmentioning

confidence: 70%

“…The impact of raloxifene on serum lipids profile has been explored in postmenopausal women in multiple clinical studies. Like estrogen, raloxifene significantly decreased LDL cholesterol level [50,51,53,55]. However, unlike estrogen, raloxifene did not change HDL cholesterol [50,51] or triglyceride levels [50,51,56] regardless of the duration of treatment.…”

Section: The Effects Of Raloxifene On Metabolismmentioning

confidence: 77%

“…Notably, in a subgroup of patients with hyperinsulinemia, raloxifene significantly reduced plasma insulin by improving fractional hepatic extraction of insulin and peripheral insulin sensitivity [49]. Similar to short-term treatment, long-term raloxifene treatment (12 months) did not modify fasting glucose or glucose tolerance [53]. However, in contrast to short-term treatment, long-term raloxifene treatment decreased insulin sensitivity [53].…”

Section: The Effects Of Raloxifene On Metabolismmentioning

confidence: 94%

See 2 more Smart Citations

Effect of selective estrogen receptor modulators on metabolic homeostasis

Lovre

Mauvais-Jarvis

2016

Biochimie

View full text Add to dashboard Cite

Section: The Effects Of Raloxifene On Metabolismmentioning

confidence: 70%

Section: The Effects Of Raloxifene On Metabolismmentioning

confidence: 77%

Section: The Effects Of Raloxifene On Metabolismmentioning

confidence: 94%

See 1 more Smart Citation

Effect of selective estrogen receptor modulators on metabolic homeostasis

Lovre

Mauvais-Jarvis

2016

Biochimie

View full text Add to dashboard Cite

“…Indeed, in human-cultured hepatocellular carcinoma (HepG2) cells, RLX showed no effect on intracellular TG accumulation. 15 Similarly in healthy postmenopausal women, RLX did not increase serum TG [16][17][18][19] or boost liver TG production in predisposed individuals. 19,20 Additionally, no argument exists for an effect of RLX in improving β-cell functions in postmenopausal women with T2D.…”

mentioning

confidence: 93%

Selective estrogen receptor modulation in pancreatic β-cells and the prevention of type 2 diabetes

Tiano

Mauvais-Jarvis

2012

Islets

View full text Add to dashboard Cite

“…In contrast to estrogen's effect in maintaining insulin sensitivity, short-term treatment with raloxifene decreases insulin sensitivity in healthy nondiabetic postmenopausal women [108]. Additionally, a 12-month raloxifene treatment was associated with reduced insulin sensitivity in women with postmenopausal osteoporosis, but without modification of plasma glucose concentration and tolerance [109].…”

Section: Estrogens Adipocytokines and Metabolic Syndromesmentioning

confidence: 96%

The role of estrogen in adipose tissue metabolism: insights into glucose homeostasis regulation [Review]

2014

View full text Add to dashboard Cite

Abstract. Adipose tissue is an organ with active endocrine function involved in the regulation of energy balance and glucose homeostasis via multiple metabolic signaling pathways targeting the brain, liver, skeletal muscle, pancreas, and other organs. There is increasing evidence demonstrating that the female sex hormone, estrogen, regulates adipose development and improves systemic glucose homeostasis in both males and females. The underlying mechanism linking estrogenic regulation in adipose tissue and systemic glucose metabolism has not been fully elucidated, but is thought to include interactions of estrogen receptor signaling events involving lipolytic and/or lipogenic enzyme activity, free fatty acid metabolism, and adipocytokine production. Thus, understanding the effects of estrogen replacement on adipose tissue biology and metabolism is important in determining the risk of developing obesity-related metabolic disorders in patients undergoing treatment for sex hormone deficiency. In this report, we review literature regarding the role of estrogens and their corresponding receptors in the control of adipose metabolism and glucose homeostasis in both rodents and humans. We also discuss the effects of selective estrogen receptor modulators on glucose metabolism. Key words: Estrogen, Adipose tissue, Glucose homeostasis, Estrogen receptors, Selective estrogen receptor modulatorsIT HAS BEEN WELL established that adipose tissue is a dynamic tissue which is involved in the regulation of glucose and lipid metabolism, energy homeostasis and inflammation. In addition, adipose tissue is a complex and highly active endocrine organ that is a major site of sex steroid metabolism and production of bioactive adipokines that act at both the local (autocrine/ paracrine) and systemic (endocrine) level [1]. Thus, a functional failure of adipose tissue can cause changes in systemic energy delivery, impair glucose consumption, and affect the activation of self-regulatory mechanisms that regulate the whole body homeostasis system [2]. In addition, assessing the regional distribution of adipose tissue is critical during clinical examination of patients, particularly if they are obese [3]. The multiple endocrine abnormalities found in abdominal visceral obesity are more pronounced than in other obesity phenotypes [3].At menopause, women begin to develop increased amounts of visceral fat with redistribution of body fat. The risk of developing obesity-related diseases is significantly lower in premenopausal women than that in men, but not anymore after menopause, indicating the significant role of the female estrogen hormone in adipogenesis and adipose metabolism [4]. Furthermore, since adipose tissue serves as a crucial integrator of glucose homeostasis, estrogen deficiency strongly contributes to impaired glucose metabolism and the development of type 2 diabetes accompanied by abnormal adipose function. In fact, visceral adiposity is associated with postmenopausal women and ovariectomized (OVX) rodents, a condition that can be re...

show abstract

Effects of a long-term treatment with raloxifene on insulin sensitivity in postmenopausal women

Abstract: A long-term treatment with raloxifene in osteoporotic, otherwise healthy post-menopausal women can reduce insulin sensitivity without affecting glucose tolerance.

Cited by 19 publications

References 12 publications

Effect of selective estrogen receptor modulators on metabolic homeostasis

Effect of selective estrogen receptor modulators on metabolic homeostasis

Selective estrogen receptor modulation in pancreatic β-cells and the prevention of type 2 diabetes

The role of estrogen in adipose tissue metabolism: insights into glucose homeostasis regulation [Review]

Contact Info

Product

Resources

About