Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice

Sun, Huilin; Chen, Na; Yang, Xiaona; Xia, Yankai; Wu, Di

doi:10.1016/j.ecoenv.2021.112340

Cited by 102 publications

(40 citation statements)

References 61 publications

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“…A dosage of 150 mg kg −1 day −1 of C3G was used by us, and the exposure time was based on previous studies. 23,25,26…”

Section: Resultsmentioning

confidence: 99%

“…Besides oxidative stress, the immune response also plays a pivotal role in cellular homeostasis, and MPs exposure could impact the immune response, thereby resulting in inflammation. 26 Over-production of ROS stimulates the release of pro-inflammatory cytokines. 31 Consequently, the levels of key inflammatory factors TNF-α, IL-1β and CD45 in colon or liver tissues were quantified by IHC analysis (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

et al. 2022

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“…A dosage of 150 mg kg −1 day −1 of C3G was used by us, and the exposure time was based on previous studies. 23,25,26…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

et al. 2022

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“…A total of 23 studies were excluded because of carried out using a mixture of contaminants including MPs and lack of statistical data analysis. Finally, 19 studies (6 in vitro, 11 in vivo and 2 both in vivo and in vitro) were included in this review [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45].…”

Section: Resultsmentioning

confidence: 99%

“…The general/methodological information of the included in vitro and/or in vivo studies are described in Table 1 (Ref. [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]). In particular, 11 studies (5 in vitro studies [29,33,37,38,42], 4 in vivo [27,30,32,36] and 2 both [34,39]) investigated exposure to PS , 3 studies investigated PP exposure (2 in vitro [37,41,42] and 1 in vivo [41]), 3 studies investigated PE exposure (1 in vitro [42] and 2 in vivo [28,31]), 2 studies investigated exposure to MPs (2 in vivo studies [44,45]) instead of PVC exposure (1 study in seen [3]), polymers (1 in vitro study [43]), LDPE (1 in vivo study [35]), HDPE (1 in vivo study [40]), SFb and LFb (1 in vivo study [41]), sphere (1 in vivo study [45]) and NPs (1 in vivo study…”

Section: Resultsmentioning

confidence: 99%

Effects of Nano and Microplastics on the Inflammatory Process: In Vitro and In Vivo Studies Systematic Review

Pulvirenti¹,

Ferrante²,

Barbera³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Microplastics (MPs) and Nanoplastics (NPs) are plastic fragments that spread in the environment and accumulate in the human body, so they have been becoming a worldwide environmental concern because of their potential human health effects. The aim of this systematic review was to investigate the prospective impact of MPs and NPs on the inflammatory process. Methods: Electronic article search was performed on PubMed, Scopus and Web of Science international databases from 1 Jan 2012 to 31 Dec 2021. Screenings of titles, abstracts and full texts were performed according to the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA). The methodological quality of the studies was checked by the Toxicological data Reliability Assessment Tool. Results: Electronic article search identified 125 records, from which 6 in vitro, 11 in vivo and 2 both in vivo and in vitro studies were included. Both in vivo and in vitro studies have showed an increase ofdifferent inflammatory outcomes (Interleukines, Tumor necrosis factor, Chemokines, Interferones, Transcription factors, Growth factors, Oxydoreductase, Proteins and others), thus it seems to confirm the association withthe exposure to microplastics of different types, sizes, exposure times and exposed species. Conclusions: This systematic review seems to support the relationship between the exposure to MPs and the inflammatory processboth in vivo and in vitro. Greater caution is needed about the role of NPs because ofa very small number of studies. Additional high-quality studies are warranted to confirm these results, especially the research should be focused on NPs being lacking literature.

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“…Neutrophil activation, epithelial detachment, mucous hyper secretion, and immune responses were noted after MPs exposure in zebrafish ( Limonta et al, 2019 ). Immune activation and gut microbiota dysbiosis following ingestion have also been revealed in fish ( Li et al, 2021a ) and mouse ( Sun et al, 2021 ), indicating potential immune activation and toxicity in vertebrate. Human exposure to MPs can also result in the activation of immune defensive responses.…”

Section: Introductionmentioning

confidence: 99%

Impacts of microplastics on immunity

et al. 2022

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Most disposable plastic products are degraded slowly in the natural environment and continually turned to microplastics (MPs) and nanoplastics (NPs), posing additional environmental hazards. The toxicological assessment of MPs for marine organisms and mammals has been reported. Thus, there is an urgent need to be aware of the harm of MPs to the human immune system and more studies about immunological assessments. This review focuses on how MPs are produced and how they may interact with the environment and our body, particularly their immune responses and immunotoxicity. MPs can be taken up by cells, thus disrupting the intracellular signaling pathways, altering the immune homeostasis and finally causing damage to tissues and organs. The generation of reactive oxygen species is the mainly toxicological mechanisms after MP exposure, which may further induce the production of danger-associated molecular patterns (DAMPs) and associate with the processes of toll-like receptors (TLRs) disruption, cytokine production, and inflammatory responses in immune cells. MPs effectively interact with cell membranes or intracellular proteins to form a protein-corona, and combine with external pollutants, chemicals, and pathogens to induce greater toxicity and strong adverse effects. A comprehensive research on the immunotoxicity effects and mechanisms of MPs, including various chemical compositions, shapes, sizes, combined exposure and concentrations, is worth to be studied. Therefore, it is urgently needed to further elucidate the immunological hazards and risks of humans that exposed to MPs.

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Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice

Cited by 102 publications

References 61 publications

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

Effects of Nano and Microplastics on the Inflammatory Process: In Vitro and In Vivo Studies Systematic Review

Impacts of microplastics on immunity

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