Effects of 940 nm light-emitting diode (led) on sciatic nerve regeneration in rats

Abstract

The objective of the present study was to evaluate the effect of 940 nm wavelength light emitting diode (LED) phototherapy on nerve regeneration in rats. Forty male Wistar rats weighing approximately 300 g each were divided into four groups: control (C); control submitted to LED phototherapy (CLed); Sciatic Nerve Lesion without LED phototherapy (L); Sciatic Nerve Lesion with LED phototherapy (LLed). The lesion was caused by crushing the right sciatic nerve. A dose of 4 J/cm(2) was used for ten consecutive days beginning on the first postoperative day. Groups C and L were submitted to the same procedure as the LLed group, but the equipment was turned off. The LED phototherapy with 940 nm wavelength reduced the areas of edema, the number of mononuclear cells present in the inflammatory infiltration, and increased functional recovery scores at 7, 14 and 21 days. The results suggest that the use of phototherapy at 940 nm after nerve damage improves morphofunctional recovery and nerve regeneration.

Light‐emitting diode therapy induces analgesia and decreases spinal cord and sciatic nerve tumour necrosis factor‐α levels after sciatic nerve crush in mice

“…LEDT's lack of regenerative effects presented herein differs from literature results, in which LEDT (940 nm, 4 J/cm 2 ) has been proven to stimulate the repair process of the calcaneal tendon in rats (640 nm, 20 J/ cm 2 ) (Bastos et al, 2009;Casalechi et al, 2009), as well as the morphofunctional recovery after SNC in rats (940 nm, 9.5 mW, 4 J/cm 2 ) (Serafim et al, 2012). The apparent contradictory results are probably due to the differences in doses, i.e., 20 and 4 J/cm 2 , which are more intense than the 2.5 J/cm 2 used in our study.…”

“…Conversely, LEDT analgesic effect has not been investigated in pre-clinical models of pain. Nevertheless, LEDT presented anti-inflammatory activity and has reduced the expression of TNF-a in a rabbit osteoarthritis model (Oshima et al, 2011), decreased the levels of TNF-a and IL-1b mRNA at the site of calcaneal tendinitis in rats (Xavier et al, 2010a); inhibited the expression of cyclooxygenase-2 and prostaglandin E2 and pro-inflammatory cytokines in vitro (Lim et al, 2007;Choi et al, 2012); as well as stimulated morphofunctional recovery after SNC in rats (Serafim et al, 2012). Moreover, Costa et al (2008) demonstrated that LEDT when applied to acupuncture points was effective -at varying degrees -in the treatment of 15 patient with chronic pain.…”

Memória Oral Do Contestado Entre Espírito Santo E Minas Gerais: Um Olhar Sobre a Participação De Barra De São Francisco E Mantena

“…Dentre as terapias atualmente em destaque, temos a fototerapia com LED (light-emitting diodediodo emissor de luz). Estudos tem descrito que a LEDterapia está associada com aceleração no processo de cicatrização de feridas na pele, melhora na recuperação de lesão por isquemia no coração e até atenuação na degeneração do nervo óptico lesionado (SERAFIM et al, 2012;HEMMINGS et al, 2017). Atribuem-se parte dos efeitos do LED à estimulação na função mitocondrial, neste contexto, estudos in vitro e in vivo, sugeriram que o LED é capaz de estimular as funções mitocondriais por aumentar o consumo de oxigênio, a produção de ATP, o transporte de elétrons e por promover redução na formação de espécies reativas do oxigênio e ainda minimizar reações inflamatórias, possivelmente por interferir na geração/ação da citocina TNFα.…”

LED session prior incremental step test enhance VO2max in running

“…The application of light, by sources of low-level laser or lightemitting diode (LED), has been widely studied in health sciences and potentially aids the prevention and recovery of injuries, as well as anti-inflammatory and analgesic effects, although the influence on human exercise, as well as sportrelated context, as injuries, soreness, training recovery, rehabilitation, and performance enhancement, should be better explored [1][2][3]. Moreover, little theoretical bases were found to support LED as ergogenic aid for oxidative phosphorylation metabolism response.…”