The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults

Abstract

[Purpose] The aim of this study was to examine the relationships between the amount and distribution of body fat and the carotid intima-media thickness to explore whether coronary artery disease risk may be mediated through effects on the amount of fat mass in older adults. [Subjects and Methods] A total of 200 elderly females was participated. The percentage of body fat mass was measured by the bioelectrical impedance analysis method, and the carotid intima-media thickness was measured by B-mode ultrasound. Analysis of covariance was performed to assess independent associations between the four categories of percentage of body fat mass and the carotid intima-media thickness after multivariate adjustment. Logistic regression analyses were utilized to calculate odds ratios and 95% confidence intervals for examining independent associations between percentage of body fat mass and the estimated risk of coronary artery disease. [Results] Analysis of covariance showed that the carotid intima-media thickness was significantly thick in both obesity and overweight groups. When multivariate-adjusted OR for the estimated risk of coronary artery disease, the odds ratios for the obesity and overweight groups were 3.0 (95% confidence interval, 1.1 to 8.7) and 2.5 (95% confidence interval, 1.0 to 6.1), respectively. [Conclusion] This study demonstrates that elderly females with a high body fat mass are more likely to have the estimated risk of CAD than who fit body fat mass in elderly female.

Adiposity Phenotypes and Subclinical Atherosclerosis in Adults from Sub–Saharan Africa: An H3Africa AWI–Gen Study

“…Our finding that various adiposity phenotypes were associated with greater CIMT in both women and men expands the evidence on this matter since it has been previously reported in European, American, African–American and Asian populations [ 17 18 19 37 38 ]. In our study, BMI showed a stronger association with CIMT compared to the other measures of adiposity.…”

“…Extensive research has shown that common CIMT, assessed using B-mode ultrasonography, is a marker of the presence of atherosclerosis locally and elsewhere in the arterial system, and, as such, is an intermediate stage for the development of CVDs [ 14 15 16 ]. However, most of the research examining the relationship of adiposity with atherosclerosis, assessed using common CIMT has been conducted in Whites [ 17 ], Asians [ 18 19 20 ] and African–Americans [ 21 ] from high income countries, but little information is available for black African populations from SSA.…”

Association between Obesity and Carotid Intima-Media Thickness in Korean Office Workers: The Mediating Effect of Physical Activity

“…CIMT correlates with BMI and WC/WHtR in children and adolescents [ 22 ], in middle-aged adults [ 23 ], and in older adults [ 24 ]. In a sample of Korean older women, Park et al [ 25 ] also showed overweight and obese women had significantly higher risks of subclinical atherosclerosis (OR=3.033, 95%CI=1.064-8.650 and OR=2.459, 95%CI= 0.998-6.059, respectively) after adjustments for age, height, systolic blood pressure, physical activity level, and total cholesterol level, as compared with optimal weight women. In addition, central obesity was found to be more closely associated with an abnormally increased CIMT in middle-aged and elderly Chinese [ 24 ].…”

Association of Frailty Syndrome and Sarcopenia With Subclinical Atherosclerosis in Older Patients

“…showed that there was no association of overall obesity or visceral obesity with the presence of carotid plaque [20,21]. Research by Kim Tae Nyun et al showed the ratio of muscle to fat to be associated with arterial stiffness [22].…”