Effects of a 12-week healthy-life exercise program on oxidized low-density lipoprotein cholesterol and carotid intima-media thickness in obese elderly women

Park, Jong‐Hwan; Park, Hyuntae; Lim, Seung-Taek; jinkee, Park

doi:10.1589/jpts.27.1435

Cited by 16 publications

(13 citation statements)

References 22 publications

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“…CIMT was measured using B-mode ultrasound and a 10-MHz probe (LOGIQ 3, GE Healthcare, Wauwatosa, WI, USA). During measurement of the carotid arteries, the subjects lay on their backs in a dark room, turned their heads 45 degrees, and fully exposed the carotid arteries after they relaxed for minimum 10 minutes; left carotid artery was then measured by ultrasound 21 , 22 ) . Three IMT measurements of diastolic images on each side at 10 mm before or after the carotid bifurcation were obtained.…”

Section: Methodsmentioning

confidence: 99%

The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults

2015

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[Purpose] The aim of this study was to examine the relationships between the amount and distribution of body fat and the carotid intima-media thickness to explore whether coronary artery disease risk may be mediated through effects on the amount of fat mass in older adults. [Subjects and Methods] A total of 200 elderly females was participated. The percentage of body fat mass was measured by the bioelectrical impedance analysis method, and the carotid intima-media thickness was measured by B-mode ultrasound. Analysis of covariance was performed to assess independent associations between the four categories of percentage of body fat mass and the carotid intima-media thickness after multivariate adjustment. Logistic regression analyses were utilized to calculate odds ratios and 95% confidence intervals for examining independent associations between percentage of body fat mass and the estimated risk of coronary artery disease. [Results] Analysis of covariance showed that the carotid intima-media thickness was significantly thick in both obesity and overweight groups. When multivariate-adjusted OR for the estimated risk of coronary artery disease, the odds ratios for the obesity and overweight groups were 3.0 (95% confidence interval, 1.1 to 8.7) and 2.5 (95% confidence interval, 1.0 to 6.1), respectively. [Conclusion] This study demonstrates that elderly females with a high body fat mass are more likely to have the estimated risk of CAD than who fit body fat mass in elderly female.

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Section: Methodsmentioning

confidence: 99%

The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults

2015

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“…A 12-week healthy-life exercise program was reported to reduce circulating ox-LDL levels and carotid IMT in obese elderly women. 44 Tavridou et al 45 reported that treatment with simvastatin 40 mg/d for 12 weeks significantly reduced circulating ox-LDL levels by 6.5% ± 5.2% and 31.1% ± 5.0% in hypercholesterolemia subjects with and without CHD, respectively. Likewise, a study by Aydin et al 46 showed that both rosuvastatin 20 mg/d and atorvastatin 80 mg/d had comparable effects on circulating ox-LDL levels.…”

Section: Effect Of Medical Therapy and Lifestyle Modifications On Ox-mentioning

confidence: 99%

Association between circulating oxidized low‐density lipoprotein and atherosclerotic cardiovascular disease

Gao

Liu

2017

Chronic Diseases and Translational Medicine

103

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Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuring ox-LDL in the circulation, effect of medical therapy and life-style modification on ox-LDL level, and the association between circulating ox-LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.

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“…Studies in adults have shown reductions in plasma markers of oxidative stress after weight loss induced by a lifestyle intervention [22,23]. A few studies have evaluated the effect of weight loss programs on ox-LDL lipoproteins [15,24,25], anti ox-LDL and PON1 [26] in obese pediatric populations.…”

Section: Discussionmentioning

confidence: 99%

Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1 are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese Children During Weight-Loss Therapy

Gajewska¹,

Chełchowska²,

Ambroszkiewicz³

et al. 2018

Exp Clin Endocrinol Diabetes

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Background Oxidative stress and impaired production of adipokines in childhood obesity contribute to the development of obesity-related disorders. We assessed whether weight loss after lifestyle intervention alters biomarkers of oxidant/antioxidant status, and whether these alterations are associated with changes in anthropometric parameters and adipokines in obese children. Materials and Methods We determined oxidized low-density lipoprotein (ox-LDL), anti ox-LDL, paraoxonase1 (PON1), leptin, soluble leptin receptor (sOB-R), total adiponectin, high molecular weight adiponectin concentrations and body composition (by dual-energy X-ray absorptiometry) in 60 prepubertal obese children (Body Mass Index, BMI Z-score>2) before and after a 3-month intervention. The control group consisted of 44 non-obese children (BMI Z-score<−1+1>). Results Ox-LDL, ox-LDL/LDL, and anti ox-LDL concentrations as well as leptin to sOb-R ratio were reduced (p<0.001; p=0.018; p<0.001; p<0.001, respectively) in obese children with weight loss (BMI Z-score change≤−0.5) after a 3-month therapy. These parameters were stable in the obese group without weight loss (BMI Z-score change>−0.5). Changes in ox-LDL and PON1 levels in all obese children correlated positively with changes in the leptin to sOB-R ratio (r=0.400, p=0.002; r=0.304, p=0.028, respectively). After adjustment for changes in BMI Z-score in the multivariate regression model, the association between the changes in ox-LDL levels and changes in the leptin/sOb-R ratio remained statistically significant (β=0.184, p=0.014). Conclusions We found out that a 3-month lifestyle intervention associated with weight loss improves the oxidant/antioxidant balance and promotes anti-atherogenic changes in prepubertal obese children in a way dependent on the alterations in the leptin to sOB-R ratio.

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Effects of a 12-week healthy-life exercise program on oxidized low-density lipoprotein cholesterol and carotid intima-media thickness in obese elderly women

Cited by 16 publications

References 22 publications

The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults

The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults

Association between circulating oxidized low‐density lipoprotein and atherosclerotic cardiovascular disease

Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1 are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese Children During Weight-Loss Therapy

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