MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Lin, Jun; Wang, Li; Gao, Jie; Zhu, Shuchai

doi:10.3892/etm.2017.4828

Cited by 14 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To more directly interrogate the relationship between collagen architecture, stromal stiffness, and epithelial density, as well as to rule out potentially confounding effects of age, parity, behavior of human breast cancer cells, were repressed both in the MCF10A MECs cultured on the stiff PA gels and as 3D preassembled acini embedded within a ribose-stiffened BM/collagen gel ( Figure 5, E-H). We focused on miR-203 for further analysis because of its prior role in restricting breast cancer progression and its implicated role in breast cancer risk (38,(50)(51)(52)(53)(54). Consistently, miR-203 expression levels significantly decreased in the freshly isolated primary murine mammary organoids embedded within the ribose-stiffened BM/collagen gels ( Figure 5I).…”

Section: Resultsmentioning

confidence: 74%

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Northey¹,

Barrett²,

Acerbi³

et al. 2020

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 74%

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Northey¹,

Barrett²,

Acerbi³

et al. 2020

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Two of the previous studies reported miR-203 as an oncogene, as silence of its expression inhibited breast cancer cells colony formation, transformation, stemness and migration [21,37]. Others suggested miR-203 as an anti-oncogene through performing in vitro experiments [22,38,39]. This contradiction may due to the different cell lines used and the difference in testing parameters.…”

Section: Discussionmentioning

confidence: 99%

Luteolin exhibits anti-breast cancer property through up-regulating miR-203

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Luteolin is a representative of natural flavonoid that has anti-tumour properties. This study designed to check its impact on breast cancer and the underlying mechanisms. MDA-MB-453 and MCF-7 cells were administrated with luteolin and the following techniques were carried out: CCK-8 assay, FITC-PI doublestaining and Western blot. qRT-PCR analysis was utilized to see the effects of luteolin on miR-203 expression. Besides, miR-203 expression was silenced by transfection with specific inhibitor. Luteolin remarkably declined MDA-MB-453 and MCF-7 cells viability and accelerated apoptosis which accompanied by Bax up-regulation, Bcl-2 down-regulation and Caspase-3 cleavage. Also, luteolin impeded TGFb1-induced EMT, as evidenced by the decreased levels of Vimentin, Zeb1 and N-cadherin, as well as the increased level of E-cadherin. miR-203 was highly expressed in 22 pair of breast cancer tissues than the matched paracancerous tissues. Luteolin could elevate miR-203 level. Besides, luteolin's antitumour effects were partially eliminated by miR-203 silence. Further, luteolin inhibited Ras/Raf/MEK/ERK signalling, while the inhibitory effects were flattened by miR-203 silence. Luteolin significantly reduced breast cancer cells growth and EMT. Luteolin exerted its anti-tumour effects possibly involved the elevated expression of miR-203 and the inhibited Ras/Raf/MEK/ERK signalling.

show abstract

“…On the other hand, decreased levels of miR-497 participate in the cell proliferation, migration, and invasion of ER-negative breast cancer by targeting ERα [67]. Conversely, miR-203 suppresses the estrogen-induced viability, migration and invasion of ERα-positive breast cancer cells [68]. miR-107-5p has a direct interaction with ESR1 to enhance the proliferation and invasion of endometrial carcinomas [69].…”

Section: Mirnas and Er Function In Cancersmentioning

confidence: 99%

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Taheri

Shoorei

Dinger

et al. 2020

Cancers

View full text Add to dashboard Cite

Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with different tissue-specific functions. ERα and ERβ are two nuclear members of this family, whereas G protein-coupled estrogen receptor (GPER), ER-X, and Gq-coupled membrane estrogen receptor (Gq-mER) are membrane-bound G protein-coupled proteins. ERα participates in the development and function of several body organs such as the reproductive system, brain, heart and musculoskeletal systems. ERβ has a highly tissue-specific expression pattern, particularly in the female reproductive system, and exerts tumor-suppressive roles in some tissues. Recent studies have revealed functional links between both nuclear and membrane-bound ERs and non-coding RNAs. Several oncogenic lncRNAs and miRNAs have been shown to exert their effects through the modulation of the expression of ERs. Moreover, treatment with estradiol has been shown to alter the malignant behavior of cancer cells through functional axes composed of non-coding RNAs and ERs. The interaction between ERs and non-coding RNAs has functional relevance in several human pathologies associated with estrogen regulation, such as cancers, intervertebral disc degeneration, coronary heart disease and diabetes. In the current review, we summarize scientific literature on the role of miRNAs and lncRNAs on ER-associated signaling and related disorders.

show abstract

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Abstract: Abstract. Breast cancer is common in females, and accounts for a large proportion of cancer-related cases of mortality.

Cited by 14 publications

References 37 publications

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Luteolin exhibits anti-breast cancer property through up-regulating miR-203

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Contact Info

Product

Resources

About