Effect of selective estrogen receptor modulators on metabolic homeostasis

Xu, Beibei; Lovre, Dragana; Mauvais-Jarvis, Franck

doi:10.1016/j.biochi.2015.06.018

Cited by 36 publications

(21 citation statements)

References 78 publications

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“…For instance, continuous stimulation of the mammary gland by E2 is associated with the development and progression of breast cancer (13). Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily of transcription factors that act as key mediators of estrogen activity (14,15). Moreover, ERα has previously been demonstrated to regulate cell proliferation, differentiation and homeostasis in numerous tissues, and play a critical role in determining a prognosis or therapeutic strategy for breast cancer (16).…”

Section: Introductionmentioning

confidence: 99%

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Lin

Wang

Gao

et al. 2017

Experimental and Therapeutic Medicine

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Section: Introductionmentioning

confidence: 99%

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Lin

Wang

Gao

et al. 2017

Experimental and Therapeutic Medicine

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“…Diminished bone formation by osteoblasts or excessive bone resorption by osteoclasts results in osteoporosis (4). In postmenopausal women, osteoporosis is induced by a decrease in the production of estrogen, which is known to maintain the appropriate ratio of osteoblasts to osteoclasts (5,6). To treat postmenopausal osteoporosis, the most widely prescribed medications are bisphosphonates such as alendronate and zolendronic acid, although their longterm administration may increase the incidence of osteonecrosis of the jawbone and fracture of the femur (7,8).…”

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confidence: 99%

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model

Liu

et al. 2019

FASEB j.

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Osteoporosis is a major health problem, making bones fragile and susceptible to fracture. Previous works showed that mechanical loading stimulated bone formation and accelerated fracture healing. Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess effects of mechanical loading to the spine, using ovariectomized (OVX) mice as a model of osteoporosis. Two‐week daily application of this novel loading (4N, 10Hz, 5 min/d) altered bone remodeling with an increase in Wnt3a. Spinal loading promoted osteoblast differentiation, endothelial progenitor cell migration, and tube formation and inhibited osteoclast formation, migration, and adhesion. A transient silencing of Wnt3a altered the observed loading effects. Spinal loading significantly increased bone mineral density, bone mineral content, and bone area per tissue area. The loaded OVX group showed a significant increase in the number of osteoblasts and reduction in osteoclast surface/bone surface. Though expression of osteoblastic genes was increased, the levels of osteoclastic genes were decreased by loading. Spinal loading elevated a microvascular volume as well as VEGF expression. Collectively, this study supports the notion that Wnt3a‐mediated signaling involves in the effect of spinal loading on stimulating bone formation, inhibiting bone resorption, and promoting angiogenesis in OVX mice. It also suggests that Wnt3a might be a potential therapeutic target for osteoporosis treatment. —Li, X., Liu, D., Li, J., Yang, S., Xu, J., Yokota, H., Zhang, P. Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model. FASEB J. 33, 8913–8924 (2019). http://www.fasebj.org

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“…After menopause, women's estrogen levels decreased significantly, estrogen through the estrogen receptor (ER) directly effect on the osteoblast and osteoclasts, lead to imbalance of bone resorption and bone formation, resulting in reduced bone mass and BMD, increased bone fragility and the occurrence of osteoporosis (31,32). The decrease of estrogen level and the decrease of the expression of ER in bone tissue are one of the most important pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Mongolian Medicine echinops prevented postmenopausal osteoporosis and induced ER/AKT/ERK pathway in BMSCs

Liu

Wang

Chang

et al. 2018

BST

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Hormone replacement medicine such as traditional Chinese medicine has proven to be effective in decreasing the risk of osteoporosis. Mongolian medicine echinops prevents osteoporosis, but its mechanism remains unclear. In this study, we explored the mechanism underlying echinops prevents and treats postmenopausal osteoporosis. Osteoporosis model was established by ovariectomy in rats. Rats were treated to Echinops (16.26, 32.5, or 65 mg/kg/day) by oral gavage for 3 months. Bone mineral density (BMD) was detected by micro-CT detection of left proximal medial metaphyseal tibia. Hematoxylin and eosin (H&E) and toluidine blue O staining were also performed. Serum levels of E2, ALP and testosterone were examined. Bone marrow-derived bone marrow stem cells (BMSCs) were isolated and treated with echinops-containing serum. Estrogen receptors (ER) including ERα and ERβ in bone specimens and BMSCs were detected by qRT-PCR. Cell viability and colon formation of BMSCs were detected. Expressions of ERα, ERβ, AKT, p-AKT, ERK, and p-ERK in BMSCs were detected by western blot. Results showed that echinops significantly increased trabecular interconnectivity, thickness of trabeculae, and connection of trabecula. Echinops significantly increased BMD and E2, but significantly reduced ALP and testosterone in dose-dependent manners. Echinops induced ERα and ERβ in both bone specimens and BMSCs. Echinops enhanced cell viability and ability of colony formation of BMSCs, and increased ERα, ERβ, p-AKT, and p-ERK. Thus, Mongolian echinops reduced bone loss and delayed the occurrence and development of osteoporosis, and increased ERα, ERβ, p-AKT, and P-ERK in BMSCs. These results provide experimental basis for clinical prevention and treatment of postmenopausal osteoporosis by echniops.

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Effect of selective estrogen receptor modulators on metabolic homeostasis

Cited by 36 publications

References 78 publications

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model

Mongolian Medicine echinops prevented postmenopausal osteoporosis and induced ER/AKT/ERK pathway in BMSCs

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