Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

Abstract

Microplastics (MPs) ingested and accumulated by organisms would ultimately pose a threat to humans via food chain. A balanced gut microbiota contributes to many health benefits, which is readily...

The gut microbiota, a key to understanding the health implications of micro(nano)plastics and their biodegradation

“…Lu et al (2018) and Jin et al (2019) found a relative reduction in the abundance of Proteobacteria in ICR mice after treatment with 0.5, 5, and 50 μm PS MNPs at concentrations of 100 and 1000 μg/L. The same results were obtained from another mouse model (C57BL/6) and different dose of MPs (0.1 mg/day) by Chen, Zhu, et al (2022). In contrast, Jiang, Yuan, et al (2021) and Qiao et al (2021) found an elevation in relative abundance of Proteobacteria in C57BL/6 mice after PS MP ingestion, which is consistent with the findings of Liu, Lv, et al (2022).…”

Protective role of bayberry extract: associations with gut microbiota modulation and key metabolites

“…To observe the impact of C3G treatment on the fat drops in C57BL/6 or db/db mice, 20 we embedded liver and colon tissues from each group of mice in paraffin, cutting them into 4 μm thick and staining with HE. Then the accumulation of fat drops in the liver and colon tissues was observed by using a CKX41 microscope (Olympus, Japan).…”

Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats

“…to improve enteritis in mice. 59 Meanwhile, some bacteria, such as Flavonifractor plautii, Slackia equolifaciens, Slackia isoflavoniconvertens, Adlercreutzia equolifaciens, Eubacterium ramulus, Eggerthella lenta and Bifidobacterium spp., are involved in the metabolism of anthocyanins, cyanidin, peonidin, pelargonidin, malvidin, suggesting that the bidirectional interaction between anthocyanins and gut microbes may contribute to host health. [60][61][62] Considering that different anthocyanins and other phenolic compounds in the crude extract may have different effects on T2DM development, we believe that the bioavailability, bioac-tivity, and molecular conformation of different anthocyanins in the crude extract in relation to the interaction with the gut microbiota and serum metabolome still need further study.…”