Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults

Abstract

Purpose: To investigate the effects of topically applied 1% cyclopentolate hydrochloride on anterior segment parameters obtained with a Pentacam rotating Scheimpflug camera in healthy young adults. Methods: Anterior segment analyses of 25 eyes from 25 young adults (Group 1), before and after 45 min of 1% cyclopentolate hydrochloride application, were performed. For a control group (cycloplegia-free, Group 2), 24 eyes of 24 age-and sex-matched healthy cases were evaluated twice at 45 min intervals. The results obtained from the groups were compared statistically. Results: The mean ages of the groups were 23.04 ± 3.42 (range, 18-29) and 22.4 ± 2.05 (range, 18-27) years for Groups 1 and 2, respectively (p=0.259). In Group 1, measurements between the two analyses were significantly different for the values of anterior chamber depth (ACD), anterior chamber angle (ACA), and anterior chamber volume (ACV) (p<0.05), whereas no statistical difference was found for the central corneal thickness (CCT) and keratometry (K1, K2) measurements. In Group 2, none of these parameters were statistically different between the two analyses. Conclusions: Topically applied 1% cyclopentolate hydrochloride caused an increase in the ACD and ACV values, and a decrease in the ACA value. However, it had no significant effect on the CCT and keratometry measurements. It is important to consider these effects when using the Pentacam device on young adults with cycloplegia and when applying it for various reasons.

Comparison of cyclopentolate versus tropicamide on corneal topography in emmetropic and myopic eyes

“…Consistent with our results, a previous study on the cycloplegic effect of cyclopentolate 1% and tropicamide 1% in adults' refractive outcomes also revealed no signi cant differences between cycloplegic effects of these two drops [14]. The in uence of cycloplegic eye drops on corneal curvature was also assessed in previous studies [15][16][17][18][19][20][21]. The assessment of tropicamide in uence on corneal topography in adults showed no signi cant changes in corneal radius, power and astigmatism after administration [15].…”

“…The assessment of tropicamide in uence on corneal topography in adults showed no signi cant changes in corneal radius, power and astigmatism after administration [15]. Also, investigation of cyclopentolate eye drop administration on corneal parameters using pentacam showed that cyclopentolate has no signi cant effect on keratometry measurements [16]. Evaluation of biometric parameters following cycloplegia using Lenstar and IOLMaster biometers also revealed no signi cant differences in axial length and corneal curvature measurements with and without cycloplegia with both devices [17].…”

Comparative Study of the Effects of 1% Atropine on the Anterior Segment

“…In previous similar studies, other ciliary muscle paralysis drugs have generally been used instead of atropine, and in adults, the anterior chamber angle tends to be shallower with cycloplegia. Arici et al [ 27 ] have shown that the use of 1% cyclopentolate in young adults, as measured by Pentacam, resulted in an anterior chamber angle decrease from 38.09° ± 8.13° to 33.95° ± 10.14°. Similar results have been obtained with the use of 1% tropicamide by Palamar et al [ 28 ].…”

Anizohipermetropik ambliyopisi olan yetişkinlerin ön segment parametrelerinin Sirius topografi ile değerlendirilmesi

“…Topical administration of cyclopentolate hydrochloride 1% is commonly used, especially in pediatric ophthalmologic examinations, to obtain transitory cycloplegia and mydriasis. Earlier studies evaluated the effects of cyclopentolate hydrochloride 1% on anterior segment in children and young adults using the Pentacam (18,19). In study by Arıcı et al (18), the cycloplegic effect of 1% cyclopentolate increased ACD and ACV, and decreased anterior chamber angle (ACA) values in anterior segment parameters, due to the backward movement and decreased thickness of the crystalline lens.…”

“…Earlier studies evaluated the effects of cyclopentolate hydrochloride 1% on anterior segment in children and young adults using the Pentacam (18,19). In study by Arıcı et al (18), the cycloplegic effect of 1% cyclopentolate increased ACD and ACV, and decreased anterior chamber angle (ACA) values in anterior segment parameters, due to the backward movement and decreased thickness of the crystalline lens. Palamar et al (19) found that cyclopentolate hydrochloride 1% instillation causes statistically significant increase in ACD and ACV and decrease in CCT, compared with precycloplegia measurements.…”