Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial

Blom, Wendy A M; Abrahamse, S.L.; Bradford, Roberta; Duchateau, Guus; Theis, Winfried; Orsi, Antonia; Ward, Caroline L; Mela, David J.

doi:10.3945/ajcn.111.020321

Cited by 52 publications

(25 citation statements)

References 19 publications

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“…Worse, to date most of the agents proposed or currently sold as "functional" food ingredients for appetite control appear to lack consistent support for efficacy, or are unsuitable or ineffective in desired food formats (Wiseman et al, 2008;Keogh et al, 2010;Appleton et al, 2011;Smit et al, 2011;Blom et al, 2011;Peters et al, 2009Peters et al, , 2011aVerhoef and Westerterp, 2011;Chan et al, 2012;Márquez et al, 2012). The market potential for such (proprietary) solutions makes them highly attractive, but the costs and time needed for developing ingredients that are truly novel (in terms of source, chemistry, or biological target) and which can be brought to market with regulatory approval and substantiated claims, are barriers to commercial investment and feasibility.…”

Section: Current Status Of "Functional" Approaches To Satietymentioning

confidence: 99%

Applying Structuring Approaches for Satiety

Mela

Boland

2014

Food Structures, Digestion and Health

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Section: Current Status Of "Functional" Approaches To Satietymentioning

confidence: 99%

Applying Structuring Approaches for Satiety

Mela

Boland

2014

Food Structures, Digestion and Health

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“…And after 15 days' consumption infuse of Kemuning leaves, measuring again BMI, waist circumference and pelvis circumference of respondents. To minimize refraction review because of influence from the intake of the different respondent's meals every day and not homogeneous physical activity, So respondents also requested to fill food recall and physical Activity questionnaire 10,11 To make simplicia Kemuning leaves, the process is, (1) Take Kemuning leaves, (2) Separation of Kemuning leaves that have a fresh green color, (3) Washed from dirty until clean, (4) Drained and weighed, (5) Dried in the drying cupboard into simplicia, (6) Simplicia be mashed into simplicia powder, (7) Followed by weighing the powder simplicia be 15 gram (8) Heating water 480 ml of aquadest to boil, (9) Put in 1 sachet of simplicia powder, (10) Let it boil and water is 240 ml, (11) Filtered using filter paper, (12) kemuning leaves infusion is poured into a glass 240 ml. Make sure simplicia is dry and fully submerged.…”

Section: Methodsmentioning

confidence: 99%

Effect of Consumption Kemunings Leaf (Murraya Paniculata (L.) Jack) Infuse to Reduce Body Mass Index, Waist Circumference and Pelvis Circumference on Obese Patients

Sukohar¹,

Busman²,

Kurniawaty³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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Obesity has reached epidemic proportions the world, with more than 1 billion adults are overweight and 300 million of them in clinically is obese that a major contributor to the burden of chronic disease and disability globally. Determining the classification of obesity can be determined by measuring the body mass index (BMI), waist circumference or pelvis circumference. Consumption of herbal drugs have excess minimal side effects than chemical drugs. Examples of herbs used for weight loss is kemuning leaves (Murraya paniculata (L.) Jack) infuse. The study was to determine differences in BMI, pelvic circumference, waist circumference and pelvic waist circumference ratio (waist pelvis ratio) before and after administration of kemuning leaves infuse in obese patients. The method is quasi experimental with by one group before and after design. Population in this study was all obesity employees in University of Lampung. There were 17 sample taken from population with consecutive sampling technique. The result showed the mean BMI was 30.33±4.61 kg/m2 and 29.67±4.29 kg / m2, pelvic circumference 110.41±10.65 cm and 109.24±9.36 cm, waist circumference 94.65±10.04 cm and 96.06±9.90 cm, and waist pelvis ratio of 1.17±0.07 and 1.14±0.06 before and after administration of kemuning leaves infuse for 15 days. There are differences between the mean BMI and waist pelvis ratio before and after giving kemuning leaves infuse (p=0.006) and (p=0.037), there are no differences between the mean pelvis circumference and waist circumference before and after giving kemuning leaves infuse (p=0.194) and (p=0.278) in obese patients at the University of Lampung.

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“…18 Side effects, including transient increased bilirubin and elevated liver enzymes, and mild to moderate shortterm adverse events (AE), including headache and gastric upset, have been reported. 19,20 The scope of this consumer trial was limited to a 40-day study period with minimal intervention. The objective was to assess the efficacy and tolerability of 40 days of repeated consumption of the test product in adult individuals.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Acceptance of a CommercialHoodia parvifloraProduct for Support of Appetite and Weight Control in a Consumer Trial

Landor

Benami

Segev³

et al. 2015

Journal of Medicinal Food

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Species of Hoodia Sweet ex Decne., family Apocynaceae, a southern African succulent plant, have been recognized for their appetite suppressing properties. Products that support appetite and weight control have been developed in Israel from locally cultivated Hoodia spp. To study consumer acceptance, efficacy of, and tolerance for a frozen product based on whole aerial parts of Hoodia parviflora N.E. Br., we initiated and conducted this single-blind, randomized, placebo-controlled consumer trial. Volunteer participants ingested flavored 3 g frozen Hoodia or placebo cubes for 40 days. Subjects were weighed and measured and baseline body-mass index was determined. Adverse events were monitored and eight mild, transient, possible treatment-emergent events were reported. No moderate, severe, or chronic events were reported. On days 1, 10, and 40, subjects self-reported their perceptions of food consumption, hunger development, incidence and control of food cravings, and efficacy of the product. On day 40, the treatment group demonstrated a statistically significant decrease in measured quantitative parameters against the placebo and reported a positive perception of the product.

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Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial

Cited by 52 publications

References 19 publications

Applying Structuring Approaches for Satiety

Applying Structuring Approaches for Satiety

Effect of Consumption Kemunings Leaf (Murraya Paniculata (L.) Jack) Infuse to Reduce Body Mass Index, Waist Circumference and Pelvis Circumference on Obese Patients

Efficacy and Acceptance of a CommercialHoodia parvifloraProduct for Support of Appetite and Weight Control in a Consumer Trial

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