2018
DOI: 10.1055/a-0723-3951
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Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1 are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese Children During Weight-Loss Therapy

Abstract: Background Oxidative stress and impaired production of adipokines in childhood obesity contribute to the development of obesity-related disorders. We assessed whether weight loss after lifestyle intervention alters biomarkers of oxidant/antioxidant status, and whether these alterations are associated with changes in anthropometric parameters and adipokines in obese children. Materials and Methods We determined oxidized low-density lipoprotein (ox-LDL), anti ox-LDL, paraoxonase1 (PON1), leptin, soluble leptin r… Show more

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“…Previous studies involving small groups of patients did not find any significant differences in PON1 concentrations between obese and non-obese subjects [34,35]. However, in this study, we identified a substantial increase in the serum concentration of this protein in morbidly obese patients.…”
Section: Discussioncontrasting
confidence: 77%
“…Previous studies involving small groups of patients did not find any significant differences in PON1 concentrations between obese and non-obese subjects [34,35]. However, in this study, we identified a substantial increase in the serum concentration of this protein in morbidly obese patients.…”
Section: Discussioncontrasting
confidence: 77%