Effects of 17 α-methyltestosterone on transcriptome, gonadal histology and sex steroid hormones in rare minnow Gobiocypris rarus

Gao, Jiancao; Liu, Shaozhen; Zhang, Yingying; Yang, Yanping; Yuan, Cong; Chen, Shu; Wang, Zaizhao

doi:10.1016/j.cbd.2015.05.001

Cited by 18 publications

(24 citation statements)

References 84 publications

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“…In contrast, the exposure of Danio rerio fish to this progestagen causes irreversible endocrine changes and leads to a change in gene expression (Liang et al 2015;Sangster et al 2016). The presence of testosterone in the aqueous environment reduces the concentration of vitellogenin in Gobiocypris rarus females, while in males of the same species, a significant decrease in sperm count compared to the control group was observed (Gao et al 2015). Not only fish but also amphibians and reptiles are sensitive to testosterone in the aquatic environment.…”

Section: Introductionmentioning

confidence: 89%

Inhibition of growth of Anabaena variabilis population by single and mixed steroid hormones

et al. 2018

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Many contaminants which are toxic and adversely affect living organisms enter surface waters. Among them, there are endocrine compounds such as steroid hormones, which can disrupt the endocrine system causing an adverse effect on the physiology of aquatic organisms. In the literature, there is not enough information about the influence of steroid hormones on phytoplankton growth. Therefore, the aim of this research was to study the effect of estrogens (estrone, 17ß-estadiol, 17-α-ethinylestradiol, and estriol), progestagens (progesterone, 5-pregnen-3b-ol-20-one, and levonorgestrel), and androgens (testosterone) on the growth of the cyanobacterium Anabaena variabilis. To our best knowledge, the chronic toxicological effects of hormones on cyanobacteria are explored for the first time. ), while estrone, estriol, and levonorgestrel showed no significant effect on the growth of this cyanobacterium. Hormone mixtures have been found to be more toxic than single substances and exposure to them leads to the potentiation of toxicity. The EC 50 after 14 days of the test duration for the mixed steroid hormones were 45.14, 37.00, and 89.46 mg L −1. This research provides a basic understanding of hormone toxicity to aquatic organism, such as cyanobacteria, and asserts a more comprehensive view on ecological risk evaluation.

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Section: Introductionmentioning

confidence: 89%

Inhibition of growth of Anabaena variabilis population by single and mixed steroid hormones

et al. 2018

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“…Zebrafish are a well-known animal model in toxicology studies, but they are less sensitive than rare minnows to some contaminants, such as cadmium (Cd), mercury (Hg), copper (Cu) and zinc (Zn) . In addition, gonad transcriptome data for rare minnow have recently become available (Gao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure

Wang

Liu

Jin

et al. 2016

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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“…This approach assesses coordinated, large-scale transcriptional responses rather than focusing on targeted candidate genes (e.g., via qPCR). RNA-seq approaches have been used to investigate the role of androgens on gene expression, particularly in the context of sex differences (Gao et al, 2015; Cox et al, 2017) and gonadal development (Monson et al, 2017; Zheng et al, 2019). Similarly, RNA-seq based studies have been crucial in providing a more comprehensive understanding of the complex and dynamic immune and stress responses (e.g., Barshis et al, 2013; Huang et al, 2013; Kim et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Developing a transcriptomic framework for testing testosterone-mediated handicap hypotheses

Newhouse

Vernasco

2019

Preprint

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13Sexually selected traits are hypothesized to be honest signals of individual quality due to the 14 costs associated with their development or expression. Testosterone, a sex steroid known to 15 influence the production of sexually selected traits, has been proposed to underlie the costs 16 associated with sexually selected traits via its immunosuppressive effects (i.e., the 17 Immunocompetence Handicap Hypothesis) or by influencing an individual's 18 exposure/susceptibility to oxidative stress (i.e., the Oxidation Handicap Hypothesis). Previous 19 work testing these hypotheses has primarily focused on physiological measurements of immunity 20 or oxidative stress, but little is known about the molecular pathways by which testosterone could 21 influence immunity and/or oxidative stress pathways. To measure the molecular consequences of 22 experimentally elevated testosterone, we used previously published RNA-seq data from studies 23 that measured the transcriptome of individuals treated with either a testosterone-filled or an 24 empty (i.e., control) implant. Two studies encompassing two species of bird and three tissue 25 types fit our selection criteria. We found strong support for the Immunocompetence Handicap 26 Hypothesis, but no support for the Oxidation Handicap Hypothesis. More specifically, 27 testosterone-treated individuals exhibited strong signatures of immunosuppression, 28 encompassing both cell-mediated and humoral immunity. Our results suggest that testosterone 29 enforces the honesty of sexually-selected traits by influencing an individual's 30 immunocompetence rather than their exposure or susceptibility to oxidative stress.31 32

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Effects of 17 α-methyltestosterone on transcriptome, gonadal histology and sex steroid hormones in rare minnow Gobiocypris rarus

Cited by 18 publications

References 84 publications

Inhibition of growth of Anabaena variabilis population by single and mixed steroid hormones

Inhibition of growth of Anabaena variabilis population by single and mixed steroid hormones

Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure

Developing a transcriptomic framework for testing testosterone-mediated handicap hypotheses

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